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Promoting the synthesis and excretion of endogenous BDNF and GDNF in brain of ICH injury rats, decreasing degeneration and necrosis of neuron after ICH, perhaps there are the important of protecting brain in treating of treating ICH with NYA.

促进脑出血损伤后脑内内源性神经营养因子BDNF、GDNF的合成与分泌，从而减少脑出血后神经元的变性坏死，促进神经修复与再生等，可能是脑溢安治疗脑出血的重要脑保护机制。

We discovered that the mechanisms of borneol opening BBB involved (1) promoting the tight junction of endothelial cells opening:(2) increasing the quantity of pinocytosis vesicle in endothelial cells and enhance the pinocytosis;(3) inhibiting the activation of P-glycoprotein (P-glycoprotein is an efflux pump of drugs) and increase the permeability of BBB;(4) reducing the expression of intercellular adhesion molecule-1 in brain microvessel endothelial cells;(5) increasing the concentration of Ca〓 in brain microvessel endothelial cells;(6) increasing the activation of eNOS in brain microvessel endothelial cells.

随后，在对冰片开放血脑屏障的机制作进一步的研究时又发现，冰片开放血脑屏障的机制包括以下几个方面：(1)冰片可使血脑屏障内皮细胞间的紧密连接开放；(2)冰片能使内皮细胞内的囊泡数量增加，吞饮功能增强；(3)冰片能抑制P-糖蛋白的活性（P-糖蛋白是一种药物外排泵），而使血脑屏障的通透性增加；(4)冰片能使脑微血管内皮细胞ICAM-1表达量减少；(5)冰片使脑微血管内皮细胞内的Ca〓浓度升高；(6)冰片可升高脑微血管内皮细胞eNOS的活性。

objective:to study the changes of dynamic electrocardiogram in patients with brain injury.methods:fifty-six patients with acute brain injury were recruited in this study.the glasgow coma scale, the initial computed tomogram and ambulatory electrocardiogram were performed in all subject.data were analyzed according to different place and severity of brain injury.results:ecg abnormalities were found in 32 patients out of 56 patients with acute head injury(57.14%).

目的：观察脑损伤患者的动态心电图改变，了解急性脑损伤致心电异常的特点及其与损伤部位和严重程度的关系。方法：选取我院急性脑损伤患者56例，经glasgow评分分型，脑ct确定损伤部位，并行24h动态心电图检查，观察急性脑损伤后心电异常的发生情况，并根据脑损伤部位和严重程度分组观察，以了解其心电异常的特点。

Methods 104 patients with chronic cerebral circulation insufficiency were randomly divided into two groups.in basis of routine therapy, patients in treatment group (n=56) were treated by yangxue qingnao granules,4 g,three times a day; patients in control group (n＝48) were treated by troxerutin, 3 pills a day.the course was 30 days in two groups.the indexes of hemorrheology and mca,aca,pca, va, ba and pi were observed before and after treatment.results there were significant differences between two groups in blood viscosity, plasma viscosity, mca,aca,pca,mca and pi after treatment (p.05).conclusion yangxue qingnao granules have definite effect on chronic cerebral circulation insufficiency, and decrease and hemorrheology in patients with ccci, relieve angiospasm and improve clinical symptoms.

将慢性脑供血不足患者104例随机分为2组。在常规治疗基础上治疗组56例加服养血清脑颗粒，每次4 g，每日3次口服。对照组48例在常规治疗基础上加服曲克芦丁，每次2片，每日3次口服。2组均30日为1个疗程。观察2组临床疗效，治疗前后血液流变学指标及大脑中动脉、大脑前动脉、大脑后动脉、左右椎动脉和基底动脉的搏动指数及阻力指数的变化。结果 2组治疗后全血黏度、血浆黏度，mca、aca、pca的pi及mca的ri及总有效率比较差异均有统计学意义(p＜0.05)。结论养血清脑颗粒治疗慢性脑供血不足疗效确切，能降低ccci患者的血液黏稠度及血液流变学指标，增加脑供血，缓解血管痉挛，改善临床症状，改善脑供血不足。

Methods the diagnosis situation of 19 cases of cryptococcal meningitis who have been confirmed from 1980 to 2004 are analysed.results there are 17 misdiagnosis cases in 19 patients, of which 7 cases are tubercular meningitis,3 are viral meningitis,2 are brain tumor,1 is cerebral edema,1 is arachnoiditis of brain and 2 are others.conclusion misdiagnosis can be discreased by promoting learning about cryptococcal meningitis, examining the doubtful patients' csf frequantly and another examinations.

