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脂蛋白

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Methods: Divide 196 cases into 3 groups by their blood pressure and cardiograph measure result. 62 cases in high blood pressure group, 45 cases in cardiovascular disease group, 89 cases in control group. HS-CRP and ABLU were measured by BN-Prospec Analysis System. GLU, TC. TG, HDL-C, LDL-C were measured by OLYMPUS 2700 Automatic biochemical analyzer.

对1%例70岁以上老年人通过血压和心电图结果分为三组,其中高血压62例;冠心病45例;对照组89例,空腹采血,留取晨尿,分别用BN-Prospec特种蛋白分析仪,测定尿微量白蛋白及超敏C反应蛋白,用OLYMPUS2700全自动生化分析仪测定空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇。

Adult male SD rats were randomly divided into five groups:control group、hypercholesterolemia control group、dosage group with 72.3%,80.5%,96.1% deacetylated flyblow chitosan.The rats were fed with a high cholesterol diet and were administrated flyblow chitosan continuously for 8 weeks at the same time,then the blood lipid and weight were measured.

取成年雄性SD大鼠随机分为5组,分别为正常对照组、高脂模型组、蝇蛆壳聚糖72.3%,80.5%,96.1%脱乙酰度组,给高脂饲料造模的同时连续给予蝇蛆壳聚糖8周,测定大鼠血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白含量,同时观察对大鼠体重影响。

Background— Numerous in itro studies suggest that sphingosine 1-phosphate (S1P), a bioactie lysosphingolipid associated with high-density lipoproteins, accounts at least partly for the potent antiinflammatory properties of high-density lipoprotein and, thereby, contributes to the antiatherogenic potential attributed to high-density lipoproteins.

背景——众多的活体研究表明鞘氨醇1-磷酸盐作为一种与高密度脂蛋白相关的生物活性溶血磷脂,至少是高密度脂蛋白有力抗炎特质的部分原因,从而促成高密度脂蛋白的抗动脉粥样硬化潜能。

The apoB gene polymorphism on Xba I site of 53 6 unrelated Chinese Han people,aged 25~64 years,was analyzed using PCR and Re striction Fragment Length Polymorphismmethod;serum apoA I,apoB,total chole s terol,triglyceride,HDL cholesterolwere measured,and LDL choleste roland non-HDL cholesterolwere calculated.

采用聚 合酶链反应结合限制性片段长度多态性分析的方法,分析536名25~64岁的无血缘关系的汉族人的apoB基因Xba I位点多态性,并测定其血清apoA I、apoB、总胆固醇、甘油三酯、高密度脂蛋白胆固醇,并计算低密度脂蛋白胆固醇LDL-C)及非高密度脂蛋白胆固醇。

In addition to, we also found that the treatment of fluvastatin significantly decreased the level of serum CHOL, TG, LDL, and VLDL, only 45.8%, 58%, 64%, and 56% to the untreated group respectively; Whereas, the level of serum HDL and HDL/CHOL were increased by 16.7 % and 153.6% to the untreated group respectively.

另外我们还发现氟伐他汀治疗显著降低髂动脉损伤后血清总胆固醇、甘油三酯、低密度脂蛋白和极低密度脂蛋白的水平,分别为未治疗组的45.8%、58%、64%及56%;而高密度脂蛋白和HDL/CHOL水平,治疗组则较对照组高14.3%及153.6%。

Retrospectivly analyse the coronary heart disease, 68 patients diagnosed the coronary angiography, including Unstable Angina the 24 patients, Stable Angina 32 patients, myocardial infarction 12 patients; Compares the change of normal comparison group 35 patients fasting blood lipide:Trighycerides, Total Cholesterol, High Density Lipoprotein Cholesterol, Low Density Lipoprotein Cholesterol, Apolipoproteins (ApoA1 and ApoB), Fasting Blood Glucose, Fasting Insulin, Insulin area under curve and Glucose area under curve.

回顾性分析经冠状动脉造影确诊的冠心病患者68例,其中包括不稳定型心绞痛患者24例,稳定型心绞痛32例,心肌梗塞12例;正常对照组35例的空腹血脂(血清甘油三酯TG、血总胆固醇TC、高密度脂蛋白胆固醇HDL-C、低密度脂蛋白胆固醇LDL-C、载脂蛋白ApoA1及ApoB)、空腹血糖、空腹胰岛素、糖负荷后胰岛素曲线下面积及葡萄糖曲线下面积的变化并进行比较。

OR>1 indicates dangerous factor, OR<1 protective factor, and OR=1 no significance. The results showed that if triglyceride and very low density lipoprotein cholesterol increased an average level of normal respectively, and there would be OR of TG 2.43 (P<0.05) and OR of VLDL-C 6.09 (P<0.05), the high levels of TG and VLDL-C were the factors of lithogenesis. High density lipoprotein cholesterols (HDL1-C, HDL2-C, HDL3-C), with OR less than one, were the factors of protecting against the formation of gallstone.

结果:甘油三酯和极低密度脂蛋白胆固醇每增加一个正常均值水平,OR值分别是2.43(P<0.05)和6.09(P<0.05),是重要的致石因素指标;高密度脂蛋白胆固醇(HDL1-C、HDL2-C、HDL3-C),OR值均低于1,是重要的防石因素指标;低密度脂蛋白胆固醇和总胆固醇的OR值均小于1,本研究结果提示其可能是一种代谢状态而非保护因素。

The type 2 diabetes-mellitus (T2DM) subjects had higher HOMR-IR, FINS, FPG, TC, TG, LDL and lower ISI than NC subjects. The 2DM subjects with genotype Thr54 (Thr54 homozygotes and heterozygotes) had higher FPG、FINS、HOMR-IR、TG、LDL(P.01) and lower ISI (P.01) than those with genotype Thr (Ala54 homozygotes). Conclusions: The polymorphy of FABP2 has been identified in the Han nationality in Bengbu.

与NC组比较,T2DM组的胰岛素抵抗指数、胰岛素均明显增高(P.01),胰岛素敏感指数显著降低(P.01);甘油三酯、总胆固醇、低密度脂蛋白均明显增高(P.01),高密度脂蛋白明显降低(P.01)。T2DM组中,FABP2Ala54Ala与Ala54Thr及Thr54Thr基因型患者比较,后两者的空腹胰岛素、HOMA-IR指数、空腹血糖、甘油三酯水平、低密度脂蛋白明显增高(P.01),而胰岛素敏感指数显著降低(P.01)。

The drop in apolipoprotein II in the long walkers was matched by a rise in the blood level of apolipoprotein I, a "good" fat that is associated with unclogged arteries.

长距离步行者载脂蛋白II的下降部分与血液中载脂蛋白I的上升部分相当,载脂蛋白I是一种与动脉疏通有关的&有益&的脂肪。

However,aortie fatty streaks were strongly related to ante一mortem levels of both total and low一density liPopro一tein eholesterol(:=0.67,p.0001 for eaeh assoei一ation),independently of raee,sex,and age,andwere inversely eorrel...

但主动脉脂肪条纹与死前总胆固醇及低密度脂蛋白胆固醇水平密切相关r=0.67,P(0.000一,二者同,与种族、性别、年龄无关,而与高密度脂蛋白胆固醇对低密度及极低密度脂蛋白胆固醇之比成负相关r二一。

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