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However, we observed distinct abnormalities within presynaptic terminals of spinal MNs at the neuromuscular junction, as well as profound denervation.

无论如何,我们观察到神经肌肉接头处的脊髓运动神经元突触前末梢的明显的异常,还有显著的去神经支配。

Objective: To explore the characteristics of the synaptic transmission from contralateral ventrolateral funiculus to motoneurons in neonatal rat spinal cord slices.

目的:了解对侧腹外侧索至离体脊髓运动神经元突触传递的细胞电生理特性和介导递质。

Expression in spinal motoneuron resulting from spinal root avulsion

1在脊髓运动神经元中微量表达。

Objective To study the effect of dexamethasone on the recovery of motor neuron in anterior horn of spinal cord following sciatic nerve injury.

目的 观察地塞米松对大鼠坐骨神经损伤后脊髓运动神经元形态学的影响。

The pathways that regulate tone are similar to those that regulate voluntary and involuntary motor movements and, as a final common pathway, involve the spinal reflex arc.

控制张力的传导通路和那些控制随意或非随意运动的通路是一样的,即脊髓反射弧,这是一个最后的公共通路:控制肌纤维的α运动神经元位于脊髓前角,发出反射弧的传出纤维,源自肌梭的传入冲动经由Ⅰa纤维传向脊髓,这些直接与α运动神经元连接的轴突中的一部分激活主动肌。

This study demonstrates that the degrade excitability of dynamoneure may be internal mechanism of electric acupuncture cure hemiparalysis of spasmodic limbs after cerebral infarction.

降低脑梗死后脊髓α运动神经元兴奋性可能是电针治疗脑卒中后偏瘫肢体痉挛的内在机制之一。

It is reported that retrogradely tansported Ⅰ〓-NTs, CNTF to ventral horn cells greatly increased and can be blocked by excess non-labelled NTs, CNTF, suggesting that the increased transport of NTFs were mediated via the receptors.

有文献报道,坐骨神经损伤后外源性CNTF可诱导脊髓运动神经元CNTF受体的高表达。

Get the neonate Sprague-Dawley rats medulla spinalis, through the conventional primary cell culture procedure, we use the method of difference adherence time and get the motor neurons of anterior spinal cord. When the neuron is in maturity, we make the mechanical injury model in vitro. All the models were divided into four groups: group A is control group; group B is 100μM ATP group; group C is 100μM ATP+20μg/ml suramin group and group D is 100μM ATP+10μM ouabain+10μg/ml Thapsigargin group. Culture the four groups neurons, after one day, we count the motor neuron, observe the survival and activity of neurons through MTT shade selection experiment, use flow cytometry to analyze the percentage of apoptosis of motor neurons of anterior spinal cord and detect the expression of protein p-GSK-3β(ser9) through Western-Blot technology.

方法取新生大鼠脊髓,通过常规的原代细胞培养程序,采用差速贴壁法分离出大鼠脊髓前角运动神经元,培养成熟后制作神经元机械损伤体外模型,分为A组:对照组、B组:100μMATP组、C组:100gMATP+20μg/ml Suramin组和D组:100μM ATP+IOμM Ouabain+10μg/ml Thapsigargin组,对各组机械损伤的运动神经元进行培养,1天后分别进行运动神经元计数、MTT比色实验观察运动神经元的存活及活性、流式细胞仪分析机械损伤的脊髓前角运动神经元凋亡百分率和Werstern Blot技术检测p-GSK-3β(ser9)的表达。

Objective: To observe the effect of valproic acid on bcl-2 expression and motor neuronal apoptosis in spinal cord of rats following sciatic nerve transection.

目的:观察丙戊酸钠对鼠坐骨神经切断后脊髓运动神经元凋亡及Bcl-2基因表达的影响。

The number of spinal motoneurons continued to decline in the first 3 months postoperativdy and plateaued after three months.

脊髓前角运动神经元数目在3个月内持续减少,3个月后趋于稳定,6个月时脊髓前角大型运动细胞坏死比率在40%左右,残存的神经元多为受损的神经元,尼氏体减少或消失。

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