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Cytokines are small soluble proteins with pleiotropic effects on a variety of cell types.

脑血管疾病是神经系统的常见病和多发病,脑梗死引起脑缺血损伤是最主要的脑血管疾病。

Radiosensitive genes of gliomas and apoptosis, cell cycle transformation,DNA damage induced by irradiation and DNA repair promoted by them are suggested to be associated with glioma radiosensitivity.

脑胶质瘤内在的放射敏感性基因及其引起的细胞凋亡、细胞周期的变化和放射线导致的DNA损伤修复等,都与脑胶质瘤的放射敏感性密切相关。

The microglial cells appeared the ramified and rod figuration in the early stages of cerebral ischemia and in the border zone of infarct.

采用侧脑室注射缝隙连接特异阻止剂甘珀酸,测定其对脑梗塞灶体积的影响及对即刻早期基因FOS和GFAP表达的影响,以了解缝隙连接在脑缺血损伤中的作用。

RMF may prevent and treat focal cerebral ischemia/ reperfusion injury in rats.

旋磁场对大鼠局灶性脑缺血再灌注损伤具有预防和治疗作用,此作用可能与减轻脑水肿,提高超氧化物歧化酶的活性,降低丙二醛的含量有关。

Electroencephalogram is an effective technology which has been used widely to detect the activities of brain without scathe. It has some advantage over PET, fMRI due to its higher time resolution, easier operation and less expensive.

脑电图检测是一种被广泛应用的无损伤脑功能测量技术,并且较之PET、fMRI等脑功能成像技术具有时间分辨率高、易操作、设备价格低廉等优点。

Results Compared to the controlled groups,the lungs in cerebral hemorrhage groups existed hemorrhage,serosity exudation and inflammation infiltration(including macrophage and leucocyte),and the number of macrophage an...

结果与对照组比较,脑出血组肺组织存在明显渗出、出血及大量白细胞、巨噬细胞浸润,炎症细胞记数有显著意义P.05。结论脑出血可以通过引发炎症反应导致急性肺损伤;炎症反应在3~5d时最明显。

To detect effects on apoptosis of cortex neuron in DHCA rats, the rat model of occluding bilateral common carotid artery in the deep hypothermic (21C) rats had been established, and flow cytometry, TUNEL, electron microscope, immunohistochemistry and RT-PCR had been studied.: part I: To establish a new rat model of cerebral ischemia/protect during DHCA: 20 SD rats were used in the experiment, little animal respirator was to assist anesthetized rat's respiration after tracheal cannula, artery press through artery spile in femoral artery, electrocardiograph, temperature, blood saturation of O2 (SaO2) and arterial blood gases were monitored during the whole experiment, blood flow of bilateral common carotid artery of rat were occluded about 60 minute when its temperature was reduced to 21 C by ice, then normal temperature was resumed.

本研究采用大鼠深低温颈总动脉阻断模型,应用流式细胞仪、电镜、原位缺口末端标记法、免疫组化法和RT-PCR技术分别检测深低温脑缺血对皮层神经细胞调亡的影响方法:第一部分深低温停循环脑保护大鼠模型的建立:SD大鼠20只,麻醉后气管插管辅助呼吸,用冰块将大鼠的体温降至(21±1)℃,阻断双侧颈总动脉,记录体温、心率、血压、血氧饱和度和血气分析,60分钟后恢复颈总动脉血流,用Longa等的5级评分标准评定4小时和24小时后大鼠神经系统损伤情况。

12H treatment group compared with 12h model group: the level of MCP-1 of the Gardenoside group decreased and MIP-1 is no different with the model group; the level of the MCP-1, MIP-1 of the Baicalin group are no different with the model group; the level of MCP-1, MIP-1 of the Concha Margatitifera Usta decreased than the model; the level of MCP-1 of the Cholic Acid group is no different and the level of MIP-1 decreased than the model; the level of MCP-1 of the Hefang Group decreased and the level of MIP-1 of it decreased than the model group.

合方治疗脑缺血24小时组缺血脑组织nNos光密度值较缺血24小时模型组明显降低(p<0.01)。细胞的死亡分为坏死和凋亡两种方式,凋亡是细胞为避免对机体造成更大损伤而采取的一种程序性的死亡方式。珍珠母、胆酸、栀子苷、黄芩苷、合方治疗组较脑缺血24小时模型组可明显降低P53阳性表达,考虑药物抑制细胞凋亡可以起到对缺血脑组织的保护作用。

With a model of reversible middle cerebral artery occlusion in rats, the effects of Losartan on the water content of the brain, the contents of Evens blue and the expression of MMP9 were investigated after 24 hours of reperfusion following two hours of cerebral ischemia.

采用血管内栓线阻断法制备大鼠局灶性脑缺血再灌注损伤模型,于脑缺血2?h、再灌注24?h后测定脑组织含水量、伊文斯蓝含量,免疫组织化学方法测定MMP9表达。

With a model of reversible middle cerebral artery occlusion in rats, the effects of Losartan on the water content of brain, the contents of Evens blue and the expression of MMP-9 were investigated after 24 hours of reperfusion following two hours of cerebral ischemia.

采用血管内栓线阻断法制备大鼠局灶性脑缺血再灌注损伤模型,于脑缺血2h、再灌注24h后测定脑组织含水量、伊文斯蓝含量,免疫组织化学方法测定MMP9表达。

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