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脂蛋白

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Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study.

氧化低密度脂蛋白、他汀类药物治疗、定量冠脉造影和粥样斑块体积之间的联系:强降脂引起斑块消退的研究。

Results: There have highly significant between treatment and control in relieving angina pectoris attacks, improv- ing syndrome of thoracic obstruction cardialgia, improving electrocardiogram effective power , time limit of syndrome drug action and lasting time limit difference.

结果:两组在缓解心绞痛发作、改善胸痹心痛证候、改善心电图及有效率方面比较,差异有非常显著意义(P〈0.05或P〈0.01);两组间的证候药效起效时限与持续时限差异均有非常显著意义(P〈0.01);治疗后治疗组的总胆固醇、甘油三脂、高密度脂蛋白胆固醇较治疗前均有明显改善(P〈0.05或P〈0.01)。

Acupuncutre ; Lowering Fat and Losing Weight Tea ; Pure Corpulence ; High Fat Blood Disease Cure

单纯性肥胖;高脂蛋白血症;针刺;降脂减肥茶

Blood lipid,blood viscosity,coagulation-time,platelet agglutination rate,lipid hyperoxide and carry-lipoprotein level were determined using Transansio automatic biochemical analyzer,automatic rinse spin rheometer and Chrono-log 400 platelet agglutinating meter respectively.

采用Transansio全自动生化分析仪、自动冲洗旋转式血液流变仪及Chrono-log400血小板聚集仪分别测定各试验组动物血脂、血粘度、凝血时间、血小板聚集率脂质过氧化物及载脂蛋白水平的作用。

The experiment two: enzyme preparation significantly improved average daily gainand feed conversion ratio (P<0.05). Enzyme preparation significantly increased energymetabolizability and digestibility of crude fiber, crude protein and neutral detergent fiber,but had no remarkable effect on digestibility of dry matter, crude fat and acid detergentfiber. Enzyme preparation significantly decreased the relative viscosity of duodenal andjejunal digesta. The pH of intestine had no noticed difference in all groups. Enzymepreparation significantly decreased relative weight of gizzard, proventficulus, duodenum,jejunum and ileum. Enzyme preparation significantly increased villus size of duodenumand jejunum, and villus to crypt ratio of duodenum and ileum significantly increased too.Enzyme preparation considerably decreased ileal crypt height (P<0.05), and didn"t affectthickness of intestinal wall. Supplementing enzyme preparation, the serum glucose, totalprotein and alanine aminotransferase, but enzyme preparation hadn"t noticed influenceupon uric acid, total cholesterol, triglyceride and high-density lipoproteins. Enzymepreparation significantly increased insulin, triiodothyronine and insulin-like growthfactor-Ⅰ. Adding enzyme preparation, the percentage of thyroid stimulating hormone andgrowth hormone in the serum increased 16.44%, 19.18% and 18.84%, 21.74%respectively, and the percentage of glucagon and thyroxine decreased 12.07%, 14.36% and 13.79%, 15.40%, but failed to reach statistical significance (P>0.05). Enzymepreparation significantly increased (P<0.05) the trypsin and amylase activity of duodenaland jejunal digesta, but enzyme preparation didnt affect significantly (P>0.05) theintestinal lipase activity and pancreatic digestive enzyme. Enzyme preparation had nosignificant effect on caecal microbial population.

试验二:酶制剂显著提高平均日增重和饲料转化率(P<0.05);酶制剂显著提高能量代谢率及粗纤维、粗蛋白、中性洗涤纤维消化率(P<0.05),而对干物质、粗脂肪、酸性洗涤纤维消化率影响不显著;酶制剂显著降低十二指肠和空肠食糜相对粘度(P<0.05);添加酶制剂对肠道pH影响不显著;酶制剂显著降低肌胃、腺胃、十二指肠、空肠、回肠相对重(P<0.05),显著提高十二指肠和空肠绒毛高度,显著增加十二指肠和回肠绒毛高度/隐窝深度,降低回肠隐窝深度(P<0.05),对肠壁厚度影响不显著;酶制剂显著提高血清葡萄糖、总蛋白和谷丙转氨酶浓度(P<0.05),对尿酸、总胆固醇、甘油三酯及高密度脂蛋白浓度影响不显著,显著提高胰岛素、T_3、IGF-Ⅰ水平,添加酶制剂后,促甲状腺激素、生长激素分别提高16.44%、19.18%和18.84%、21.74%,胰高血糖素和T_4分别降低12.07%、14.36%和13.79%、15.40%,但差异不显著;酶制剂对胰腺消化酶活性影响不显著,显著增加十二指肠和空肠胰蛋白酶、淀粉酶活性,对小肠脂肪酶活性影响不显著;酶制剂对盲肠微生物菌落数影响不显著。

