脂血症

Objective To assess the current status in dietary treatment of hypercholesterolemia and its effects on control of this disease in China.

目的 了解接受调脂药物治疗的高胆固醇血症患者膳食状况及膳食对高胆固醇血症控制状况的影响。

ConclusionNew criteria of plasma lipid values in children in Beijing are established by our investigation in 971 healthy school students.Age and sex have been analyzed.Borderline and high of TC and LDLC levels have been settled.Cutoff of hypertriglyceridemia and hypohigh density lipoprotein cholesterolemia have also been established.

结论通过对971名北京市中小学生的血脂调查，建立了北京地区不同年龄性别儿童青少年的血脂正常值，确立了临界高胆固醇和高胆固醇血症浓度、高甘油三酯血症浓度和低高密度脂蛋白浓度。

The data shoewed that esculetin, resveratrol enhanced LPL expression up to about 1.2 ~3.5 fold compared with the control group. In addition to fibrates, however, no effect on LPL expression by curcumin was observed. We concluded that esculetin and resveratrol enhanced LPL expression on CHO-K1 cell. We hope that we can apply these drugs to mutant form LPL, furthermore apply theses drugs into clinical treatment.

利用药物处理有转染带有完整人类脂蛋白解脂酶启动子和脂蛋白解脂酶cDNA 序列(-1715 ~+1643)质体的CHO-K1细胞，从细胞培养液以及细胞溶解物中发现，除了curcumin之外所有药物都可以使得细胞培养液以及细胞溶解液内的脂蛋白解脂酶活性有1.2至3.5倍的上升，由此结果可知除了curcumin外，esculetin和白藜芦醇以及其他fibrate药物可降低三酸甘油脂血症。

The improved puberty PCOS-IR rat model has following characteristic:Retained the high androgen syndrome and/or the high LH syndrome as the endocrine characteristics;Simultaneously it had sugar fat metabolism unusual, such as the insulin resistance,the redemptive high insulin blood sickness as well as cholesterol ascension.Has the abdomen obese characteristic----In particular fat pad which around reproductive organ obvious increased;The ovary increased obviously,Ovarian cortex accumulated,the number in ovary pouch expansion graafian follicle were remarkable increased, ovulation suppression.

一、改良青春期PCOS-IR大鼠模型具有以下特征：1、保留了高雄激素血症和/或高LH血症等内分泌特征；同时有胰岛素抵抗，代偿性高胰岛素血症以及总胆固醇升高的糖脂代谢异常。2、具有腹部肥胖的特征——尤其是生殖器周围脂肪垫明显增加；3、卵巢明显增大，皮质增厚，卵巢内囊性扩张卵泡数目显著增加，排卵抑制。

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物，包括其药学上可接受的盐和前药，它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物，特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物，这些症状包括肥胖病和脂质疾病，比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。

The increased VLDL in hypertriglyceridemic patients is mainly ApoE poor VLDL subfraction.

高甘油三酯血症患者血中升高的极低密度脂蛋白主要是贫含载脂蛋白E的亚组份。

The effects of Lecithin on reducing LDL cholesterol and increasing HDL cholesterol makes it useful in the treatment of atherosclerosis, hypercholesterolaemia, hyperlipidaemia, Coronary heart disease and hypertension.

的影响，卵磷脂对降低低密度脂蛋白胆固醇，增加高密度脂蛋白胆固醇，使有益的，在缓解动脉粥样硬化，高胆固醇血症，高血脂症，冠心病及高血压。

Vascular obstruction of the microcirculation may be caused by fat emboli, related to hyperlipidemia associated with alcoholism, steroid therapy, SCD, and nitrogen bubbles in decompression sickness.

血管阻塞的微循环可能造成的脂肪栓子，与高脂血症与酗酒，类固醇治疗，猝死，氮泡沫减压病。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。