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In the brain of adult rat, the positive immunohistochemical product of lSL-l (ISL-l-positive) was mainly located in the neuronal nucleus and found in discrete regions except to brain cortex, such as the Purkinje cell layer and the granular cell layer of cerebellum, the granular cell layer and the pyramidal cell layer of hippocampus, the mitral cell layer, the internal and external plexiform layer, the granular cell layer and the granular cell layer of olfactory bulb and so on, and several nuclei of the hypothalamus, midbrain and pons, such as claustrum, anterior olfactory nucleus, accumbens nucleus, caudate-ptamen, pallidum, substantia nigra, striatum, islands of Callaje, mammillary nucleus, anterior pretactal nucleus, habenular nucleus, amygdaloid nucleus, cuneate nucleus, rubral nucleus, gigantocellular reticular nucleus and so on.

在正常成年大鼠脑中,同源框基因islet-1表达产物(ISL-1)免疫组织化学阳性物质广泛分布于除大脑皮层外的神经细胞的细胞核内,ISL-1阳性神经元密集分布于小脑Purkinje细胞层和颗粒细胞层、海马的颗粒细胞层和锥体细胞层、嗅球的内丛层、外丛层、颗粒细胞层及僧帽细胞层等,另外在丘脑、中脑和桥脑的一些重要神经元核团均有分布,如,屏状核、前嗅核、伏核、尾壳核、苍白球、黑质、纹状体、Calleja岛、乳头体核、前顶盖前核、缰核、杏仁核、楔束核、红核网状巨细胞核等。

FasL immunopositive neurons were observed in cerebral cortex, especially in pyramidal neurons of lamina Ⅱ and Ⅴ, cerebellar nuclei, diencephalon, and brain stem nuclei involving pontine nucleus, vestibular nucleus, cochlear nucleus, spinal nucleus of trigeminal nerve, hypoglossal nucleus, nucleus ambiguous and reticular formation.

间脑中有FasL阳性神经元分布。在脑干,Fas主要分布于前庭神经核、迷走神经背核和三叉神经脊束核的神经元;FasL广泛分布在脑桥核、前庭神经核、三叉神经脊束核、舌下神经核、蜗神经核、网状结构和疑核。

The fibres of the corticospinal tract, which run craniocaudally in the dorsal pons, the pontine tegmentum, and the superior cerebellar peduncles ventrally, were all preserved, this differential involvement therefore being responsible for the cruciform appearance on MRI.

译:脑桥神经元和横桥纤维严重减少,造成脑桥基底部和小脑中脚的苍白和萎缩。上下走行于脑桥背侧的皮质脊髓束、脑桥背盖部、腹前侧的小脑上脚/结合臂均未受累。这种差异性受累是MRI上出现十字征的原因。

Results showed that after injection of HRP into medial recteus subnucleus of oculomotor nucleus,HRP labelled cells were found in contralateral abducens nucleus and also in vestibular nucleus and pontine ...

结果表明:注射HRP于大鼠动眼神经核内直肌亚核后,在对侧展神经核区以及前庭神经核、脑桥旁正中网状结构中发现HRP单标记细胞;在前庭神经核内,可见HRP单标记、GABA阳性和HRP/GABA双标记三类神经元,其中HRP/GABA双标记细胞占HRP标记细胞总数的47.1%。

The most intense immunoreactivity is found in the central body, the newly described precerebral bridge, and the neuropil surrounding of the central body and the mushroom bodies (except for three pairs of optic tubercles). Fainter immunoreactivity appears in the mushroom bodies, postcerebral bridge and three pairs of optic tubercles; The calyces show the weakest immunoreactivity.

中央体、脑前桥及中央体与蕈形体周围的髓质区具有较强的阳性反应;蕈形体和脑后桥和三对视突次之;蕈形体冠5-HT阳性反应最弱。

Methods: The anatomic construction of the cerebellopontile angle and the relationship of VN and its surrounding nerves and vessels were observed under microscope .

在手术显微镜下观察了52例前庭蜗神经瘤病人的桥脑小脑角剖结构及VN与周围神经、管的解剖关系。

Results By means of adjusting the angle of microscope, the structures were exposed of ipsilateral cerebellopontile angle, anterior and lateral regions of the pons, and supratentorial area of the cerebellum.

