脑

The top of neural tube forms basic encenphalic shape,namely endbrain, interbrain, midbrain and afterbrain. The abnormal closure of neural tube will result in neural tube detects. Encephalocoele is a common congenital malformation whose mechanism was no known. NO participates in the physiologic process of brain.

胚胎脑发育的早期阶段主要是神经板隆起、弯曲、闭合形成神经管，神经管的头部从前向后依次发育形成脑的基本组织形态，即端脑、间脑、中脑、后脑，在神经管闭合过程中出现异常就会导致NTD。

When the amount of SO(superscript 2- subscript 4)/ZrO2 catalyst was 7% of the mass of β-pinene, the yield of product was 62.0%, and the mass ratio of borneol to isoborneol in the product was 13.6:48.7. When the amount of S2O(superscript 2- subscript 8)/ZrO2 catalyst was 7% of the mass of β-pinene, the yield of product was 66.7%, the mass ratio of borneol to isoborneol in the product was 11.5:49.5. Both two catalysts were poor for borneol selectivity.

在上述反应条件下，当催化剂SO(上标 2-下标 4)/ZrO2用量为7%时（以β-蒎烯质量计，下同），粗龙脑产率为62.0%，产品中正、异龙脑比为13.6：48.7；当催化剂S2O(上标 2-下标 8)/ZrO2用量为7%时，粗龙脑产率为66.7%，正、异龙脑比为11.5：49.5；这两种催化剂对正龙脑选择性比较差。

Results: Compared with IR group , XSOL could significantly decrease the cerebral water content, the cerebral index, the brain vascular permeability in rats of acute incomplete brain ischemia-reperfusion (P.01,P.05). Cerebral tissue morphology showed that neuronic damage of rats subjected to acute incomplete brain ischemia-reperfusion was ameliorated following administration of XSOL (2.4, 9.6g/kg). Compared with IR group , XSOL could significantly decrease the content of MDA and NO in brain tissue(P.01,P.05)and increase SOD,GSH-px activity. The levels of cerebral Glu,Asp were cut down(P.01,P.05). Conclusion: XSOL shows protective effects on cerebral ischemia-reperfusion.

结果：与缺血再灌注组比较，XSOL大、小剂量组可以显著降低急性不完全性脑缺血再灌注模型大鼠的脑含水量(P.01，P.05)、脑指数(P.01，P.05)、脑毛细血管通透性(P.01，P.05)；光镜下脑组织形态学显示各剂量组可不同程度的减轻急性不完全性脑缺血再灌注大鼠脑组织的神经元受损形态；与缺血再灌注组比较，XSOL大、小剂量组可以显著降低缺血再灌注大鼠脑组织中的MDA的含量(P.01，P.05)，升高SOD、GSH-Px在脑组织中的活性(P.01，P.05)；XSOL大、小剂量组可显著降低脑组织中NO的含量(P.01，P.05)，降低脑组织中Glu、Asp含量(P.01，P.05)。

In particular, it is unknown how the relevant neural substrates function as a network to mediate perspective-taking during the task requiring understanding other's belief. The current work first developed a new psychological paradigm that excludes potential confounds such as the processing of language, biological motion, episodic memory and causal coherence in the paradigms used in previous studies. I recorded neural activities associated with mental inference task using functional magnetic resonance imaging and electroencephalography in order to investigate the functional roles of several brain areas (i.e. precuneus, MPFC, etc.) that engage in understanding other's belief. I also proposed a computational model based on the neuroimaging results that simulated the neurocognitive mechanism underlying cortical dynamics in correct judgment of other's belief.

本文首先发展了一个新的心理学实验范式，排除以往常用&错误信念&范式中与语言加工、生物运动、情景记忆及事件连续性和因果性等方面的混淆，采用功能磁共振成像（functional magnetic resonance imaging， fMRI）和脑电（Electroencephalography， EEG）时频分析等脑成像技术，记录与理解他人信念任务相关的神经活动，通过对行为和脑成像数据的分析，研究楔前叶和内侧前额叶等脑区在理解他人信念任务中的功能意义，并根据脑成像结果，提出一个基于自我和他人视角竞争的计算模型，模拟大脑在理解他人信念时做出正确决策时的认知神经机制。

Result: Compared to normal subjects, some functional regions associated with encoding, maintenance and retrieval process showed increased activation in schizophrenia patients, i.e. right precuneus for encoding process, left PMA, left DLPFC, right precuneus and left VLPFC for maintaince process, left PMA for retrieval process. In addition, subcortical structures, primary motor cortex and some verbal regions in left temporal lobe also showed more activation.

