脂质

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

Results The optimum preparation formulation:drug/PC:1∶30,liposomes were pH 7.4 outside and incubated at 30℃.The encapsulation rate of Vinorelbine Bitartrate in liposomes was above 85%.

结果 制备重酒石酸长春瑞滨脂质体的最佳条件是药物与磷脂的质量比为1∶30，胆固醇与磷脂质量比为1∶4，脂质体外水相pH值最终调至7.4，孵育温度为30℃，此时的包封率可以达到85%以上。

Objective To prepare vinorelbine bitartrate liposome and compare the difference of the entrapment efficiency by using Sephadex minicolumn centrifugation method and cation exchange resin centrifugation method, respectively.

目的 制备重酒石酸长春瑞滨脂质体，比较葡聚糖凝胶微柱离心法和阳离子交换树脂离心法测定重酒石酸长春瑞滨脂质体包封率的差异。

Methods The vinorelbine bitartrate liposome was prepared by pH gradient method. Sephadex G-50 and cation exchange resin could entirely separate free vinorelbine bitartrate from liposomes. The concentration of vinorelbine bitartrate was determined by HPLC. The result was analyzed with SPSS.

pH梯度法制备重酒石酸长春瑞滨脂质体，分别以葡聚糖凝胶Sephadex G-50和阳离子交换树脂装柱，离心分离脂质体和游离药物，采用HPLC法测定药物含量，计算包封率，并用SPSS软件进行t检验。

Brucine and its liposome could inhibit the growth of transplanted solid tumor and the inhibitory effect of its liposome is much stronger than that of brucine.

马钱子碱及其脂质体有显著的抑制荷瘤小鼠肿瘤生长作用，马钱子碱脂质体抗肿瘤作用明显强于马钱子碱。

The main differences in chemical compounds related to the taste and flavorbetween cultured and wild prawns may be summerized as follows: 1 The content of quaternary bases in the extractives of wild prawn is higher than that of cultured prawn; 2 The content of fatty acids, C18:2ω6 is higher in the cultured prawn; 3 Many thiazole compounds were found in the odor concentrate of cultured prawn, azulene was found in the odor compounds of wild prawn; 4 The textrue of cultrued prawn meat is relatively weak.

综上所述，养殖对虾与天然对虾的尝味比较中主要差别是提取物组分的有机碱；对虾肌肉脂质比较结果是养殖对虾肌肉脂质中C18：2ω6含量特别高；对虾挥发性成分结果是养殖对虾中有大量的噻唑化合物，天然对虾存在薁类化合物；两类对虾质地比较的结果是养殖对虾质地不及天然对虾。

The result indicates the t-BHP or diamide both cause the mass loss about the membrane protein thiol in hepatocytes, the fast oxidization about glutathione in hepatocytes, the leakage of lactate dehydrodenase, but the level of t-BHP is larger than of diamide. In the aspect of lipid peroxidation, only the t-BHP produces apparent change. As to actin and tubulin, they both find fall-off and present time-dependency effects. The result in Confocal fluorescent microscope also show these two cytoskeletal proteins are related to cell blebbing, but they don''t play the same role during the porcess. Tubulin may be more important than actin. If the study predispose dithiothreitol before adding t-BHP or diamide, then the damage by the diamide is repressed, but just partly protection for the damage by t-BHP.

结果显示t-BHP或diamide均可造成细胞膜蛋白硫醇大量流失与胞内GSH快速氧化，亦显著导致乳酸去氢□渗漏，但t-BHP诱发的渗漏程度大於diamide；在脂质过氧化方面，则仅t-BHP处理组产生明显的脂质氧化情形；至於肌动蛋白与管蛋白单体均可见减少且呈现时间依赖效应；在雷射共轭焦萤光显微镜观察中，亦显现这两种架构蛋白与细胞膜起泡有关，但两者在小泡生成的过程中扮演的角色并不完成相同，可能管蛋白较肌动蛋白重要；如果细胞在t-BHP或diamide加入前预先以dithiothreitol处理，则diamide 所造成的伤害显著的受到抑制，但DTT对t-BHP所诱发的伤害则仅有部分保护效果。

Results: in control group, there were no atherosclerotic changes on endarterium; in model group, there were obviously atherosclerotic changes on endarterium, in "National pits1573" 520、450、380 Alcohol group and 450 control Alcohol group, there were unconspicuously atherosclerotic changes on endarterium.

结果：空白对照组主动脉内膜未见粥样硬化改变；模型组主动脉内膜粥样硬化斑块形成，部分斑块病灶范围较大；45°对照酒组仅见少量散在脂质条纹；"国窖1573"52°、45°组，仅见轻度主动脉粥样硬化改变；38°组，主动脉壁见散在少量小范围脂质条纹。

Aim To prepare resveratrol liposome and the liposomes modified by a galactoside as well as to investigate and compare their liver targeting effect.

目的 制备白藜芦醇脂质体和半乳糖苷修饰的白藜芦醇脂质体，探讨并比较二者的肝靶向作用。

In the group of treatment with ZKK,the AST,ALT and the lipid in the liver decrease significantly and differ from the natural recovery group'sbut the normal group's.In the group of treament with Simvastatin,the affection to the ALT,AST and the lipid in liver is no apparent,there is no difference campared to that of recovery group,but very difˉferent from that of treatment group with ZKK,In the combined treatment group,the effect to decrease the bloodlipid is significant,the influence on liver is similar to the ZKK's.Conclusion Rich-fat food can induce dyslipidemia,atheromatous patch and hepar adiposum.

辛伐他汀组对成模时增高的ALT、AST和肝组织中的脂质及脂肪肝影响不大，与模型组相比无差别；之可康组和联合治疗组均可明显降低成模时升高的AST和ALT及肝组织中的脂质，逆转脂肪肝，与正常组相比无差别，与模型组、辛伐他汀组分别相比差异有显著性；联合用药组血脂水平调节幅度最大，对肝脏的影响与之可康组相比无差别。3个治疗组均可使动脉硬化斑块回缩。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。