脂酶

In order to understand the mechanism of anti-inflammatory effect of PA and carvacrol, the superoxide dismutase, glutahoine reductase, glutahoine peroxidase activities in liver and malondialdehyde , cyclooxygenase 2 (COX-2), tumor necrosis factor-α levels were eveluated. Also observed inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) expression and the pathological histology in λ-carrageenan induced paw edema in mice.

本研究首先以醋酸扭体试验评估左手香水抽提物及其活性成分香芹酚是否具有镇痛效果，以福马林舔足试验辨别其镇痛作用是在周边或是中枢，再以λ-角叉菜胶诱导小鼠足跖肿胀试验探讨其抗发炎作用，并分析其肝脏组织中的超氧歧化酶、麸胱甘肽还原酶、麸胱甘肽过氧化酶活性、发炎足跖组织中的脂质过氧化指标产物丙二醛、肿瘤坏死因子-α及环氧化酶-2之含量变化，观察诱导型一氧化氮合成酶及环氧化酶-2之蛋白质表现量，并将肿胀足跖做病理切片观察之，以探讨左手香水抽提物及香芹酚之抗发炎机转。

Methods Fifty-three patients diagnosed as chronic hapatitis of C were treated by IFN and Ribavirin for at least 24 weeks. Serum HCV-RNA was detected by fluorescent quantitative PCR. Genotype was determined by Simmonds. Results There was no difference of HCV-RNA levels in different genotypes, as that of ApoB.

临床确诊为慢性丙型肝炎的53例患者，采用干扰素联合利巴韦林抗病毒治疗至少24周，Simmonds酶切分型方法进行HCV基因分型，荧光定量聚合酶链反应法定量检测HCV-RNA，全自动生化分析仪检测血清载脂蛋白B，对不同基因型患者血清HCV-RNA水平和载脂蛋白B的关系进行研究分析。

LPL was expressed in many tissues in tree shrew, highly in cardiac muscle and adipose tissue. In despite of no expression in skeletal muscle, there was less-medium expression in liver, distinctly different from human LPL which was expressed in the contrary way in these two tissues.

树鼩脂蛋白脂肪酶的组织表达谱比较广泛，在心肌和脂肪组织中大量表达，但在骨骼肌中未检测到，却在肝脏中有中低水平表达，与人脂蛋白脂肪酶在这两种组织中的表达相反。

Congenital ichthyosis and psoriasis. Therefore, further investigation into the relationship between 12R-LOX, eLOX3 and skin barrier, as well as the development of novel drugs targeting on these genes would provide new ideas and methods for the treatment of xerosis and development of moisturizers.

深入研究12R-脂氧合酶和表皮型脂氧合酶3与皮肤屏障的关系，以及研发选择性作用于二者基因靶点的新型药物将为某些干燥性皮肤病的治疗和保湿类化妆品的开发提供新的思路和方法。

It was suggested that the pharmacodynamics and therapeutic function of Qizhi complex prescription to fatty liver were: 1. Adjust lipometabolism: reducing TC and TG; 2. Decreasing fatty degeneration of liver cell; 3. Promoting the convalescence of hepatocellular function; 4. Anti-lipid peroxide: increasing the activation of peroxidase, decreasing the content of products of lipid peroxide. 5. Restraining Kupffer cell function of fatty liver rat; 6. Improving fluidity of hepatocellular microsome and mitochondria.

芪枳合剂治疗脂肪肝的效应及药效学机制为： 1、调整脂质代谢：降低血清甘油三脂和胆固醇； 2、减轻肝细胞脂肪变性； 3、促进肝细胞功能恢复，有效治疗脂肪性肝炎； 4、抗脂质过氧化：提高抗氧化酶活性、降低脂质过氧化产物含量； 5、抑制脂肪肝大鼠Kupffer细胞功能； 6、改善肝细胞微粒体、线粒体膜流动性。

The results showed that ACP positive reactions were mainly deposited in lysosome, nucellar cell, cellular endomembrane, mitochondriurn, and endoplasmic reticulum in four tissues of the healthy shrimp. Furthermore, ACP activity was located in microvilli, and around partly lipid droplet in liver. AKP positive reactions were mainly deposited in cell membrane, nucellar cell, lysosome. endoplasmic reticulum and cellular endomembrane in four tissues.

结果显示，在健康的对虾体内，ACP依次出现在各组织中的溶酶体、细胞核、细胞内膜、线粒体、内质网以及肝脏组织中的部分脂滴周围及微绒毛中AKP依次出现在各组织中的细胞膜、细胞核、溶酶体、内质网以及肝脏组织中的脂滴周围及微绒毛中。

Changes of serum concentration of LDL-C,HDL-C,LPO and LDH isoenzymes have been studied in 35 cases of esophagus cancer,13 cases of lung cancer and 5cases of breast cancer before radiotherapeutics and chemotherapy.

本文对未进行放疗及化疗的53名癌瘤患者(食管癌35例、肺癌13例、乳腺癌5例)进行了血清脂蛋白亚组分中胆固醇含量(LDL-C、HDL-C)及脂质过氧化物和乳酸脱氢酶同工酶的研究。

After lock out of the 5LO gene by homologous recombination in embryonic stem cells, 5LO deficient-mice can develop normally and stay healthy, with a selective opposition to certain inflammatory insults. The cellular distribution of 5LO in unstimulated cells among different cell types is different; it can present in the cytosol, the nucleus, or both.

采用同源重组方式敲除胚胎干细胞中的5-脂氧合酶基因，小鼠能正常生长和发育，但对某些炎症损伤的反应性与正常小鼠不同。5-脂氧合酶在不同的细胞中表现出不同的亚细胞定位，分布于胞质或胞核，或两者都有。

Recent studies have shown that 12R-LOX and eLOX3 take part in terminal keratinocyte differentiation via arachidonic acid pathway, regulate the formation, development and function of, affect the appearance and structure of skin barrier, and play important roles in the pathogenesis of many dermatoses e.g.

近年来研究发现，12R-脂氧合酶和表皮型脂氧合酶3可以通过花生四烯酸代谢途径参与皮肤的终末分化，调节皮肤屏障的发育、形成、功能及影响其外观与结构，并且在先天性鱼鳞病、银屑病等皮肤病发病机制中起作用。

In contrast, the 6 months therapy with pravastatin in combination with ubiquinone Q10 (60 mg daily) sharply decreased the LDL initial lipoperoxides level whereas during treatment with cerivastatin in combination with probucol (250 mg daily) the LDL lipoperoxides concentration was maintained on an invariable level.

方法与结果：维生素400mg/d治疗三个月未降低LDL氧化易感性；普罗布考250mg/d3-6个月治疗未改变血液脂质代谢参数，但显示了强抗氧化性；普伐他汀40mg/d或西立伐他汀0.4mg/d治疗6个月，体内脂质过氧化物大量聚集；普伐他汀和辅酶Q（60mg/d）联合用药能够大大降低LDL脂质过氧化水平；西立伐他汀与普罗布考（250mg/d）联用对LDL脂质过氧化水平无明显影响。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。