脊髓中央管

Expression of islet-1 in spinal cord of adult rat.In grey of the spinal cord of adult rat, the results of both of ISL1 immunohistochemistry and islet-1 mRNA in situ hybridi-zation showed that islet-1 gene expressed predominantly in the nuclei of motoneurons in ventral region and some cell around central canal and dorsal region. In white of spinal cord, the expression of islet-1 located in astroglia in anterior and dorsal funiculus.

在正常成年大鼠脊髓灰质中，ISL-l免疫组化和islet-lmRNA原位分子杂交结果都显示islet-1在腹侧角运动神经元中有相当强度的表达；在中央管周围和背侧角胶状质也有islet-1阳性表达细胞存在；在脊髓白质中，islet-l在腹侧索和背侧索中的星形胶质细胞有表达，外侧索相对较少。

Neuronal cell bodies and fibers with moderate mGluR7-LI were seen in the olfactory bulb,anterior olfactory nucleus,piriform cortex,septofimbrial nucleus,bed nucleus of the strial terminalis,lateral hypothalamic area,paraventricular hypothalamic nucleus,supramammillary nucleus,medial and lateral mammillary nuclei,most part of the thalamus,medial and lateral geniculate bodies,nucleus of the optic tract,red nucleus,substantia nigra,interpeduncular nucleus,pontine nuclei,lateral parabrachial nucleus,superior olivary complex,nucleus of the trapezoid body,motor nucleus of the trigeminal nerve,facial nucleus,ambiguus nucleus,cochlear nucleus,vestibular nuclei,nucleus of the solitary tract,hypoglossal nucleus,prepositus hypoglossal nucleus,medullary reticular formation,Purkinje cells of the cerebellum,nucleus raphe obscurus,intermediolateral nucleus of the spinal cord,Onuf′s nucleus and lamina X of the spinal cord.

呈中等强度染色的神经元胞体和纤维见于嗅结节、前嗅核、梨状皮质、隔伞核、终纹床核、下丘脑外侧区、下丘脑室旁核、乳头体上核、乳头体内、外核、丘脑大部分核团、内外侧膝状体、视束核、红核、黑质、脚间核、桥核、臂旁外侧核、上橄榄复合体、斜方体核、三叉神经运动核、面神经核、疑核、耳蜗核、前庭核簇、楔束外核、孤束核、舌下神经核、舌下神经前置核、中缝隐核、延髓网状结构、小脑蒲肯野细胞层、脊髓中间带外侧核、Onuf核和中央管周围灰质。

RESULTS: The positive staining cells mostly included ependymal cells of myelocoele, glial cells, motor neurons, and epithelial cells of spinal pia mater. The staining was mainly located on the cell membrane. Most importantly, it displayed certain directivity in the glial cells, mainly at the membrane side contacting with capillary endothelial cells.

结果： 免疫组织化学染色结果显示阳性着色细胞包括有胶质细胞、中央管室管膜上皮细胞、脊髓前角运动神经元、软脊膜上皮细胞，着色部位主要在细胞膜，其中在胶质细胞表现出一定的方向性，主要分布在与毛细血管内皮细胞接触的一侧。

RESULTS: The clinical manifestations and MRI information of 123 cases verse-type herniation, clinically manifested as symmetric incomplete as central canal syndrome and significantly decreased or lost motility of the ripheral-type herniation, manifested as nerve root pain of unilateral side as well as pain sensation and thermesthesia on the opposite side.

MRI分为横型突出58例，临床表现呈四肢对称性不全瘫痪。②MRI呈中央型突出34例，临床表现呈中央管综合征，双上肢肌力显著减退或丧失。③MRI呈旁侧型27例，临床表现呈不典型性半脊髓综合征。④MRI呈边缘型4例，临床表现为一侧神经根性痛，对侧痛温觉障碍。

From 136 to 138, the expres- sion retrieved ventrally and expressed at the ventral half of the central tube (137) and the ventral horn especially in motor neurons (E7 and E8). Thus, the dorsal terminating axons relating to nociception and thermore?

到民至 Es麻Sema 3A的mRN的表达向腹侧撤退，主要在脊髓中央管周围的腹侧和前角运动神经元，这样使背侧投射性的痛温觉神经元轴突仅进入脊髓后角第 I、11层而不进一步向腹侧投射。

Results: During the development of spinal cord. NIDD mRNA was highly expressed at embryo 16 d and at postnatal 1 d, and co-localized with nNOS in the undifferenti ated ventral horn, as well in white matter. And then it decreased significantly till postnatal 12w. nNOS mRNA was highly expressed from postnatal 1 d to 3 d. The high expression of NIDD mRNA appeared at the 8 hour after spinal cord injury, and co-localized with nNOS in neurons of ventral horn, intermedial zone, the area around central canal and dorsal horn, and recovered to the normal at dry 7 day after SCI.

结果：大鼠发育过程中，胚胎16 d的大鼠脊髓中可见NIDD mRNA的高表达，在生后1d，与nNOS共表达于尚未分化成熟的前角，在白质也见NIDD的阳性信号成年后呈低表达；nNOS mRNA于生后1~3 d出现表达高峰；脊髓损伤后NIDD mRNA表达明显增多，在8 h到达高峰，分布于脊髓前角，中间带、中央管周围及后角nNOS阳性的神经元，7 d恢复至正常水平；nNOS mRNA在损伤后8 h达到高峰，1 d降低至正常水平。

Following these behavioral responses, the NOS expression was up- regulated in the pericentral canal region of the L5 segment of the spinal cord.

伴随着这些行为反应，脊髓L5节段中央管周围灰质区NOS表达上调。

Pre- treatment with spantide depressed the spontaneous flinches of the injected paw in the second phase of the formalin test. At the same time, the upregulation of NOS was substantially inhibited.

2预先给予spantide能抑制大鼠甲醛试验第二时相注射侧肢体的自发性退缩反射，同时抑制了脊髓中央管周围灰质区NOS表达的上调。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失