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脑白质

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Objective To analyze the clinical characteristics of metachromatic leukodystrophy and evaluate the diagnostic values of computerized tomography, magnetic resonance imaging and measuring arysulfatase A activity in peripheral leukocytes.

目的 分析异染性脑白质营养不良的临床特征,评价头颅CT、MRI及白细胞芳基硫酸酯酶A对MLD的诊断价值。

Results On CT images,all patients had more or less decrease of the white matter,of whom,10 cases to be only in periphery of trigona regions,other 116 cases to be general minify.

结果CT显示所有患儿均有不同程度的脑白质减少,单纯三角区周围减少10例,普遍减少者116例。

Objective To investigate the pathogenesis of the abnormal diffusion in the white matter tracts in patients with neuromyelitis optica using diffusion tensor imaging.

在视神经脊髓炎(neuromyelitis optica,NMO)患者,脑白质纤维束的扩散异常已有报道,但其分布模式及发生机制尚不清楚[1]。

Most of the patients with neuropsychiatric lupus will have these hyperintense white matter lesions, but so do apparently normal individuals.

大多数神经精神性狼疮患者将具有这些高信号脑白质病变,但是正常个体也会有这些表现。

Human neurotropic JC virus is able to infect human brain glial cells. The causative agent of the fatal human demyelinating disease progressive multifocal leukoencephalopathy, that cytolyses and destroys oligodendrocytes, the myelin-producing cells of the central nervous system. Also results from several experiments have indicated the JCV is able to induce neoplasms.

人类嗜神经性JC病毒可感染人类脑细胞是引起进行性多病灶脑白质病的因素,为一种致命性的脱髓鞘疾病,其导致神经系统产髓质细胞的溶解破坏,但JCV也在许多动物实验上显示其有促成肿瘤的潜在性。

Ross,-P-F concuded, the FB1 in food which concentration was 1mg/g~126mg/g could induce equine leukoencephalomalacia, the concentration which was 1mg/g~330mg/g could induce porcine pulmonary edema syndrome; Schmelz,-E-M concluded 10mmol/L FB1 could induce HT29 cells apoptosis.

Ross,-P-F等经过分析发现,每克饲料中FB1的浓度为1mg~126mg可导致马脑白质软化症,浓度为1mg-330mg/克饲料可导致猪肺水肿;Schmelz,-E-M等经过实验证明10mmol/L FB1可导致HT29细胞出现凋亡。

No significant difference was found between the volumes of GM, right caudate nucleus, globus pallidus, bilateral frontal lobes, anterior cingulate gyri, thalami, hy, and amygdalae in both groups.

结果 与正常对照组相比,OCD患者组的全脑白质、双侧壳核体积增加;左侧尾状核和苍白球体积减小(P<0.05)。

The effect of treatment is negatively correlated with the course of disease, generally, the effect is much worse with the course of disease is much longer; The effect is positively correlated with the course of treatment, it is better if the course of treatment is longer.The group of more than one year is much excellent than the group of less one year. The ex-electroencephalogram before treatment is normal, on edge and a little abnormal, the effect is better. As regards CT or MR result, there is difference between the effective group and the ineffective group. The result of CT and MR is negative, the effect is better, and the effect to demyelination and leukoencephalopathy is most worst.However,for the tipe of much abnormality, the effect is the most worst.The effect is related to course of disease.The effect is better if the course is shorter.There is no difference in the tipe of disease the symptoms before episode, the frequency of episode, the inducing reasons, the age, sex and so on.

病程的长短与疗效存在负相关关系,病程越长疗效越差;疗程与疗效存在正相关关系,疗程越长疗效越好;疗前脑电图的异常程度与疗效存在负相关关系,正常、边缘及轻度异常者,疗效较好,重度异常者疗效最差;无效组与有效组在CT及MR检查结果上有差异,有阴性者疗效好,阳性者疗效差,脱髓鞘及脑白质病疗效最差的趋势;疗效与性别无相关性;无效组与有效组在发作类型、既往病史、辨证分型、发作先兆、疗前发作频率、诱因、发病年龄、就诊前所用药物方面无差异。

Objective:To detect the mutations of ABCD1 gene by denaturing high performance liquid chromatography.

目的:目的对4个肾上腺脑白质营养不良家系进行基因突变分析。

Minor features include dental pits, renal cysts, rectal hamartoma polyps, cerebral white matter migration lines, gingival fibromas, and confetti skin lesions.

辅助特征包括牙齿凹痕、肾囊肿、直肠错构瘤样息肉、脑白质放射移行线,牙龈纤维瘤,斑驳样的皮肤斑。

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