脂肪代谢的

PURPOSE : Pass studying type 2 diabetes chinese medical science' pattern of syndrome together with relation of metabolic disorder and hepatica ,providing leading effect for chian and west medcine to cure diabetes afterward.

目的：观察2型糖尿病中医证型与脂代谢紊乱、并发脂肪肝的关系。为中西医结合防治2型糖尿病脂代谢紊乱和并发脂肪肝提供理论和临床依据。

This heterogeneous phenotype (insulin resistance with respect to glucose metabolism and insulin sensitivity with respect to lipogenesis) seems to be a typical behavior of the liver able to explain simultaneously all the metabolic features of the insulin resistance syndrome.

肝脏的这种异质性表型(与葡萄糖代谢有关的胰岛素抵抗状态及与脂肪合成有关的胰岛素敏感状态)可能是胰岛素抵抗综合征所有代谢异常特点(葡萄糖代谢异常和脂肪代谢异常)的一种合理解释。

Experimental research indicates:QZZGX granule can treat alcoholic fatty liver and DL桬thionine aminoacid fatty liver of the mouse by adjusting metabolism of fat, descending the level of TG,Gn in the liver, improving liver function, anti梠xidat ion descending the content of oxyproling hydroxyproling and improving the level of NO in the body.

实验研究表明：该药对酒精性和乙硫氨酸脂肪肝大鼠通过调节脂肪代谢、降低肝内TG、Gn水平、对酒精性脂肪肝大鼠改善肝功能、抗氧化、降低羟脯氨酸含量和改善体内一氧化氮水平等途径达到治疗脂肪肝的目的。

After finish the digestion, then flow back to the blood.also, during the period of liver and gallbladder concertrate in the hepatoenteral circulation,the bile acid can drain massively with the excrement.and more seriously after adding the fat feed stuff.if this condition go on, the fat cannot be absorbed in time and the energy will be wasted and cause some disease and etc.but after adding the appropriate exogenetic emulsifier,the question can be solved.

作为正常的机体，胆汁酸由肝脏分泌，进入肠道，在完成消化，回流入血液，又在肝脏和胆囊重新富集的肝肠循环的过程中，会经过粪便大量流失。在脂肪含量较高的饲料配方下，流失更为严重。日肝脏分泌量不足弥补流失量，会造成脂肪消化的阻滞，能量的浪费，且易诱发肝胆代谢紊乱等各种疾病。得不到消化吸收的油脂，在肠道内被噬油微生物降解，使噬油微生物类群大量增殖，打破原来肠道内微生态平衡，产生腹泻等菌群失调症，以上的问题，都是由于脂肪乳化作用不足和脂肪代谢失调造成的。在补充了合适本物种须求的外源性乳化剂后，问题可得到解决。

Fibroblast growth factor 21（FGF21）is a novel fatty metabolic regulator. FGF21 mRNA is most abundantly expressed in liver. FGF21 contribute to fat metabolism, as well as ketogenic responses in liver,and it can promote the uptake of glucose, promote insulin secretion, delaying the development of tumors and other function.

成纤维细胞生长因子21（fibroblast growth factor 21，FGF21）是一种主要的脂肪代谢调节因子，主要在肝脏中表达；FGF21有助于肝脏的脂肪代谢以及生酮反应，可以促进脂肪细胞摄取葡萄糖，促进胰岛素分泌，延缓肿瘤的发展等功能。

The effects of total triterpenes of Lagerstroemia specious L on adipocyte's glucose and fat metabolism were compared, for assessing the possible mechanism of its hypoglycemic activity.

为探讨大叶紫薇中总三萜对3T3-L1细胞葡萄糖和脂肪代谢的影响，探讨大叶紫薇中总三萜可能的降血糖作用机制。

The conclusion indicated that pyruvate supplement could accelerate the speed of body energy metabolism and slower weight and body fat gain during exercises. Due to the influences of pyruvate supplement on the levels of enemies and hormones to adjust body lipometabolism during exercises, body blood lipid and glucose levels decreased, and the process of fat metabolism came under.

丙酮酸补充可在一定程度上减慢运动机体体重和体脂的增长速度，加快运动机体能量代谢速度；并通过影响运动机体脂肪代谢相关调控酶和激素水平，使其血脂和血糖水平下降，从而影响其脂肪代谢过程。

It was suggested that the pharmacodynamics and therapeutic function of Qizhi complex prescription to fatty liver were: 1. Adjust lipometabolism: reducing TC and TG; 2. Decreasing fatty degeneration of liver cell; 3. Promoting the convalescence of hepatocellular function; 4. Anti-lipid peroxide: increasing the activation of peroxidase, decreasing the content of products of lipid peroxide. 5. Restraining Kupffer cell function of fatty liver rat; 6. Improving fluidity of hepatocellular microsome and mitochondria.

芪枳合剂治疗脂肪肝的效应及药效学机制为： 1、调整脂质代谢：降低血清甘油三脂和胆固醇； 2、减轻肝细胞脂肪变性； 3、促进肝细胞功能恢复，有效治疗脂肪性肝炎； 4、抗脂质过氧化：提高抗氧化酶活性、降低脂质过氧化产物含量； 5、抑制脂肪肝大鼠Kupffer细胞功能； 6、改善肝细胞微粒体、线粒体膜流动性。

Result First change happened in the marrow,then bone trabeculae and cartilage.A mass of lipid droplet wa...

脂肪代谢的失调是激素性股骨头缺血坏死的主要原因，其变化涉及骨髓、骨小梁及软骨。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失