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To observe the choriocapillaris closure during hematoporphyrin mono methyl ether photodynamic therapy in New Zealand rabbits in order to investigate whether HMME-PDT can be used to treat aging macular degeneration.

观察血卟啉单甲醚光动力疗法对家兔脉络膜毛细血管的封闭作用及对视网膜非选择性损伤的特点,探讨HMME是否能够选择性引起脉络膜毛细血管的闭合,达到治疗老年性黄斑变性的目的。

Research background: Choroidal neovascularization is a common cause of vision loss in patients, which often resulted from exudative Age-related macular degeneration、 pathologic myopia、 central serous chorioretinopathy、ocular histoplasmosis and angioid streaks, Rarely, CNV is seen in children, usually in association with inherited macular dystrophies. Despite extensive basic and clinical research, our knowledge of the complicated molecular mechanism of CNV is still limited, for these reasons currently used therapeutic approaches are insufficiently effective.

课题研究背景:脉络膜新生血管(choroidal neovascularization,CNV)是导致视力丧失的一种常见原因,多继发于渗出型年龄相关性黄斑变性、近视性黄斑变性、中心性浆液性脉络膜视网膜炎、眼组织胞浆菌病和眼底血管样条纹等眼病,在儿童罕见,主要与遗传性黄斑营养不良有关,尽管近年来进行了大量的基础和临床研究,但对CNV复杂分子机制的认识仍然非常有限,因此目前的治疗措施都不尽如人意。

Abstract] Objective To assess a new imaging technique,optical coherence tomography,for the diagnosis of central serous choroidoretinopathy.Methods Forty-five cases (45 eyes) of CSC were examined by ophthalmoscopy,binocular indirect ophthalmoscopy and OCT.Some patients were monitored by OCT.

摘要] 目的评价光学相干断层成像(optical coherence tomography,OCT )对中心性浆液性脉络膜视网膜病变的临床诊断价值方法对45例(45眼)中心性浆液性脉络膜视网膜病变患者散瞳后分别进行直接检眼镜、双目间接检眼镜、OCT 检查。9例复查时再次进行OCT检查。

There is a tapetum which reflects light of hyaline layer between the chorioidea and pigament epithelium.

脉络膜毯是脉络膜和色素上皮之间的折射透明层,为动物适应弱光下增进视力的装置。

Clinical and experimental study of Transpupillary thermotherapy Choroidal neovascular is the most common characteristics of...

脉络膜新生血管的形成是多种常见眼底病的共同特征,如:年龄相关性黄斑变性、中心性渗出性脉络膜视网膜病变、病理性近视等。

TTT is effective for the treatment of choridal disease and has few complications.

TTT对脉络膜疾病临床疗效肯定,副作用少,是一种很有潜力的脉络膜新生血管、血管瘤的治疗方法。

The chief changes were the RPE and choriocapillaris atrophy in FFA and ICGA with the MPPE in quiescent phase, but the choroidal circulation anomalies disappeared including the choroidal filling delay and dilated.

静止期MPPE患者在FFA和ICGA中的荧光改变则主要为RPE和脉络膜毛细血管的萎缩,而脉络膜血管充盈迟缓和血管扩张等循环异常变化基本消失。

Chorioretinal eaxminations of pathologic myopia show complicated features, and the multiple CNV causes severe damage to the visual function. FFA can provide the evidences for the clinical intervention.

病理性 近视视网膜脉络膜呈现复杂多样的病变特征,尤其是脉络膜新生血管多发危害大,FFA为临床干预治疗提供依据。

Fundus photographs showed myopic chorioretinal atrophy in eight study eyes (47%), including diffuse atrophy in four eyes (24%) and patchy atrophy in four eyes (24%). The IS/OS defects on FD-OCT were accompanied by myopic chorioretinal atrophy in three (60%) of five eyes.

眼底成像显示8只眼(47%)有近视性脉络膜视网膜萎缩,其中包括4只眼(24%)为弥漫性萎缩,4只眼(24%)为斑块状萎缩。5只眼中有3只眼(60%)的傅立叶域光学相干成像显示为光感受器内外节缺损伴随近视性脉络膜视网膜萎缩。

Althought this surgery has been reported by a few doctors recently, the safety and effectiveness need to be evaluated in further studies. In our study, the approach of the chorioretinal venous anatomosis in the model eyes with branch retinal vein occlusion, are induced by different surgical anastomosis procedures, in order to invest the effectiveness and safety and make a pilot clinic treatment exploration. Methods and materials The study was divided two ports: animal experiment and clinical study.

这种治疗方法的可行性和疗效评价,在激光诱导脉络膜视网膜静脉吻合术治疗非缺血型CRVO病人中得到证实;而对缺血型CRVO,由于病情严重,晚期新生血管并发症产生的危险性高,或者已有产生,因此最近开展的用玻璃体切除联合手术吻合脉络膜视网膜静脉的外科治疗作为最新的探索性治疗方法,在国外已见少数病例报告,但是尚需要进一步的研究观察来评价其可行性、安全性和疗效。

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