结果通过调整显微镜角度,幕上下乙状窦前迷路后锁孔入路可显露同侧桥小脑角区、桥前区、桥侧方、脑幕上区的结构。

From the brain stem at the lateral end of ponto medullary sulcas, the distance between the facial nerve, the vestibulocochlear nerve, the abducenst nerves, and the trigeminal nerve were 2.38±0.65mm, 6.62±0.41mm, 7.59±1.08mm.

面神经在桥延沟的外端起自脑干,与其外侧的前庭蜗神经进入脑干处相距2.38+0.65mm,距外侧展神经6.62±0.41mm,距三叉神经7.59±1.08mm。

In the pontocerebellar space, when CT plain scan were enhanced, the infarctional vessel obviously became thicken, which was reliable

例,CT 平扫见桥脑小脑间隙处一个长条环状血管影。增强时,其阻塞血管明显增粗、致密强化,这是诊断小脑前下动脉梗塞的

There were no significant differences for the firing rates in the site of contralateral TNC neurons among during pre-CSD,CSD,and post-CSD (P>0.05).For flunarizine group,the firing rates in the site of ipsilateral TNC neurons during pre-CSD were higher as compared with during CSD(P<0.05).2.1 There were statistical differences on palasma levels of CGRP and SP among the three groups(P<0.05).The levels of CGRP and SP in CSD group were higher than control group(P<0.05).No significant differences on the levels of CGRP and SP in ipsilateral trigeminal ganglia were found among the three groups(P>0.05).2 The number of neurons with positive CGRP and SP immunoreactivity was statistically different in right-sided trigeminal ganglia among the three groups (P<0.05).The number in fight-sided trigeminal ganglia in CSD group was higher as compared with control group(P<0.05).The number in right-sided trigeminal ganglia was statistically higher than that in left-sided trigeminal ganglion in CSD group(P<0.05).3.1 Altered ReHo in ipsilateral pons and other brain regions response to pain such as basal nuclei,thalamus,cingulated gyms and prefrontal cortex was detected during the acute spontaneous attack as compared with during headache remission(P<0.05,corrected by Monte Carlo simulation). 2 Positive functional connectivity was detected between ipsilateral pons and other brain regions related to pain within pain state and within non-pain state (P<0.05,corrected by false discovery rate,FDR).Increased functional correlation between ipsilateral pons and other pain-related brain regions such as ipsilateral prefrontal cortex and contralateral subcallosal gyrus was detected during the acute spontaneous attack as compared with during headache remission(P<0.05,corrected by Monte Carlo simulation).

结果1。对照组未发现CSD;同侧TNC放电频率,CSD中>CSD后>CSD前P<0.05对侧TNC放电频率,CSD前、中、后无统计学差异(P>0.05氟桂利嗪组同侧TNC放电频率,CSD前>CSD中(P<0.05),CSD前与CSD后及CSD中与CSD后之间无统计学差异(P>0.05)。2.1关于放免测定,各组血浆CGRP、SP水平有统计学差异(P<0.05),CSD组高于对照组(P<0.05),CSD组与氟桂利嗪组、对照组与氟桂利嗪组之间均无统计学差异P>0.05各组之间同侧三叉神经节中CGRP、SP水平未见变化(P>0.05.2关于免疫组化研究,右侧三叉神经节CGRP、SP免疫阳性细胞数三组之间有统计学差异(P<0.05),多重两两比较结果CSD组大于对照组(P<0.05),CSD组与氟桂利嗪组之间、对照组与氟桂利嗪组之间无统计学差异P>0.05左侧三叉神经节CGRP、SP免疫阳性细胞数三组之间无统计学差异(P>0.05CSD组中右侧三叉神经节CGRP、SP免疫反应阳性细胞数大于左侧(P<0.05)。3.1局部一致性分析发现两组患者头痛疼痛状态较非疼痛状态脑活动发生变化的脑区有同侧脑桥以及其他疼痛相关脑区如基底节区、丘脑、扣带回、前额叶皮层等(P<0.05,蒙特卡罗模拟校正)。2功能连接分析发现疼痛状态与非疼痛状态下主要疼痛相关脑区均与同侧脑桥有功能联系P<0.05,false discovery rate,FDR校正疼痛状态与非疼痛状态比较,同侧前额叶皮层、对侧胼胝下回等疼痛相关脑区与同侧脑桥之间功能联系增强(P<0.05,蒙特卡罗模拟校正。

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Lao Qiu is the Chairman of China Qiuyang Translation Group and the head master of the Confucius School. He has committed himself to the research and promotion of the classics of China.

老秋先生为中国秋阳翻译集团的董事长和孔子商学院的院长,致力于国学的研究和推广。