脒

Three ways leads to the synthesis of fenclorin, one way discussed here has 3 steps. Stepl :benzonitrile using as raw material goes though dry hydrogen chloride and becomes a-imino phenylmethyl ether after meet carbinol.

解草啶的合成主要有三条路线，本文选取合成路线是以苯甲腈为原料，经三步反应而成：1、苯甲腈在干燥的氯化氢通入，与甲醇形成亚氨基苯甲醚，通入氨气后置换甲氧基得到苯基脒盐酸盐(收率76.18%)。2、苯基脒盐酸盐在碱性条件下与丙二酸二乙酯环合而得嘧啶醇(收率84.39%)。3、嘧啶醇在三氯氧磷中羟基被氯化得到产品解草啶(收率87.29%)。

A process for reducing nitryl with unstable guanyl on para-position of benzene ring into azyl features that active metal reacts on organic acid and solvent at ordinary temp. and pressure to reduce N-(2 or 3-M, 5 or 6-M',4-nitrophenyl)-N',N'-dimethyl acetamidine into N-(2 or 3-m, 5 or 6-M', 4-aminophenyl)-N',N'-dimethyl acetamidine, where M=H,-R,-OR,-COOR (R=H, C1-C6); and M'=H,-R,-OR,-COOR (R=H, C1-C6). Its advantages include reduced by-reaction and high reducting rate up to 80%-95%.

本发明是将苯环上对位带有不稳定脒基的硝基还原为氨基的方法，采用活泼金属，如：锌或锡，与有机酸和适当的溶剂，在常温、常压下发生反应，将N－（2或3－M，5或6－M＇，4－硝基苯基）－N＇，N＇－二甲基乙脒还原为N－（2或3－M，5或6－M＇，4－氨基苯基）－N＇，N＇－二甲基乙脒，其中M＝H，－R，－OR，－COOR（R＝H，C1－C6），M＇＝H，－R，－OR，－COOR（R＝H，C1－C6），减少了副反应，使还原收率达到80％以上，最高可达95％以上，更适用于工业化生产。

The efficacy of aromatic diamidines in the treatment of protozoal diseases was first recognized in the 1930s by investigators searching for agents with therapeutic activity against African trypanosomiasis .

早在1930年，人们在寻找治疗非洲锥形虫症药物时首先发现了芳香二脒类化合物具有治疗原虫疾病的作用，临床试验表明戊烷脒及其类似物对非洲人早期锥形虫症和黑热病具有疗效。

The annulus amidine application in activator and solidify agent respect and get together a few application of amidine.

环脒在催化剂和固化剂方面的应用及聚脒的一些应用。

Add up to content to synthesize a lot of inadequacy in the method in view of amidine apperception, introduced a few kinds of new methods that synthesize amidine, enlarged the limits of raw material, raised yield.

鉴于脒类化合物合成方法中的诸多不足，介绍了几种新的合成脒的方法，扩大了原料的范围，提高了产率。

These studies indicate the rationality of our molecular design based on the crystal structure of KARI complex. To obtain more KARI inhibitors with high activities, the molecular docking and 3D-QSAR methods were applied to our further studying of these amidine compounds. Two methods AutoDock3. 0.3 and DOCK4. 0 were used in molecular docking, and the calculate results accord with that of herbicidal tests in general. The CoMFA model from 3D-QSAR analysis provided useful guidance for designing highly active compounds prior to their synthesis.

