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脂蛋白

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Lipoprotein lipase gene is a multifunctional protein, which catalyses the hydrolysis of the triglycerides component of Chylomicrons and very low density lipoproteins.

脂蛋白脂酶是一种多功能蛋白,其主要作用是催化乳糜微粒和极低密度脂肪酸的甘油三酯水解,是影响脂肪沉积的关键酶之一。

Diabetes ; Radix Astragali ; Serum index ; High density lipoprotein cholesterolemia ; Low density lipoprotein cholesterolemia ; Insulin

糖尿病;黄芪;血清学指标;高密度脂蛋白胆固醇;低密度脂蛋白胆固醇;胰岛素

Methods Rabbit model was adopted with gallstone induced by high cholesterol diet. Dynamic study on the serum lipoprotein cholesterol, hepatic total cholesterol, bile cholesterol and glycocholate, and low density lipoprotein recepter activity of hepatocytes had been conductd for the test and control groups after 1,2,3 and 4 weeks respectively.

采用高胆固醇膳食诱发兔胆囊结石模型,对进食高胆固醇膳食后1,2,3,4周实验组和对照组血清脂蛋白胆固醇、肝脏总胆固醇、胆汁中胆固醇和甘氨胆酸,肝细胞低密度脂蛋白受体活性变化进行了动态研究。

Methods: Foty healthy New Zealand white rabbits were randomly divided into four groops. Control groop was fed with normal diet for 10 weeks, model groop was fed with 1.5% cholesterol diet plus normal diet; APS groop was fed with 1.5% cholesterol plus 12.0mg/kg APS plus normal diet; Captopril groop was fed with 1.5% cholesterol plus 15.0mg/kg Captopril plus normal diet. After ten weeks' experiment, the concentration of each group's Triglyceride, Total Cholesterol, High Density Lipoprotein Cholesterol, C Reactive Protein, Nitric Oxide, Maleic Dialdehyde and Endothelin-1 were measured, so was the activity of superoxide dismutase.

将40只雄性新西兰兔随机分为4组,每组10只,对照组餵普通饲料;模型组:普通饲料加质量分数为1.5%的胆固醇餵养;黄芪多糖组:普通饲料加质量分数为1.5%的胆固醇餵养,同时腹腔注射APS(12.0mg/kg);卡托普利组:普通饲料加质量分数为1.5%的胆固醇餵养,同时灌喂卡托普利(15.0mg/kg);10周后,测定各组空腹血清或血浆三脂酰甘油、总胆固醇、高密度脂蛋白胆固醇、一氧化氮、内皮素-1(ET-1)、丙二醛、C反应蛋白含量以及超氧化物歧化酶活性,并计算主动脉内膜粥样斑块面积。

Microarray technique was applied to look into the gene expression profiles. Ox-LDL induced HAEC apoptosis by inducing many redox- and apoptosis-related genes. Sal B prevented the ox-LDL induced endothelial damage and even induced endothelial cell proliferation.

本计划亦探讨丹参酚酸 B 抑制氧化低密度脂蛋白所造成内皮细胞的损伤与细胞附著分子表现的作用机转,亦引入微矩列技术以探讨基因表现差异之谱型,氧化低密度脂蛋白诱导许多氧化还原与细胞凋亡相关基因,丹参酚酸 B 可保护内皮细胞损伤甚至促进其增生。

The results showed that myristic acid(14∶0) and linoleic acid (18∶2) were significantly increased,and positively correlated with the levels of TC, TG, LDL-C and apoB;while the levels of docosahexaenoic acid (DHA,22∶6),arachidonic acid (20∶4) and docosatetraenoic acid (22∶4) and stearic acid(18∶0) are significantly decreased, and inversely correlated with the levels of TC, TG, LDL-C and apoB in patients with hyperlipemia.

结果表明:患者肉豆蔻酸(14∶0)和亚油酸(18∶2)明显增高,与总胆固醇、甘油三酯、低密度脂蛋白-胆固醇和载脂蛋白B水平呈正相关;而二十二碳六烯酸(DHA,22∶6)、二十碳四烯酸(AA,20∶4)和二十二碳四烯酸(22∶4)以及硬脂酸(18∶0)明显降低,与TC、TG、LDL-C和apoB水平呈负相关。

The results showed that myristic acid(14∶0) and linoleic acid (18∶2) were significantly increased,and positively correlated with the levels of TC, TG, LDLC and apoB;while the levels of docosahexaenoic acid (DHA,22∶6),arachidonic acid (20∶4) and docosatetraenoic acid (22∶4) an...

结果表明:患者肉豆蔻酸(140)和亚油酸(182)明显增高,与总胆固醇、甘油三酯、低密度脂蛋白-胆固醇和载脂蛋白B水平呈正相关;而二十二碳六烯酸(DHA,226)、二十碳四烯酸(AA,204)和二十二碳四烯酸(224)以及硬脂酸(180)明显降低,与TC、TG、LDL-C和apoB水平呈负相关。

Nicotinic acid reduces total cholesterol, LDL and triglycerides at the same time raising HDL.

烟酸降低总胆固醇,低密度脂蛋白和甘油三酯,同时提高高密度脂蛋白

According to the definition of OCSP, patients were classified into the following 4 clinical subgroups:total anterior circulation infarcts, partial anterior circulation infarcts, lacunar infarcts, and posterior circulation infarcts by 1 neurologist.The frequencies were compared between subgroups, In the subgroup of which frequency was hightest, progressive and nonprogressive patients were compared in terms of the following variables:age, gender, hypertension,diabetes mellitus,cigarette smoking, The Canadian Neurological Scale Score at entry, systolic blood pressure at entry,fever at entry(body temperature37°C),stochastic blood glucose at entry, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, fibrinogen, large-artery atherosclerosis (50% stenosis or occlusion of the corresponding artery).

对进展性脑卒中发病率最高的亚型,选取年龄、性别、既往高血压史、糖尿病史、吸烟史、入院时加拿大卒中量表(The Canadian Neurological Scale Score,CNS)评分、入院时收缩压、入院时发热(体温大于37°C)、入院时随机血糖、胆固醇水平、甘油三酯水平、高密度脂蛋白水平、低密度脂蛋白水平、纤维蛋白原水平、相应大动脉粥样硬化(≥50%狭窄或闭塞)共15个可能的危险因素进行评定。

Methods Ninety patients with diabetic nephropathy were randomly divided into two groups: control group and observative group. The routine treatment including administration of diabetic diet, blood glucose control and lossing blood pressure for 8 weeks. Ramipril was performed in control group for 8 weeks. Fasting blood glucose, total cholesterol, triglyceride, serum creatinine, urinary albumin excretion rate and plasma lipoprotein were detected and compared before treatment and 8 weeks later in two group.

90例DN患者随机分为两组,治疗组46例,对照组44例,两组患者均给予糖尿病饮食、控制血糖和降血压等常规治疗,对照组给予雷米普利,观察组在对照组治疗的基础上给予氟伐他汀,两组疗程均为8周;于治疗前和治疗8周后检测两组空腹血糖、总胆固醇、甘油三脂、血肌酐、尿微量白蛋白排泄率和血浆脂蛋白,并进行比较。

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