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脑损伤

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Free radicals formation and lipid peroxidation were thought to potentiate ischemic brain cell injury.

脑缺血细胞损伤的原因之一为自由基大量形成和脂质过氧化的病理过程。

Methods Serum putrescine,spermidine and spermine were measured by using HPLC in 16 cases of cerebral infarction and 26 controls.

脑缺血时存在明显的聚胺代谢紊乱,且其与缺血性脑细胞损伤的密度密切相关 [1] [2 ] 。

Results there were unconsciousness, respiratory rhythm disturbance and hyporeflexia of pupil light reflex immediately after injury, and reactiveness decrease and activity retardation still existed even after resuming consciousness. at anatomical scene, subarachnoid hemorrhage or cerebroventricular haemorrhage were widespread. at an early stage, there were swelling, collapse, and axonal retraction ball formation at cortico-medulla junction, callosum, brainstem, and cerebellar white matter under microscope. but at the later stage, gitter cell proliferation and nest-like aggregation were major pathophysiological changes at focal brain tissue.

结果 伤后大鼠均即刻出现原发昏迷,其中2只于损伤后20 min内死亡,余持续时间1-30 min不等;伤后大鼠呼吸节律紊乱,瞳孔对光反射减弱或消失,醒后均有程度不等的反应性下降,肢体活动迟缓;肉眼可见广泛蛛网膜下腔出血或脑室出血;光镜下可见皮髓交界区、胼胝体区、脑干、小脑白质等部位的神经轴索有不同程度的肿胀、断裂、轴索球形成,后期有小胶质细胞增生,局部呈巢样聚集。

The experiment concentratedly study the influence of Bushen Huoxue Huatan Prescription from multilateral and multilager in treating the dementia rats whose cholinergic nerve cells are injured.The study has suggested that the deficiency of essence Qi of kidney and insufficiency of brain marrow and the blood stasis and phlegm located in brain is the fundmental pathogenesis of begin prostatic hyperplasia, thus we bring forward the referentially experimental basis for the prevention and treatment of Alzheimers disease.

实验从多侧面、多层次集中研究了补肾活血化痰方对胆碱能损伤痴呆大鼠产生的影响,首次揭示了老年性痴呆"肾虚髓减,瘀血痰浊阻脑"病机理论的科学内涵,从而为老年性痴呆的预防和治疗提供了可供借鉴的实验依据。

AFGF shows greatpotential for clinical applications for therapy of a variety of diseases, such as Parkinson'sdisease, spinal cord contusion injury, neural regeneration in reimplantation of broken-offfinger, brain ischemia, renal ischemia, myocardial infarction, occlusive vascularitis, retinalischemia, gastric ulcer and nonhealing wound and so on. We expressed human acid fibroblast growth factor gene transiently in tobacco byAgro-bacterium mediated vacuum infiltration and studied the factors, which influenced theexpression level.

人类酸性成纤维细胞生长因子(aFGF,FGF-1)是成纤维细胞生长因子超家族成员,来自于三个胚层的多种细胞都可以表达aFGF.aFGF在治疗帕金森综合症、急性脊柱扭曲性损伤、断指中神经功能重建、脑缺血、肾缺血、心肌梗塞、闭塞性脉管炎、视网膜缺血、胃溃疡及难愈合性伤口等多种临床应用方面具有巨大潜力。

The increased expression of HIF-1α participate in the injury and reparative process in the brain.

脑内神经元的损伤和修复过程中HIF-1α表达增加,参与了毛细血管通透性升高的过程。

Therefore,when formulating the programme of intracranial tumor resection,it is not only to resect the tumor to the greatest extent,but also to avoid the injury of the important function area in the brain and relevant area of the cerebral white matter,and thus to enhance the quality of patients′ life after surgery.

因此在制定颅内肿瘤切除的方案时,不仅要最大限度切除肿瘤,还要注意术中尽量避免脑的重要功能区及相关白质纤维束的损伤,从而提高患者术后的生活质量。

Objective:To observe the protective effect of tea saponin on Focal cerebral ischemia-reperfusion injury.

目的 观察茶皂素对大鼠局灶性脑缺血再灌注损伤的保护作用。

The morphological change alleviated and GFAP expression keeping high in astrocytes at 72h after cerebral ischemia. The results of cell culture show that IL-8 would increase the number of astrocytes and do not scathe neurons.

脑缺血后72hAS表达GFAP仍高同时脑组织中IL-8水平升高,并伴随受损神经元修复;说明GFAP表达及IL-8可能在神经元的抗损伤中具有作用。

However, in many patients with brain and spinal cord disorders, spasticity can interfere with functional mobility and activities of daily living.

然而,许多脑和脊髓损伤的患者,痉挛影响活动和妨碍日常生活。

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