对本院1980—2004年确诊的19例新生隐球菌脑膜炎病人的诊断情况进行回顾分析。结果 19例确诊前有17例被误诊，其中误诊为结核性脑膜炎7例，脑肿瘤2例，病毒性脑膜炎3例，脑水肿1例，脑蛛网膜炎1例，红斑狼疮脑病1例，其他2例。结论提高对新生隐球菌脑膜炎的认识，对可疑病人多次做脑脊液墨汁涂片检查，或其他检查，可减少误诊。

ObjectiveNon-heparinized autohemic arterial blood of the rat was injected into its caudate nucleus to establish a model of intracerebral hemorrhage. The changes of edema in various regions of the brain were measured at different time after hemorrhage. Meanwhile, the effects of erythrocytes and thrombin on the formation of cerebral edema after cerebral hemorrhage were studied to explore the pathophysiological mechanism of cerebral edema and the roles of erythrocytes and thrombin in this process.

目的 利用自体未肝素化新鲜血回注法建立大鼠尾状核出血模型，观察脑出血后不同时间不同部位脑组织水分含量的变化，并分别研究红细胞、凝血酶对脑出血后脑水肿形成的影响，揭示脑出血后脑水肿形成的病理生理机制，并阐明红细胞、凝血酶在脑出血后脑水肿形成中的作用，从而为临床脑出血病人病情评估及治疗提供理论依据。

Specifically when operating Go/No go tasks,the brain blood flow in the areas of anterior cingulated cortex,the medial prefrontal,lateral inferior frontal gyrus and corpus callosum rise dramatically,which implies that deficiency may exist in the functions of these parts of the brain,and depressed patients among college students have the problem of behavioral inhibition in the cognitive aspect, which is connected with certain parts of the brain mechanism.

更多数图谱数据分析方法，发现抑郁症组和正常组间存在相应脑区局部脑血流的显著变化，具体体现在执行Go/No go任务时，前扣带回和前额内侧、额下回外侧和胼胝体区域内的脑血流显著升高，提示这些部位的脑功能可能存在功能性改变，说明抑郁症大学生在认知方面存在行为抑制，而且该问题与特定部位的脑机制有关。

Although classic neuroimaging features of RPLS with involvement of the posterior head regions are easily recognized, features that may generally be regarded as atypical were often present in our patients, such as significant anterior involvement, cortical lesions, recurrent RPLS episodes, foci of permanent injury, hemorrhage into lesions, and unilaterality (Figure 1). High signal intensity on T2-weighted image lesions can occur in regions other than the parieto-occipital areas, frequently involving the frontal lobes, basal ganglia, thalami, or brainstem.

可逆性后部白质脑病综合征典型的神经影像学表现为大脑后部受累，尽管这一点很早就被公认；但可逆性后部白质脑病综合征不典型的神经影像学表现，在本文的患者中则更常见，如：大脑前部明显受累、皮层出现病灶、可逆性后部白质脑病综合征再次发作、脑永久性损伤灶形成、病灶内出血、仅见单侧病灶（图1）；T2像常可于额叶、基底节区、丘脑、脑干等顶-枕叶以外的区域见高信号病灶。

The particular arrangement of veins in the telencephalon permits them to flow in both directions via medullary veins, as seen with certain disorders, such as deep arteriovenous malformations, Sturge-Weber disease, and the developmental venous anomalies[60], possibly explaining the small diameter and unimportance of parenchymal lesions when such a vein is thrombosed.

这种特殊的解剖分布使得端脑内的静脉可以通过脑穿通髓静脉产生双向血流，这一点在脑深部动静脉畸形、Sturge-Weber病/斯特季-韦伯二氏病/脑眼颜面血管瘤病、脑静脉发育异常等疾病中都可观察到，同时也可以解释当这些静脉受累形成血栓时常产生较小的、甚至不容易被发现的病灶。

The early intervention on haematoma surround tissue by early input oxygenised liquid during hypertensive cerebral haemorrhage surgery that could effectively relieve cerebral oedema and improve cerebral ischemic hypoxia to save reversibly injured neurons surrounding haematoma,is an effective intervention, which is helpful to the cerebral protection in the patients with hypertensive cerebral haemorrhage.

在高血压脑出血术中早期输入携氧液对血肿脑周围组织提供早期干预，有效减轻脑水肿，改善脑组织缺血缺氧，挽救血肿周围可逆性损伤的神经元是一项有效的措施，有利于高血压脑出血患者的脑保护。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。