这些分子作为潜在的KARI抑制剂为基于KARI的农药分子设计提供了有利指导；对部分小分子进行了合成，在除草活性初筛的近三十个化合物中，个别化合物表现出较好的除草活性，其中一个化合物wb1596对油菜和稗草具有较高的生长抑制率，并通过E.coli KARI酶活性抑制试验验证了其KARI酶的作用靶标，此化合物可以作为KARI一个有苗头的抑制剂为后续工作奠定了基础；对发现的有苗头的KARI抑制剂进行了结构修饰和优化，合成了一系列脒类化合物并确证了它们的结构，改造后的化合物与原抑制剂相比大多除草活性相当或更佳，从而表明我们基于靶标结构的分子设计的合理可靠性；对所合成一系列脒类化合物进行了分子对接和三维定量构效关系研究。

The 9 common used insecticides of cypermethrin 4.5%EC, omethoate 40%EC, chlorpyrifos 40%EC, acetamiprid 3%EC, imidacloprid 10%EC provided excellent control for wheat aphids in fields. The control effects were over 90% at 7 days after spraying. The 9 insecticides had bad effects on aphidius and coccinellidae in three days after spraying and the number of two natural enemies decreased rapidly. But on the 7th day, the number of the two natural enemies increased and there were difference between those treated with imidacloprid, acetamiprid and abamectin and CK. BT had no evident difference compared to the control.

为了明确杀蚜药剂对麦蚜的防治效果、适宜的防治时期、对生态环境安全性和粮食作物食品安全性的影响，对4.5%氯氰菊酯、40%氧化乐果、40%毒死蜱、3%啶虫脒、10%吡虫啉等9种防治麦蚜的药剂进行了筛选，发现各药剂对麦蚜的防效较好，喷药后7d防效均在90%以上。9种农药在喷施后的3d内，对麦蚜的主要天敌蚜茧蜂和瓢虫影响较大，两种天敌数量锐减，但到7d时各处理蚜茧蜂数量均有回升，其中不同剂型的吡虫啉、啶虫脒和鲁植顺克处理的蚜茧蜂数量同对照相差不大。

The degradation kinetics of acetamiprid,including 20% water soluble powder and 3% emulsifiable concentrate,in cotton and soil was studied under field conditions.

应用GC-ECD测定，采用田间试验方法研究了20%啶虫脒可溶性粉剂和3%啶虫脒乳油在棉花和土壤中的残留消解动态，并对其在棉花上使用的安全性提出了建议。

The oxidant 〓 plays indirect role in dissolving gold, and mainly controls the mix potential of Au in the alkaline thiourea solution. In which the "mix potential"is the decisive factor affecting the dissolution of gold. The reaction driving force is enough to have formamidine disulfide oxidize Au to Au〓 at the potential of about 0.4V. And then thiourea molecular complexes with Au〓 ion soon, which causes the fast dissolution of gold in the alkaline thiourea media. The dissolved weight of gold in 0.25 M thiourea solution with 0.05M Na〓SO〓 and 0.1M 〓 of pH 12. 5 by air at the temperature of 303K is 7. 8mg·cm〓 within 1hr.

在碱性硫脲溶金过程不起直接作用，而是通过S〓O〓来控制二硫甲脒有效形成的金在溶液中的混合电位；&混合电位&是影响碱性硫脲溶液溶金与否的决定性因素，在0.4V左右，有足够的推动力致使二硫甲脒氧化Au成Au〓，随后硫脲与Au〓络合形成稳定的络离子Au〓，从而使金快速溶解；温度为303K、pH为12.5时，在含0.05MNa〓SO〓、0.1M 〓及0.25M硫脲的溶液中，鼓入空气，金的溶解量在1hr内为7.8mg·cm〓；铜只有微量溶解，银、镍、铁则几乎不溶解。

The optimum process starting from 1,3-dihydroxyacetone and formamidine acetate was: 22.54g(0.25mol) 1,3-dihydroxyacetone, 29.12g(0.28mol) formamidine acetate and 120ml isopropanol in liquid ammonia was heated to 40℃ for 8h.

以1，3-二羟基丙酮和醋酸甲脒为原料的较佳工艺：1，3-二羟基丙酮22.54g (0.25mol)，醋酸甲脒29.12g (0.28mol)，异丙醇120ml，通入液氨，40℃反应8h，减压蒸馏除去反应液中的氨气后过滤，滤液加至热的苦味酸饱和溶液，自然冷却至室温，制得4(5)-羟甲基咪唑苦味酸盐69.5g，收率85.0%。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。