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Oculocutaneous albinism type 4 (OCA4) is characterized by hypopigmentation of the skin and hair plus the characteristic ocular changes found in all other types of albinism, including nystagmus; reduced iris pigment with iris translucency; reduced retinal pigment with visualization of the choroidal blood vessels on ophthalmoscopic examination; foveal hypoplasia associated with reduction in visual acuity; and misrouting of the optic nerves at the chiasm associated with alternating strabismus, reduced stereoscopic vision, and an altered visual evoked potential.

疾病特征: 4型眼皮肤白化病(OCA4)的特点是皮肤和头发的色素减退以及所有白化病类型都有的典型的眼部改变,包括眼球震颤、虹膜色素减少而使其呈半透明状、视网膜色素减少而使得脉络膜血管在眼底镜检时可见、与中央凹发育不全导致的视敏度降低以及视神经交叉处路径错误引起的交替性斜视、立体感降低和视觉诱发电位改变。

Aside from a diffuse chorioretinal atrophy of the posterior poles in both eyes, direct visualization of the orbital vessels was made through a posterior staphyloma in the right eye.

经眼底检查发现,除了双眼后极有广泛的视网膜及脉络膜的退化之外,患者右眼后葡萄肿里可以直接看见眼窝的血管。

RESULTS: Eight affected subjects had subnormal visual acuity due to high myopia. The results of colour vision tests were consistent with red-green CVD in six of these affected subjects. Fundus examination showed degenerative myopic changes characterized with generalized chorioretinal atrophy.Abnormal cone and rod dark-adaptation and diminished cone response in ERG were found in two subjects. According to family pedigree, it has been suggested that red-green CVD has X-linked recessive inheritance.

结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。

Subthreshold micropulse diode laser treatment can shorten a laser pulse limits, reduce the spread of photocoagulation damage caused by heat conduction during a laser exposure, avoid chorioretinal scars which could expand or increase the risk of iatrogenic choroidal neovascularisation and improve long term visual prognosis.

黄斑水肿的治疗近年来得到广泛的关注,成为研究的热点,但各种新方法的并发症和疗效尚存在一定的争议,阈下微脉冲半导体(810nm)激光治疗黄斑水肿,减少激光曝光持续时间和使用不可见激光斑,能降低可见光凝斑本身对黄斑区视网膜脉络膜的损害,减轻黄斑水肿和提高视力。

The temperature response of laser induced retina and choroids is analyzed in theory.

为了避免激光经瞳热疗带来的热损伤或治疗不足,建立了眼底层状模型并采用二维有限元法求解生物传热方程,从理论上分析了激光引起的视网膜和脉络膜的温度变化。

Theexpression of M_1 and M_4 subtype receptor in the retina, choroids and posterior sclerawere detected with immunohistochemistry and the mRNA level of two receptors inthe three tissues were examined via RT-PCR.

实验结束后,通过RT—PCR对各组巩膜、脉络膜和视网膜内M_1和M_4亚型受体的mRNA水平进行检测,同时使用免疫荧光法检测两种受体在各个组织中的表达情况。

Vitrectomy allows us to manage otherwise untreatable ocular pathologies, but the substitution of the vitreous by an artificial intraocular irrigation solution would probably disturb the physiology of the retina and choroids.

随着玻璃体切除术的出现和日益发展,眼内灌注液作为术中使用的玻璃体替代物,直接影响视网膜和脉络膜的正常生理功能。

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