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Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应,采用HPLC和LC-MS/MS法测定对应的7种代谢产物(1,7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑)的浓度,通过与对照组比较,确定MPD对以上7种酶活性的影响。

The protonation constants of formylformic acid thiosemicarbazone (A, H2FFTSC) and glycylglycine and stability constants of binary complexes formed they with Mn, Co, Ni, Cu and Zn and trinary complexes of M-FFTSC-GG at 25±0.1℃ and in the presence of 0.1 mol.L-1 KNO3 were determined. The relation between the stability of binary complexes of M-FFTSC and their disinfectivity and disinfection mechanism were discussed.

在25±0.1℃,I=0.1 mol.L-1 KNO3条件下,应用pH法测定了甲酰基甲酸缩氨基硫(A配体,缩写H2FFTSC),甘氨酰甘氨酸的质子化常数,它们与锰、钴、镍、铜和锌的二元配合物以及过渡金属-甲酰基甲酸缩氨基硫-甘氨酰甘氨酸三元配合物稳定常数,讨论了过渡金属席夫碱配合物的杀菌活性与其稳定性之间的关系,对杀菌机理提出了一些看法。

METHODS: Ureaplasma urealyticum detection was performed in 16 samples of the umbilic blood of the malformed fetuses, sperms of the father, and cervical mucus of the mother who conceived the malformed fetus.

对16例畸形胎儿脐带血,畸形儿父亲的精液和异常妊娠产妇的宫颈黏液或阴道分泌物进行解原体分离。

In the end, the effects of methylation on the properties of uracil and adenine-uracil base pair have been investigated.

最后,我们研究了甲基化对嘧啶单体以及腺嘌呤-嘧啶碱基对的影响情况。

The activity of Urase and Sucrase in different degradation stages showed significant variance (P.05); the activity of Urase in different soil layers were significant P.

草甸退化使土壤酶和蔗糖酶活性出现了显著变化(P.05),酶活性在不同土层间差异显著(P.05),蔗糖酶没有表现出土体层次性差异;相关分析表明,高寒草甸的土壤酶活性与营养成分含量之间相关不显著。

The Simpson and Shannon-Weiner indices of aquatic plant diversity were both significantly positively correlated with catalase, protease and invertase, and negatively correlated with urase, soil organic matter and total nitrogen. Similarly, soil organic matter and total nitrogen were negatively correlated with catalase, protease and invertase but positively correlated with urase.

植物α多样性指数(辛普森、香浓-维纳指数)与湿地土壤有机质、全氮含量呈负相关,与土壤过氧化氢酶、蛋白酶、蔗糖酶活性呈正相关,与酶活性呈负相关;土壤有机质、全氮含量与过氧化氢酶、蛋白酶、蔗糖酶活性呈一致负相关,与酶活性则成正相关。

Immobilization of urease can solve the problem, it have a good stability, and furthermore it can use repeatedly.

固定化可以提高酶的稳定性,并可以重复使用,可以很好的克服游离酶的缺点。

The results showed that there was a distinctly different effect on urease activity by the three different herbicides.

酶在尿素转化过程中起关键作用,当尿素施人土壤后,在酶的催化作用下,迅速分解成COz和NH。。

A series of nitrogen fixation characteristics, such as nodule nitrogen fixation activity, nodule ureide content and young stem ureide content were studied in the same latitude and differently evolutionary types of soybean.

本试验研究了中国同一纬度不同进化类型大豆主要生育时期的根瘤固氮酶活性、根瘤酰含量和幼茎段酰含量。

Objective To determine association of U. urealyticum and its two biovars with nongonococcal urethritis.

目的 阐明溶原体及其2个生物群与非淋菌性尿道炎的关系。

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化,但却比去年同期高8%。

However, to get a true quote, you will need to provide detailed personal and financial information.

然而,要让一个真正的引用,你需要提供详细的个人和财务信息。