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They are already being evaluated in clinical trials as potential therapeutic agents for major human neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and motor neuron disease. However, delivery of polypeptide growth factors to compromised neurons in the CNS is problematic because their plasmatic half-life are very short and their abilities to cross the blood-brain barrier are theoretically null.

然而由于中枢神经系统中存在血脑屏障,神经营养因子类物质难以通过血脑屏障而到达靶部位;同时又因为神经营养因子在体内生物半衰期较短,使得全身性用药效果不够理想,另外还往往产生意想不到的副作用,如何解决这些问题对于深入研究神经营养因子在神经损伤及神经系统退行性疾病中的作用及开展临床应用前景研究有着十分重要的意义。

Large craniectomy may reduce the case fatality. The prolonged coma may increase, while the palinesthesia rate was also increased. Although some complications were more common in large craniectomy group, such as porencephalia and subdural fluid collection, they can be treated by cranial orthopedics or V-P shunt and the patient still has better long-term life quality.

采用大骨瓣开颅减压术治疗重型颅脑损伤,远期病死率较低;早期昏迷发生率虽有所增加,但复苏率明显高于对照组;慢性脑积水、脑穿通畸形发生率增加,但通过采取积极治疗,如早期颅骨成形、脑脊液分流术等可获得较好的疗效,因而远期生活质量较对照组好。

Results tRPJS significantly decreased the contents of NOS and iNOS in hippocampus region of MCAO rat and cerebral ischemia reinfusion mouse.

结果 tRPJS能显著降低脑缺血再灌注损伤小鼠和局灶性脑缺血大鼠海马组织NOS、iNOS的含量(P.05)。

Objective To determine the inhibitory effect of safflor injection on the level of serum interleukin-8 (IL-8) following cerebral ischemia and reperfusion injury in rabbits.

目的观察红花注射液对脑缺血/再灌注损伤家兔血清白细胞介素-8(IL-8)水平的影响,并探讨其脑保护机制。

Microsurgery cerebelli tentorium inciseon and local application of papaverine could take effect on reducing brain

显微手术天幕缘切开、罂粟碱明胶海棉片贴敷能够彻底解除脑干受压、防治血管痉挛进而减轻由此引发的脑干继发性损伤,降低病残率和死亡率。

Apoptosis may be also involved in the pathogenesis of neuronal death induced by this thrombotic ischemic lesion.

血栓性脑缺血损伤中存在细胞凋亡现象及凋亡相关基因Bc1-2、Bax的表达,细胞凋亡也参与了血栓性脑缺血所致的神经细胞死亡过程。

Compared with other advanced techniques employed in cognitive neuroscience, studies on brain-damaged patients have a long history and unique contribution to the field Specifically, the selective disruption of some task performance signifies the functional independence of a cognitive component subserving that task. The double dissociation between two functions further suggests the dissociation, possibly both functionally and anatomically, of two components.

某些脑伤病人的选择性认知能力损伤,说明了和该作业相关的认知成分在功能上的独立;两个功能的双重分离,更显示其组成成分可能在行为功能和生理解剖上有不同的机制,以致其中一者单独被脑伤所影响、而另一者则保存完整。

Objective To investigate the levels of nitric oxide and nitric oxide synthase in asphyxia neonatorum and its significance on prognosis judgments.

一氧化氮及一氧化氮合成酶作为血管舒缩调节剂,在脑缺血或脑缺血再灌注损伤中具有不同的作用,包括保护作用及毒性作用[1] 。

METHODS Anesthetized rats undergone 10min light irradiation on exposed skull after rose bengal injection were pretreated with saline and Dex at 3 doses 12.5, 25, and 50 mg.kg-1, ip, 15 min before ischemia.

采用光化学脑缺血模型,在缺血前15分钟,腹腔注射12.5, 25, 50 mg.kg-1的右美沙芬,观察对损伤区体积、局部脑血流量和bcl-2bax表达的影响。

To approach its" mechanism of action, we carded out this experiment. The SD rats were objects in this experiment. We made rat focal cerebral ischemia model with middle cerebral artery occlusion using a thread block technique. We gave a mark of the neurologic impairment in rat and detected the contents of calcitonin gene-related peptide and neuropeptide Y in rats" cornu ammonis and brain mantle respectively by electro-acupuncture on shuigou(DU 26) acupoint. In this way, we are trying to explore the mechanism of acupuncture therapy in cerebral ischemia.

为了进一步探讨其作用机理,本实验以SD大鼠为研究对象,采用线栓法制作大鼠局灶性脑缺血模型,运用电针水沟进行治疗,并对大鼠神经功能缺损进行评分,检测了大鼠海马及大脑皮质降钙素基因相关肽以及神经肽Y含量,从中枢神经肽类递质的变化探讨电针抗脑缺血损伤的作用机理,为临床治疗缺血性脑血管疾病提供实验依据。

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