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Apolipoprotein D is a member of the lipocalin family. ApoD can bind small hydrophobic molecules such as cholesterol and arachidonic acid, etc. It also plays a role in many physiological and pathological processes such as development and differertiation of embryo, apoptosis of cancer cells, immune defense, and so on.

脂蛋白D属于脂蛋白家族,和该家族的其它成员一样,其基本功能是转运一些脂类的小分子物质,还参与胚胎的发育、分化;肿瘤细胞的发生、发展和凋亡;免疫性反应;抵抗外界环境胁迫以及神经系统的发生和损伤修复。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降,而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高;但是,OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异;⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明:①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异,并以肝组织中的差异氨基酸数量为最多,包括各种生酮和生糖氨基酸水平在OP组的升高,说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一;②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸,说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异;③长期高脂饮食喂养后,动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异,这些菌群上的差别可能在动物体重增长的调节上产生影响;④与OR动物相比,OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Objective To study the relation of apoliprotein E and lipoprotein lipase gene polymorphisms with CHD.

目的:研究载脂蛋白E基因和脂蛋白脂酶基因多态性与冠心病的关系。

Prehypertensive subjects versus normotensive subjects had significantly higher body mass index and subscapular skinfold, systolic and diastolic blood pressures, and triglycerides beginning in childhood; higher glucose in adolescence; and higher low-density lipoprotein cholesterol, fasting insulin, and insulin resistance index in adulthood. Hypertensive subjects versus normotensive subjects had higher adiposity measures, SBP and DBP, glucose, and triglycerides beginning in childhood; higher insulin and insulin resistant index in childhood and adulthood; and lower high-density lipoprotein, cholesterol in adulthood.

与正常血压者相比,高血压前期者其幼年期基础体重指数、肩胛下皮肤皱褶厚度、收缩压和舒张压、甘油三脂等指标更高;在青春期血糖水平更高;在成年期低密度脂蛋白胆固醇、空腹胰岛素、胰岛素抵抗指数更高;与正常血压者相比,高血压者在幼年时基础水平的肥胖积分、SBP 和DBP、血糖、甘油三脂等更高;在幼年期和成年期胰岛素和胰岛素抵抗指数水平均更高;在成年期高密度脂蛋白胆固醇水平更低。

The changes of the level of TCH,TG,HDL and LDL in 2 groups were observed.

观察两组治疗前后总胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白的变化。

Aim To understand the features of lipoprotein lipase and its role in the distinctive lipid metabolism in tree shrew, which is considered to be an animal protected from atherosclerosis.

目的 了解不易感动脉粥样硬化动物树鼩的脂蛋白脂肪酶的结构和活性特点,并与其它种属比较,探讨脂蛋白脂肪酶在树鼩独特脂代谢中的作用。

The results showed that either of the extracted propolis had significant inhibitory effect on the level of triglyceride, total cholesterol, LDL-C,GPT and GOT in serum, and TC, TG and MDA in liver, but were ineffective on HDL-C, MDA, SOD and NO levels in serum. Ethanol extracted propolis also reduced the body weight, liver weight and liver index of hyperlipidemic SD rats, while water extracted propolis were adiaphorous.

结果表明:蜂胶醇提液和水提液均能有效抑制高脂血症SD大鼠血清中的甘油三酯、总胆固醇、低密度脂蛋白、谷丙转氨酶、谷草转氨酶的升高,并且能有效抑制肝脏组织中的TC、TG、MDA的升高,但对血清中的高密度脂蛋白、超氧化物歧化酶、丙二醛、一氧化氮的影响不明显;蜂胶醇提液能有效降低高脂血症SD大鼠的体重、肝重及肝指数,蜂胶水提液对体重、肝重及肝指数的影响则不显著。

Results Fetal Macrosomia group: the rate of obesity is 9.4%, obviously higher than that of the contrast group, 2.03%(χ2=7.4715,P.01), the rate of overweight is 19.4%, higher than that of the contrast group, 3.3%(χ2=18.9434,P.01);Fetal Macrosomia group: there is a remarkable difference in GLU, ALT, HDL, Insulin, and APN,(P﹤0.05~0.01),There were marked differences in the aspects of body mass index, the level of blood grease,HDL, ALT, HOMA-IR, adiponectin(P.05~0.01) Conclusion: In adolescence of Fetal Macrosomia weight index, GLU, Insulin and ALT are obviously higher than that of the contrast group; the HDL ,and APN which has great protective effect to angiosclerosis is also absolutely lower than the compare group.

结果:巨大儿组:肥胖率为9.4%,明显高于对照组2.03%(χ2=7.4715,P.01)、超重率为19.4%,高于对照组的3.3%(χ2=18.9434,P﹤0.01);巨大儿组:血糖、转氨酶、高密度脂蛋白、胰岛素、脂联素方面有显著差异,(P﹤0.05~0.01),结论:巨大儿在青少年期,其体重指数、血糖、胰岛素、转氨酶水平明显高于对照组,对动脉硬化有保护作用的高密度脂蛋白、脂联素明显低于对照组。

Aim To investigate the possible interaction of cholesteryl ester transfer protein level with the lipid transport between the lipoproteins.

目的分析不同高脂血症人群血清胆固醇酯转运蛋白水平及其对血浆各脂蛋白间脂质转运的调节作用。

METHODS: Seralbumin, serum creatine, blood sugar, total cholesterol, total triacylglycerol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were detected after more than 12 hours of fasting.

测定过夜空腹12 h以上血白蛋白、血肌酐、血糖、总胆固醇、总三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇;用放射免疫法测定早晨第1次尿中白蛋白。

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