METHED We selected 40 patients underwent coronary angiography. Blood samples for measurement of CRP, Cardiac Troponin I, Creatine Kinase, MB isoenzyme of CK and lipoidemia were taken in the morning just before angiography in all patients. Each subject was sought details of sex, age. Body Mass Index, history of smoking, hypertension, diabetes mellitus.

方法选取住院并接受冠状动脉造影(coronary angiography, CAG)的患者40名进入本研究,均于CAG前采集空腹血,检验C反应蛋白、肌钙蛋白Ⅰ(Troponin Ⅰ,TnⅠ)、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、肌酸激酶、肌酸激酶同工酶MB,并收集所有患者年龄、年龄、高血压史、糖尿病史、吸烟史、体重指数的资料。

Results: 11 three dose of Kangzhitang has obviously reduced the concents of blood TC, TG, LDL-C, VLDL-C, apoB, LP , oxLDL, MDA and the ratio of TC/HDL-C of hyperlipidemia in rats: it has obviously raisen the concents of blood HDL-C, apoA-1 and the activity of SOD: it has obviously raisen the low density lipoprotein recepter mRNA , and been better than model group: the middle dose group is the most advantage.

结果:康脂汤高中低三个剂量均能显著降低实验性高脂血症大鼠血中的TC、TG、LDL-C、VLDL-C、apoB、LP、ox-LDL、MDA,显著升高血中HDL-C、apoAI水平及SOD活性,中剂量效果最好。治疗组大鼠低密度脂蛋白受体基因表达水平比模型组明显提高。

Compared with these of fat-fed group,the body weight,blood glucose levels after oral glucose and the glucose area under curve,40min and 90min blood glucose levels after insulin injection subcutaneously and the glucose area under curve in the insulin tolerance test,the fasting serum insulin,insulin resistance index,serum cholesterol,triglyceride and lower density lipoprotein cholesterol decreased.

n-6脂肪酸组从第1~10周体重均较高脂组明显减轻,糖负荷后血糖和糖耐量试验中葡萄糖曲线下面积、皮下注射胰岛素后40 min9、0 min血糖及胰岛素耐量试验中葡萄糖曲线下面积、血清胰岛素、胰岛素抵抗指数、血清胆固醇、甘油三酯和低密度脂蛋白含量均较高脂组明显降低

The results indicated that the paralysors and excitomotors of calcium channel changed the expression level of lipoprotein lipase, peroxisome proliferators-activated receptor gamma, fatty acid synthetase, and the lipid accumulation, markedly.

结果表明:钙通道阻滞剂和激动剂显著改变了脂蛋白脂酶,过氧化物增殖激活受体γ、脂肪酸合成酶的表达水平,且影响细胞内的脂质蓄积。

Biotechnology Research Institute is primarily dedicated to education and research in biotechnology including molecular bio-pharming, subviral RNA pathogens, the metabolism of lipids and lipoproteins, functions and immune suppression, cell division and DNA replication, membrane lipids, antioxidants, molecular-genetic analysis of RNA viruses, blood coagulation.

主要致力于生物技术的教学与研究,研究领域包括分子生物药物化学,亚病毒RNA病原体,脂类和脂蛋白的物质代谢,机能和免疫抑制,细胞分裂和DNA复制,膜脂,抗氧化剂,RNA病毒的分子-遗传分析,血凝固等。

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