脂肪代谢

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

PURPOSE : Pass studying type 2 diabetes chinese medical science' pattern of syndrome together with relation of metabolic disorder and hepatica ,providing leading effect for chian and west medcine to cure diabetes afterward.

目的：观察2型糖尿病中医证型与脂代谢紊乱、并发脂肪肝的关系。为中西医结合防治2型糖尿病脂代谢紊乱和并发脂肪肝提供理论和临床依据。

The comparative transcript profiles between OP and OR rats reveal some differentially expressed genes involved in lipids metabolism, ketone body production, blood pressure regulation and adipoctyes differentiation processes.The combined strategy of metabonomics and transcriptomics provides comprehensive information of metabolic characters of obesity and corresponding mechanisms to obese-related metabolic disorders from a systematic view, e.g.

高脂饮食喂养建立的OP大鼠体内的整体代谢特征与OR大鼠不同，具体包括：交感神经系统活性、能量代谢、脂肪酸代谢、氨基酸代谢以及肠道菌群结构等；OP和OR两种表型的转录组学比较也揭示了部分参与脂质代谢、酮体生成、血压调节和脂肪细胞分化等调控过程的基因存在差异性表达。

Results:The etiologic mechanism of steroid-induced necrosis of femoral head is:Disorder of lipometabolism;increasing of intraosseous pressure;Osteoporosis and poisonous action;vasculitis,coagulation before steroid administration and intrava...

结果 ：激素性股骨头缺血坏死存在如下发病机理：脂肪代谢紊乱；骨内压增加；骨质疏松及激素的毒性作用；血管炎、前凝血状况及血管内凝血。

Results:The etiologic mechanism of steroid-induced necrosis of femoral head is:Disorder of lipometabolism;increasing of intraosseous pressure;Osteoporosis and poisonous action;vasculitis,coagulation before steroid administration and intravascular coagulation.

结果：激素性股骨头缺血坏死存在如下发病机理：脂肪代谢紊乱；骨内压增加；骨质疏松及激素的毒性作用；血管炎、前凝血状况及血管内凝血。

Grace Slim-cellulose capsule Breakthrough tradition thin body concept, Creates the thin body new times,Grace Slim-cellulose capsule Take the traditional keeping in good health idea as the basis, Union modern science metabolism balanced theory, Selects: Aloe distill, Spore farina, Spirulina powder, Vitamin, Chitin, The pure medicine food homology plant fine becomes, It includes the many kinds of amino acids, Vitamin, Meals cellulose, Human body essential trace element, Through slows down the fat synthesis, Balanced nutrition metabolism, Acceleration Steatolysis, Continues moderately to reduce the fat

雅姿丹塑形纤维素突破传统瘦身概念，创造瘦身新时代，雅姿丹塑形纤维素以传统养生理念为依据，结合现代科学的代谢平衡理论，选用芦荟提取物，灵芝孢子粉，螺旋藻，维生素，甲壳等纯正药食同源植物精致而成，。它含有多种氨基酸，，维生素，膳食纤维素及人体必需的微量元素，通过减缓脂肪合成，平衡营养代谢，加速脂肪分解，持续适度地减少脂肪。

Result First change happened in the marrow,then bone trabeculae and cartilage.A mass of lipid droplet wa...

脂肪代谢的失调是激素性股骨头缺血坏死的主要原因，其变化涉及骨髓、骨小梁及软骨。

Although LSD training will increase fat metabolism and endurance, it will limit your endurance at marathon paces.

虽然 LSD 式训练法提高脂肪代谢和耐力，但也会限制你的耐力在马拉松的配速。

FOXC2 affects adipocyte metabolism by increasing the sensitivity of the β-adrenergic-cAMP-protein kinase A signaling pathway through alteration of adipocyte PKA holoenzyme composition.

FOXC2通过对各种参与代谢重要基因的调控和提高β-肾上腺素能－cAMP-蛋白激酶A信号通路的敏感性，改变脂肪细胞PKA全酶的组成来影响脂肪细胞的代谢。

The animal model of this method system have, the characteristics of the high fat, high leptin, high Ins, and match with the characteristic of clinical and the pathologic of simple obesity. This studies showed: The acupuncture can obviously reduce the vaule of intaking food and water of the fat rats, and lower the body weight and fat; The acupuncture can urge the diameter, area, physical volume of white fat cell contract, Brown fat tissue of fat rat group surroundings vascular containing large quantity of white fat cell, the acupuncture group was less. this showed: The acupuncture enhanced the white fat cell metabolism, and promotesed the white fat cell to convert to brown fat cell; The frequency of spontaneous electric of nerve cell of pvn of the fat rat is high, the acupuncture counld depress the spontaneous electric of nerve cell of pvn, This showed: the acupuncture can depress the appetite passing to adjust function of pvn nerve; The monoaminergic neurotransmitter of inside of the fat rat brain is disfunction, the acupuncture can rectify this disfunction, and adjust level of 5-HT, and affect appetite, and improve metabolism; The level of leptin and Ins of fat rat increased high, The level of it of acupuncture group decreased, compared with the fat group p.001, This showed: the fat rats have the defeat of leptin and Ins in the body, The acupuncture can lowering this defeat, The level of leptin and Ins of the fat rat in the brain is less than the normal group, The level of leptin of the acupuncture group is high than the fat group, This showed: the acupuncture can increase the transportation of leptin from blood to brain.

本方法所制肥胖大鼠模型具有高体重、高脂、高leptin和高Ins血症的特点，符合人类单纯性肥胖病的临床和病理特征；实验研究显示：针灸能明显减少肥胖大鼠的摄水、摄食量及降低其体重、体脂；针灸能促使白色脂肪细胞直径、面积、体积缩小，减少肥胖大鼠棕色脂肪组织血管周围白色脂肪细胞数量，显示：针灸增强了白色脂肪细胞的代谢，促进了白色脂肪细胞向棕色脂肪细胞的转化：肥胖大鼠PVN神经细胞自发放电频率增加，脑内单胺递质紊乱，针灸通过抑制PVN亢奋的自发放电，调整5-HT水平，达到影响食欲，改善代谢的作用；肥胖大鼠血中leptin及Ins水平增高，与正常组大鼠比有明显差异，提示大鼠体内存在leptin及Ins抵抗，针灸后肥胖大鼠随着体重体脂的下降，血中leptin、Ins水平降低，与肥胖组比均有显著性差异，而针灸后大鼠脑内leptin增加，与肥胖组比P.05，提示：针灸具有改善leptin、Ins抵抗及增加leptin脑内转运的作用。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。