结果：与正常组比较，患者组工作记忆不同认知过程的执行脑区激活程度增加，编码期激活增加脑区为右侧楔前叶，维持期激活增加脑区为左侧PMA、左侧DLPFC、右侧楔前叶及左侧VLPFC，提取期激活增加脑区为左侧PMA，而且患者组还激活了更多皮层下结构、初级运动皮层及左侧颞叶语言相关脑区。

Although classic neuroimaging features of RPLS with involvement of the posterior head regions are easily recognized, features that may generally be regarded as atypical were often present in our patients, such as significant anterior involvement, cortical lesions, recurrent RPLS episodes, foci of permanent injury, hemorrhage into lesions, and unilaterality (Figure 1). High signal intensity on T2-weighted image lesions can occur in regions other than the parieto-occipital areas, frequently involving the frontal lobes, basal ganglia, thalami, or brainstem.

可逆性后部白质脑病综合征典型的神经影像学表现为大脑后部受累，尽管这一点很早就被公认；但可逆性后部白质脑病综合征不典型的神经影像学表现，在本文的患者中则更常见，如：大脑前部明显受累、皮层出现病灶、可逆性后部白质脑病综合征再次发作、脑永久性损伤灶形成、病灶内出血、仅见单侧病灶（图1）；T2像常可于额叶、基底节区、丘脑、脑干等顶-枕叶以外的区域见高信号病灶。

After reperfusion for 12h, TNF-α, IL-1β, ICAM-1mRNA and expression of theirproteinum increase in model group compared with sham operated group and decrease intreated group, that proved clearing brain and releasing orifices dripping pills with heat-clearingand detoxicating effect could lessen the acute cerebral ischemia damage through inhibiting the inflammatory reaction.

急性脑缺血再灌注12h后，和假手术组相比模型组大鼠TNF-α、IL-1β、ICAM-1蛋白和mRNA均增高，应用清脑宣窍滴丸干预后均有不同程度降低，表明清热解毒活血开窍作用的清脑宣窍滴丸可能通过抑制急性脑缺血炎症反应减轻急性脑缺血损害。

The particular arrangement of veins in the telencephalon permits them to flow in both directions via medullary veins, as seen with certain disorders, such as deep arteriovenous malformations, Sturge-Weber disease, and the developmental venous anomalies[60], possibly explaining the small diameter and unimportance of parenchymal lesions when such a vein is thrombosed.

这种特殊的解剖分布使得端脑内的静脉可以通过脑穿通髓静脉产生双向血流，这一点在脑深部动静脉畸形、Sturge-Weber病/斯特季-韦伯二氏病/脑眼颜面血管瘤病、脑静脉发育异常等疾病中都可观察到，同时也可以解释当这些静脉受累形成血栓时常产生较小的、甚至不容易被发现的病灶。

The early intervention on haematoma surround tissue by early input oxygenised liquid during hypertensive cerebral haemorrhage surgery that could effectively relieve cerebral oedema and improve cerebral ischemic hypoxia to save reversibly injured neurons surrounding haematoma,is an effective intervention, which is helpful to the cerebral protection in the patients with hypertensive cerebral haemorrhage.

在高血压脑出血术中早期输入携氧液对血肿脑周围组织提供早期干预，有效减轻脑水肿，改善脑组织缺血缺氧，挽救血肿周围可逆性损伤的神经元是一项有效的措施，有利于高血压脑出血患者的脑保护。

Neural stem cells have a strong self-renew mechanism and it can transform after a little break. Neural stem cells have a long term survival, which mean that it has more probability of wrong copy than mature cells. These cells are formed glioma stem cells in the end. The genes who adjust neural stem cells can express in glioma stem cells, which hold out glioma stem cells from neural stem cells. There is another presume that glioma stem cells come from differentiated cells. Through the gene break of these cells, they can obtain characteristics of stem cells, then form glioma stem cells.

神经干细胞具有很强的自我更新机制，获得较少突变即有可能恶性转化，而且干细胞存活时间较长，这意味着干细胞比成熟细胞发生细胞复制的错误几率更大，因外界环境的刺激而发生突变的机会更多，最终形成脑胶质瘤干细胞，同时调节神经干细胞增殖和自我更新的基因在脑胶质瘤的脑胶质瘤干细胞中也表达，这也是支持神经干细胞是脑胶质瘤干细胞来源的；也有推测认为它可能起源于已分化的细胞，由这些细胞突变发生去分化得来，并通过基因突变而获得了干细胞自我更新的特性，从而形成脑胶质瘤干细胞。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。