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The top of neural tube forms basic encenphalic shape,namely endbrain, interbrain, midbrain and afterbrain. The abnormal closure of neural tube will result in neural tube detects. Encephalocoele is a common congenital malformation whose mechanism was no known. NO participates in the physiologic process of brain.

胚胎脑发育的早期阶段主要是神经板隆起、弯曲、闭合形成神经管,神经管的头部从前向后依次发育形成脑的基本组织形态,即端脑、间脑、中脑、后脑,在神经管闭合过程中出现异常就会导致NTD。

In adult brain, Xvax2 was expressed in ventral region of telencephalon and diencephalon, which contains olfactory bulb, hippocampus, optic chiasma, optic tract and hypothalamus.

Xvax2在成体脑中的分布仍局限于端脑和间脑腹侧,其表达区域主要包括嗅球、端脑侧脑室腹侧的海马区域,以及视交叉、视束初始段和下丘脑边缘。

We discovered that the mechanisms of borneol opening BBB involved (1) promoting the tight junction of endothelial cells opening:(2) increasing the quantity of pinocytosis vesicle in endothelial cells and enhance the pinocytosis;(3) inhibiting the activation of P-glycoprotein (P-glycoprotein is an efflux pump of drugs) and increase the permeability of BBB;(4) reducing the expression of intercellular adhesion molecule-1 in brain microvessel endothelial cells;(5) increasing the concentration of Ca〓 in brain microvessel endothelial cells;(6) increasing the activation of eNOS in brain microvessel endothelial cells.

随后,在对冰片开放血脑屏障的机制作进一步的研究时又发现,冰片开放血脑屏障的机制包括以下几个方面:(1)冰片可使血脑屏障内皮细胞间的紧密连接开放;(2)冰片能使内皮细胞内的囊泡数量增加,吞饮功能增强;(3)冰片能抑制P-糖蛋白的活性(P-糖蛋白是一种药物外排泵),而使血脑屏障的通透性增加;(4)冰片能使脑微血管内皮细胞ICAM-1表达量减少;(5)冰片使脑微血管内皮细胞内的Ca〓浓度升高;(6)冰片可升高脑微血管内皮细胞eNOS的活性。

When located posteriorly at the MDJ, lesions tended to continue downward along the pontine tegmentum and superior cerebellar peduncle, whereas the corticospinal tract was the structure affected in more anteriorly located lesions.

当病灶位于中脑-间脑结合处的偏后方时,倾向于沿着脑桥背盖部和小脑上脚向下延伸;当病灶向下延伸时,红核常不受累。

When located posteriorly at the MDJ, lesions tendedto continue downward along the pontine tegmentum and superiorcerebellar peduncle, whereas the corticospinal tract was thestructure affected in more anteriorly located lesions.

当病灶位于中脑-间脑结合处的偏后方时,倾向于沿着脑桥背盖部和小脑上脚向下延伸;当病灶向下延伸时,红核常不受累。

Specifically when operating Go/No go tasks,the brain blood flow in the areas of anterior cingulated cortex,the medial prefrontal,lateral inferior frontal gyrus and corpus callosum rise dramatically,which implies that deficiency may exist in the functions of these parts of the brain,and depressed patients among college students have the problem of behavioral inhibition in the cognitive aspect, which is connected with certain parts of the brain mechanism.

更多数图谱数据分析方法,发现抑郁症组和正常组间存在相应脑区局部脑血流的显著变化,具体体现在执行Go/No go任务时,前扣带回和前额内侧、额下回外侧和胼胝体区域内的脑血流显著升高,提示这些部位的脑功能可能存在功能性改变,说明抑郁症大学生在认知方面存在行为抑制,而且该问题与特定部位的脑机制有关。

One view, that episodic memory and semantic memory are both dependent on the integrity of medial temporal lobe and midline diencephalic structures, predicts that amnesic patients with medial temporal lobe/diencephalic damage should be proportionately impaired in both episodic and semantic memory.

一种观点认为,情节记忆和语义记忆都依赖颞叶内部和间脑中线结构,预言颞叶内部、间脑损伤的健忘症病人的情节和语义记忆会相应比例地被削弱。

One view, that episodic memory and semantic memory are both dependent on the integrity of medial temporal lobe and midline diencephalic structures, predicts that amnesic patients with medial temporal lobe/diencephalic damage should be proportionately impaired in both episodic and semantic memory.

一种观点认为,情节记忆和语义记忆都依赖颞叶内部和间脑中线结构,预言颞叶内部、间脑损伤的失忆症病人的情节和语义记忆会相应比例地被削弱。

Objective To study the protective action of compound agent madeup with effective ingredients of Hirudo and Rhizoma chuanxiong and Folium Ginkgo in animal ischemic cerebral infarction.Methods To mix Hirudin extracts of Folium Ginkgo and Ligustrazine according2:25:5into asepsis injection,rats local cereˉbral ischemia induced by embolism of middle cerebral arterywas used as experimental model to study the efˉfects of the compound agent and positive control drug,Nimodipine and extracts of Folium Ginkgo on cerebral infarct size and neurological deficits.Disposing the experimental data with statisticsand comparing their otherness among difˉferent groups.

目的 探讨用中药水蛭、银杏、川芎的有效成分组成的复方制剂对动物局灶脑缺血的保护作用方法将水蛭素、银杏叶提取物、川芎嗪按2∶25∶5的比例制成无菌注射液,应用鼠大脑中动脉栓塞导致缺血性脑卒中的实验模型,并用生理盐水、尼莫地平和银杏提取物作对照,观察不同药物对脑缺血面积和由缺血造成的大鼠行为障碍的影响,将实验据用统计学处理并进行组间的差异性比较。

MR images show a mild degree of cerebral atrophy, as slight widening of the hemispheric sulci, prominent in the parietal and perisylvian regions.

磁共振影像显示轻度脑萎缩,表现为两半球间脑沟的轻度增宽,顶部和大脑周边区域突出。

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