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In normal group and sham lesion group, BDA positive neurons were distributed symmetrically in the pyramid cells of sensorimotor cortex, and BDA positive fibers of pyramid cells passed through the cerebral cortex, internal capsule, cerebral peduncle of midbrain, basilar portion of pons to the pyramid of medulla oblongata. At the lower part of the medulla oblongata, most of the BDA positive fibers passed through the pyramidal decussation to the contralateral side, continously descended at the ventral part of posterior funiculus just dorsal to the posterior gray commissure and ended at sacral spinal segments.

正常组和假损伤组大鼠BDA示踪显示BDA标记阳性细胞定位于双侧感觉运动皮层的锥体细胞,锥体细胞发出的BDA阳性纤维束对称分布于双侧皮层、内囊、大脑脚、脑桥基底部、延髓锥体中的皮质脊髓束内,继而经锥体交叉到脊髓后索,在双侧后索最深层、灰质后连合背侧下行至脊髓骶段。

In the normal rats (n=5、6), CGRP-LI were mainly present in small and some medium-sized neurons and the primary afferent fibers and ter- minals in laminae Ⅰ,Ⅱ,Ⅴ,Ⅹ and Lissauer's tract of the spinal cord; GAL- and SP-LI were mainly present in small neurons and the superficial layers of the dorsal horn. After the adjuvant injection both CGRP-and SP-LI were in- creased corresponding to the development of arthritis. On day 2, CGRP-and SP-LI were moderately increased in laminae Ⅰ,Ⅱ and the posterior commis- sure of the spinal cord and small neurons in DRG, while SP was obviously in- creased in the superficial layers and DRG. On day 14, CGRP-LI were marked- ly enhanced in the above regions with the development of polyarthritis. Some- times many strongly stained long fibers could be seen in the posteriot commis- sure.

在DRG中,CGRP主要分布于小和中等神经元之中,SP和GAL主要分布于小神经元之中;2、注入弗氏完全佐剂(含冻干结核菌0.5mg)后第2天动物(各5~6例)产生具有明显红、肿、热、痛和痛敏的急性关节炎,免疫组化实验观察到注射侧脊髓背角和DRG中CGRP-和SP-LI明显增加;在佐剂后第14天,动物患肢肿胀、痛敏和自发痛均进一步加重,部分动物健肢也出现红肿,产生多发性关节炎时,脊髓背角浅层和DRG中CGRP-和SP-LI增加更为明显,并且在灰质后联合中可见许多深染的CGRP-LI长纤维;在佐剂后第21和28天,随着佐剂性关节炎的逐渐恢复,脊髓背角和DRG中CGRP-和SP-LI也接近正常。

Especially, the number of type Ⅰ complex terminals which come from unmyelinated afferent fibers recovered to the level of unoperated side. It indicates that morphine may promote the collateral sprouting and synaptic reinnervation of primary afferent fiber, unmyelinated afferent in particular. 4. Although the collateral sprouting and synaptic reinnervation were shown also in spinal cord of operated side in 34 days spared root rats, they were slower than that of morphine spared root group.

表明吗啡促进了备用根初级传入纤维,特别是无髓纤维更快地向L〓脊髓段侧支出芽,稍后在L〓平面脊髓内侧支出芽以及突触重建。4、34天备用根大鼠术侧脊髓内也有侧支出芽和突触重建,不过侧支出芽的速度要比吗啡组慢。5、电镜定量结果也显示,吗啡备用根大鼠和备用根大鼠术侧备用根的无髓纤维数比备用根大鼠非手术侧的分别增多60%和42%。

Objective: To explore the changes on expression of NT-4 and IGF-I in spared dorsal root ganglia (DRG, L6) in operated/acupuncture side and unoperated /unacupuncture side, spinal lamina II (L3, L5, L6) and Clarke' nucleus (L3) of normal adult, partial dorsal rhizotomy and acupuncture spared DRG cats so as to know the relation between NT-4, IGF-I and the plasticity of spinal cord as well as acupuncture promoting spinal cord plasticity.

目的:探讨NT-4和IGF-I在正常猫、部分去背根猫及针刺部分去背根猫的L_6背根节和脊髓Ⅱ板层(L_3、L_5、L_6)与背核(L_3)表达的时空变化,以了解该两因子在脊髓可塑性及针刺促进脊髓可塑性中的关系。

Injury of T12 spinal cord was induced by modified Allen"s method , the rats" restitution of kinesalgia and sensation function was valued by combine behavioral score and the expression of c-fosmRNA and BDNFmRNA was observed by situ hybrization and image quantitative analysis.

采用改良的ALLEN'S撞击法致大鼠T_(12)脊髓损伤,应用CBS联合运动评分判定脊髓损伤后大鼠运动、感觉功能的恢复情况,同时应用原位杂交方法及图像定量分析法观察脊髓损伤后c-fosmRNA和BDNFmRNA的表达。

Spinal neurological involvement was defined by the neurological examination findings suggestive of spinal localization such as paraparesis, sensory deficits indicating a spinal level and sphincter and/or sexual dysfunction or a combination of them.

本研究收集了自1984年以来我院神经白塞病中心收治的所有白塞病脊髓受累患者;所有患者均符合国际白塞病研究小组确定的白塞病诊断标准;同时,通过检查有无脊髓定位体征如截瘫、感觉平面、括约肌和/或性功能障碍等,来确定患者是否有脊髓受累。

Rats were conflicted to a spinal cord contusion by using a modified Allen′s method.SCBF were measured by hydrogen clearance preinjury and 1、4、8、24、72、168 hours after injury. The spinal cord motor evoked potentials were recorded by Konrad′s method and the motor function on the inclined plane was measured at the same time.

Allen′s法致伤大鼠脊髓,于伤前和伤后1、4、8、24、72、168h和1个月,采用氢清除法测量脊髓血流量,参照Konrad的方法记录脊髓运动诱发电位,应用斜板试验评价大鼠的运动功能。

Because evoked potential can reflect integral function of spinal cord and centre nerve system, it is widely applied to estimate spinal cord function, especially in intraoperative spinal cord monitoring during spinal surgery.

诱发电位可以反映脊髓和中枢神经系统功能的完整性,因此广泛地用于评价脊髓功能,特别是用于脊柱外科手术过程中的脊髓损伤监护。

Because evoked potential can reflect integral function of spinal cord and centre nerve system, it is widely applied to estimate spinal cord function, especially in intraoperative spinal cord monitoring during spinal surgery.

摘要诱发电位可以反映脊髓和中枢神经系统功能的完整性,因此广泛地用于评价脊髓功能,特别是用于脊柱外科手术过程中的脊髓损伤监护。

Objective To study the time course change of nerve growth factor and its receptor tyrosine kinase A in a rat model of spinal cord decompression sickness, and explore to the auto nerve protective mechanism.

目的 观察大鼠脊髓减压病后脊髓组织内神经生长因子及其受体酪氨酸激酶A蛋白表达随疾病进程的变化过程,探讨减压病脊髓损伤后自身的神经保护机制。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

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但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。