脑衰竭

Cause of death : 12 died of brain and meninges extensive metastases and 3 died of general cachexia.

照射者中位生存期6个月，未照射者为2个月。12例死于脑和脑膜、脊膜广泛转移，3例由于全身病变广泛伴全身衰竭而死亡。

Results 32 cases are success of the cardiopulmonary resuscitation.

结果心肺复苏成功32例，心肺脑复苏成功15例，复苏后发生多脏器功能衰竭28例。

The script of diagnostic criteria for MODS with the illness severity score system was established. The script mainly was involved in the evaluation of seven organs or systems, including respiratory system, cardiovascular system, kidney, hemologic system, liver and alimentary system. Only one parameter was used in each organ, they were FiO2/PaO2, systolic blood pressure, serum creatinine, platelet count, conscious state and the defecation status. 0- 4 scores were endued with each indexaccording to the severity of the illnesses respectively. Every descriptor was 5 points, showing 0 point with normal organ function, and 1- 4 scores with organ dysfunction and aggravation.

建立了MODS诊断标准、病情严重度评分系统草案：主要纳入呼吸、心血管、肾脏、凝血、脑、肝脏、胃肠道7个脏器系统，每个脏器系统仅用1个指标表示其功能障碍与否，分别是氧合指数、收缩压、血清肌酐浓度、血小板计数、意识状态、血清总胆红素浓度、排便状况；每个指标结合病情严重程度分别赋予0~4分，0分为功能正常，4分为器官功能衰竭，1~4分为器官功能发生障碍且程度逐渐加重。

Objective To evaluate the effects of high frequency oscillatory ventilation in the hypoxicischemic encephalopathy with respiratory failure.

目的 探讨高频振荡通气在新生儿严重缺氧缺血性脑病并呼吸衰竭的临床应用。

Results Nine cases were not exactly diagnosed and got proper treatment before admission in the total 12 cases,accounting for 75 perc...

结果12例患者中，有9例(75.0%)入院前未得到明确诊断和正确处理。12例(100.0%)均有伤口局部出血不止，全身多处大片皮下出血瘀斑；10例(83.3%)出现血尿、牙龈渗血症状；1例(8.35%)继发脑出血；2例(16.67%)出现出血性休克，其中1例并发急性肾功能衰竭：1例(8.35%)出现严重肺出血。

Objective:To observe the effects of Naloxone and Nikethamide on chronic respiratory failure with pulmonary encephalopathy.

目的 ：观察常规治疗的同时加用纳络酮(Naloxone，NLX)治疗慢性Ⅱ型呼吸衰竭肺性脑病的疗效。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

In their practice,they attached importance to nurse s mastery of respirator s function,management of respiratory tract,correct methods and right time for sput um drainage as well as the intensive care of cardiovascular and renal functions.

笔者介绍30例重症胰腺炎合并多器官功能衰竭患者的监护要点。在神经内科常规护理的基础上，对 36例重症脑卒中患者中的 14例施行监护，另 2 2例作为对照。

Due to the extent of the lesion, the existing ischemic brain damage and involvement of the torcular, no therapeutic options were available and the child died of irreversible cardiac failure.

由于该畸形导致的缺血性脑损伤的存在及中空区的累及，没有哪一种治疗方法是有效的，患者多死于不可逆性心脏功能衰竭。

The concents of two neurotransmitters don't have linear correlation with SCr, that is higher level of SCr doesn't mean lower brain DA and 5-HT concent.

急性肾功能衰竭并发脑病时，并非血肌酐值越高，脑组织中多巴胺、5-羟色胺浓度越低，二者无线性相关性。

I can not make it blossom and suits me

我不能让树为我开花

When temperatures are above approximately 80 °C discolouration of the raceways or rolling elements is a frequent feature.

当温度高于 80 °C 左右时，滚道或滚动元件褪色是很常见的特征。