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脂肪变性

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The differing prevalence of hepatic steatosis between these groups was associated with similar differences in visceral adiposity.

不同组别之间,肝脏脂肪变性盛行率的差异与脏器脂肪差异相仿。

The pathologic changes were observed by light and electron microscope.Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性,并可见肝细胞坏死灶,姜黄素治疗组的肝细胞未见坏死改变,水样变性和脂肪变性程度减轻,以高剂量姜黄素组的治疗效果最为明显。

Results The liver tissues of the rats in model group showed obvious hydropic and fatty degeneration.And the necrosis foci of hepatocytes were seen in liver tissue.Hepatocytes in curcumine treatment group showed no necrotic changes,and the degree of hydropic and fatty degeneration was markedly reduced,especially in the high-dose curcumine treatment group.

结果 模型组大鼠的肝组织呈现明显的水样变性和脂肪变性,并可见肝细胞坏死灶,姜黄素治疗组的肝细胞未见坏死改变,水样变性和脂肪变性程度减轻,以高剂量姜黄素组的治疗效果最为明显。

In medium and high energy groups, histological cholestasis presented characterized by bile plugs in bile ducts, proliferation of interlobular bile ducts, bile pigments in Kupffer cells and hepatocytes, and above performances were more severe in high energy group. In medium energy group, there was only mild liver steatosis, whereas there was significant steatosis in high energy TPN group, and fat accumulation was periportal in distribution.

中能量和高能量TPN组肝组织出现胆栓形成、小叶间胆管增生、肝细胞和枯否氏细胞内胆色素沉积等淤胆特征,而以高能量组较严重,在中能量组仅出现轻度肝脂肪变性,而高能量组出现明显肝脂肪变性,脂肪沉积主要分布于门静脉周围区。

The pathological observation indicated that the hydrogenic degeneration, steaosis and lymphoid cell infiltration appeared in liver, instead of other organ or other tissues.

组织病理学检查显示转基因小鼠的肝细胞出现水样变性、脂肪变性及淋巴细胞浸润等轻度炎性反应,这些变化不随年龄增长而加重;其他组织的病理学检查无异常。

It was suggested that the pharmacodynamics and therapeutic function of Qizhi complex prescription to fatty liver were: 1. Adjust lipometabolism: reducing TC and TG; 2. Decreasing fatty degeneration of liver cell; 3. Promoting the convalescence of hepatocellular function; 4. Anti-lipid peroxide: increasing the activation of peroxidase, decreasing the content of products of lipid peroxide. 5. Restraining Kupffer cell function of fatty liver rat; 6. Improving fluidity of hepatocellular microsome and mitochondria.

芪枳合剂治疗脂肪肝的效应及药效学机制为: 1、调整脂质代谢:降低血清甘油三脂和胆固醇; 2、减轻肝细胞脂肪变性; 3、促进肝细胞功能恢复,有效治疗脂肪性肝炎; 4、抗脂质过氧化:提高抗氧化酶活性、降低脂质过氧化产物含量; 5、抑制脂肪肝大鼠Kupffer细胞功能; 6、改善肝细胞微粒体、线粒体膜流动性。

Affect on the liver pathological state after XIEZHIPING treated: the golden hamster hepatic tissue morphous structure of normal control was normal, which had regular hepatic lobules and no lipid droplet;that of model control manifested diffuse heavy adipose degeneration and heavy ballooning degeneration with inflammatory cell infiltrate which mainly composed of lympholeukocyte;that of high dose group showed midrange ballooning degeneration with chronic inflammatory cell infiltrate which mainly composed of lympholeukocyte and plasmocyte;that of media dose group indicated slight focus ballooning degeneration with a small quantity normal hepatic cells in some locals;that of low dose group appeared midrange adipose degeneration with a few lympholeukocyte cell infiltrate in the parts of central veins and port area.

泻脂平治疗后对肝脏病理状况的影响:空白对照组金黄地鼠的肝组织形态结构正常,肝小叶规则,无脂滴发现;模型对照组肝脏弥漫性重度脂肪变性,发生重度气球样变,伴见以淋巴细胞为主的慢性炎性细胞浸润;泻脂平高剂量组肝细胞呈现中度气球样变,伴见以淋巴细胞、浆细胞为主的慢性炎性细胞浸润;中剂量组肝细胞轻度灶性气球样变,局部可见少量正常肝细胞;低剂量组肝细胞呈中度脂肪变性,可见中央静脉及汇管区些许淋巴细胞浸润。

Affect on the liver pathological state afterXIEZHIPING treated: the golden hamster hepatic tissue morphous structureof normal control was normal, which had regular hepatic lobules and nolipid droplet: that of model control manifested diffuse heavy adiposedegeneration and heavy ballooning degeneration with inflammatory cell infiltrate which mainly composed of lympholeukocyte; that of high dosegroup showed midrange ballooning degeneration with chronic inflammatorycell infiltrate which mainly composed of lympholeukocyte and plasmocyte;that of media dose group indicated slight focus ballooning degenerationwith a small quantity normal hepatic cells in some locals; that of lowdose group appeared midrange adipose degeneration with a fewlympholeukocyte cell infiltrate in the parts of central veins and portarea.

泻脂平治疗后对肝脏病理状况的影响:空白对照组金黄地鼠的肝组织形态结构正常,肝小叶规则,无脂滴发现;模型对照组肝脏弥漫性重度脂肪变性,发生重度气球样变,伴见以淋巴细胞为主的慢性炎性细胞浸润;泻脂平高剂量组肝细胞呈现中度气球样变,伴见以淋巴细胞、浆细胞为主的慢性炎性细胞浸润;中剂量组肝细胞轻度灶性气球样变,局部可见少量正常肝细胞;低剂量组肝细胞呈中度脂肪变性,可见中央静脉及汇管区些许淋巴细胞浸润。

Sinusoid from the fifth week of expansion, swelling and degeneration of liver cells has varying degrees of fatty degeneration, infiltration of inflammatory cells at the same time.

从第5周起肝窦扩张,肝细胞变性肿胀并有不同程度的脂肪变性,同时出现炎症细胞浸润。

Different degrees of hepatic fatty degeneration was observed in group C ( H = 13.36, P = 0.0003), but not in group A and B.

脂肪变性程度为+~+++( H = 13.36, P = 0.0003),正常组和常规组大鼠肝细胞内未见明显脂肪变性

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