脂蛋白

DiscussionsHealth threatens of cardiovascular disease to our country people accrete increasingly.

独立保护因素的保护作用由强到弱的顺序高密度脂蛋白，载脂蛋白A水平。

Smoking\ Arteriosclerotic cerebral infarction\ Apolipoprotein\ High density lipoprotein cholesterol

吸烟；动脉硬化性脑梗塞；载脂蛋白；高密度脂蛋白胆固醇

Methods: Serum apolipoproteinB,high density lipoprotein cholesterol and total cholesterol were estimated and analysed in both 102 ASCI patients and 108 control people.

对102例ASCI患者及108例正常人血清载脂蛋白、高密度脂蛋白胆固醇、总胆固醇进行测定及对比分析。

Methods :Serum apolipoprotein-B,high density lipoprotein cholesterol and total cholesterol were estimated and ana-lysed in both 102 ASCI patients and 108 control people.

对102例ASCI患者及108例正常人血清载脂蛋白、高密度脂蛋白胆固醇、总胆固醇进行测定及对比分析。

The results show that firstly, ApoE and LDL receptors can be transported bidirectionally (i.e. retro-and anterogr-adely) in the axoplasm along axons. Secondly, ApoE derived from regenerating fillers can be transported re t rogradely to the cell bodies.

本文用免疫细胞化学法研究正常和再生的大白鼠外周神经中脱辅基脂蛋白E和低密度脂蛋白受体的运输特性，发现在正常的外周神经中，ApoE及LDL受体在轴浆中均可沿轴突正行和逆行运输；再生的神经可产生ApoE，ApoE可逆行向细胞体转运。

High-fat feeding of both strains led to decreased serum triglycerides, hepatic steatosis, and hypercholesterolemia; howeer, B6 mice deeloped worse steatosis and a larger increase in LDL cholesterol. Both B6 background and high-fat feeding increased sterol regulatory element-binding protein-1c (SREBP-1c), a key regulator of lipogenic gene transcription, and its downstream targets.

两种品系的高脂喂养都导致血清甘油三酯降低，脂肪肝，和高胆固醇血症；然而，B6小鼠产生更严重的脂肪肝和低密度脂蛋白胆固醇的增加。B6遗传背景和高脂喂养都增加甾醇调解元件结合蛋白-1c（SREBP-1c），它是脂肪生成基因转录和它的下游靶点的关键调解元件。

Results: After the therapy their high density lipoprotein cholesterol rose significantly(P＜0.05), the low density lipoprotein cholesterol dropped significantly(P＜0.05). Their glycerin trinitrate fat didn't change obviously.

结果：用药后高密度脂蛋白胆固醇明显上升（P.05），低密度脂蛋白胆固醇明显下降（P.05），甘油三脂无明显变化。

However, fully consideration of special structure and physiological function of CRP is critical to investigate whether CRP provide protect effect or pathogenic effect in the progression of atherosclerosis. CRP is a member of pentrxins family, which consists of five identical, noncovalently associated 23-kDa protomers arranged symmetrically around a central pore with a 102 A external diameter. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. The opposite face of the pentamer is the effector face, where complement Clq binds and Fc receptors are presumed to bind. A cleft extends from the center of the protomer to the central pore of the pentamer. Both faces ofpentamer form a special bi-phase structure: one face is the ligand recognition phase, which can recognize apoptosis cells and enzyme modified low density lipoprotein in which PCh is exposed.

CRP是一种五聚体蛋白，外径为102 A，由5个相同的单体以非共价键结合，形成双面的环形结构，每个单体的配体识别位点或受体结合位点分别位于五聚体两个平面上，分别组成配体识别相和效应器相，从而构成特殊的二相性结构：一面为配体识别相，含有磷酸胆碱(phosphorycholine，PCh)结合位点，能够使CRP识别在病理条件下暴露出PCh的凋亡细胞、酶修饰低密度脂蛋白(enzyme modified low density lipoprotein，E-LDL)等。E-LDL是天然低密度脂蛋白(native Low density lipoprotein，N-LDL)在多种蛋白酶，如胰蛋白酶、神经氨酸酶、胆固醇酯酶等作用下的代谢产物，其主要特点是结构发生改变(N-LDL大小均匀，平均直径250±30 A，E-LDL大小差异极大，直径为100-2000 A)，暴露磷酸胆碱位点，能够被CRP识别；另一面为效应器相，能够与巨噬细胞、单核细胞表面受体FcγRⅡa结合，介导巨噬细胞、单核细胞识别及吞噬凋亡、坏死细胞作用。

We investigated the effect of the known hypocholesterolaemic and anti-atherosclerotic drug probucol on serum lipids, lipoproteins and atherosclerosis in fat-fed low density lipoprotein receptor deficient mice.

本实验研究了抗高胆固醇血症和抗动脉粥样硬化药物普罗布考对脂肪饲养低密度脂蛋白受体缺失小鼠的血清脂质，脂蛋白和动脉粥样硬化的影响。

The height, weight, blood pressure, fasting plasms glucose, fasting serum insulin, glycosylated hemoglobin (HbA1c), triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and serum nitric oxide were measured before and after the therapy. The body mass index and homeostasis model assessment-insulin resistant index were calculated. The flow-mediated dilatation and endothelium independent dilatation were measured by high-resolution ultrasound.

治疗前后均检测身高、体质量、血压、空腹血糖、血浆胰岛素、糖化血红蛋白(HbA1c)、甘油三脂、胆固醇、低密度脂蛋白、高密度脂蛋白数(homeostasis model assessment-insulin resistant index， HOMA-IR)，并用高分辨超声技术检测肱动脉血流介导的内皮依赖性舒张(flow-mediated dilatation， FMD)和硝酸甘油介导的非内皮依赖性舒张(endothelium independent dilatation， EID)。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。