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RESULTS: Thirty-two cases were anencephalia, 31 hydrocephalus, 4 hydroancncephalus, 11 neningocele or encephalomeningocele, 25 spinal meningocele with myeloschisis, 12 Dandy-Walker deformity, 11 schizencephaly of forebrain and 22 choroid plexus cyst among the 148 fetuses. There were different expressions in various CNS deformities, which were correlated with abnormal development of embryo.

结果:148例中枢神经系统畸形胎儿中,无脑儿32例,脑积水3l例,积水性无脑4例,脑膜或脑脑膜膨出11例,脊柱裂脊膜膨出者25例,Dandy-Walker畸形12例,前脑无裂畸形11例,脉络丛囊22例,不同类型的中枢神经系统畸形有不同声像图表现,并与其胚胎发育过程异常相关。

In contrast to hydrocephalus, fetuses with hydranencephaly hae a complete lack of cerebral tissue, and in contrast to anencephaly, there is coering by bone, skin, dura, and leptomeninges(33) Fig.

与脑积水相比较,患有水脑畸形的的胎儿完全缺乏脑组织,而与无脑畸形相比,它有骨、皮肤、硬脑膜和蛛网膜覆盖(图10-26)。

It was comfirmed by CT or MRI among 32 cases. Conclusions Under normal intracranial pressure, if the dura mater is repaired properly at the skull-base defect and reinforced by a pedicled pericranial flap,an encephalomeningocele can be prevented.It is not necessary to take free bone graft when the size of cranial base bone defect is smaller than or equal to 4cm .

手术中只要将颅底正常硬脑膜修补完整,或选用力学性能接近甚至超过正常硬脑膜的材料进行修补,再辅以带蒂颅骨膜瓣等方法加强颅底重建后,术后颅内压不高,在通常的颅底缺损范围内(缺损直径不超过4cm),一般不会发生脑膜脑疝出,不必行颅底骨移植。

They can also arise in endochondral bone; or primitive mesenchymal cells in the brain, meninges, membranous bone, or soft tissue.

它们可以起源于软骨内骨、或者脑内的间充质细胞、脑膜、膜内成骨或者软组织。

The brain is protected in the cranial cavity of the skull and also covered by protective membranses called meninges.

脑位于颅腔内受到保护,外层覆盖着称为脑膜的保护膜。

Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.

结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数和Glasgow预后评分呈负相关;头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查(含压力、蛋白定量、细胞数、HSV-PCR)以及血清酶学的变化和Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。

Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.

结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数与Glasgow预后评分呈负相关;头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查(含压力、蛋白定量、细胞数、HSV-PCR)以及血清酶学的变化与Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。

Objective To explore the diagnosis and treatment of transsphenoidal meningocele.

目的 探讨蝶窦脑膜脑膨出的诊断与治疗。

Combined intra-extracranial approach, which provides excellent exposure and convenient repairing of skull base deficit is an ideal operation for meningoencephalocele.

颅鼻联合入路可提供良好视野,易找到并修复颅底缺损,便于切除颅外膨出部及一期整形,是治疗脑膜脑膨出的理想手术入路。

In the post-treatment groups, dl-NBP(12.5, 25 mg·kg-1 ip) induced dilation of the pial arterioles and the increase in BFV was in dose-dependent manner. The pial arteriolar response to MCAO was not affected by d-NBP and nimodipine.

在脑缺血时,脑微循环障碍是导致神经细胞损伤的主要病理基础之一,所以本研究通过观测NBP对MCAO后软脑膜微循环的影响,进一步分析其抗脑缺血的药理作用机制。

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