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Prehypertensive subjects versus normotensive subjects had significantly higher body mass index and subscapular skinfold, systolic and diastolic blood pressures, and triglycerides beginning in childhood; higher glucose in adolescence; and higher low-density lipoprotein cholesterol, fasting insulin, and insulin resistance index in adulthood. Hypertensive subjects versus normotensive subjects had higher adiposity measures, SBP and DBP, glucose, and triglycerides beginning in childhood; higher insulin and insulin resistant index in childhood and adulthood; and lower high-density lipoprotein, cholesterol in adulthood.

与正常血压者相比，高血压前期者其幼年期基础体重指数、肩胛下皮肤皱褶厚度、收缩压和舒张压、甘油三脂等指标更高；在青春期血糖水平更高；在成年期低密度脂蛋白胆固醇、空腹胰岛素、胰岛素抵抗指数更高；与正常血压者相比，高血压者在幼年时基础水平的肥胖积分、SBP 和DBP、血糖、甘油三脂等更高；在幼年期和成年期胰岛素和胰岛素抵抗指数水平均更高；在成年期高密度脂蛋白胆固醇水平更低。

The influence of acid rain soaking on thermostability and water vapor permeability of the leather s were investigated.

采用不同的加脂剂对猪蓝湿革进行加脂处理，并将所得到的加脂皮革在人工配制的酸雨中浸泡一定时间，考察了酸雨浸泡处理对加脂皮革透水气性能和耐干热收缩性能的影响。

The results showed that either of the extracted propolis had significant inhibitory effect on the level of triglyceride, total cholesterol, LDL-C,GPT and GOT in serum, and TC, TG and MDA in liver, but were ineffective on HDL-C, MDA, SOD and NO levels in serum. Ethanol extracted propolis also reduced the body weight, liver weight and liver index of hyperlipidemic SD rats, while water extracted propolis were adiaphorous.

结果表明：蜂胶醇提液和水提液均能有效抑制高脂血症SD大鼠血清中的甘油三酯、总胆固醇、低密度脂蛋白、谷丙转氨酶、谷草转氨酶的升高，并且能有效抑制肝脏组织中的TC、TG、MDA的升高，但对血清中的高密度脂蛋白、超氧化物歧化酶、丙二醛、一氧化氮的影响不明显；蜂胶醇提液能有效降低高脂血症SD大鼠的体重、肝重及肝指数，蜂胶水提液对体重、肝重及肝指数的影响则不显著。

Results Fetal Macrosomia group: the rate of obesity is 9.4%, obviously higher than that of the contrast group, 2.03%(χ2=7.4715,P.01), the rate of overweight is 19.4%, higher than that of the contrast group, 3.3%（χ2=18.9434,P.01）;Fetal Macrosomia group: there is a remarkable difference in GLU, ALT, HDL, Insulin, and APN,（P﹤0.05~0.01）,There were marked differences in the aspects of body mass index, the level of blood grease,HDL, ALT, HOMA-IR, adiponectin（P.05~0.01） Conclusion: In adolescence of Fetal Macrosomia weight index, GLU, Insulin and ALT are obviously higher than that of the contrast group; the HDL ,and APN which has great protective effect to angiosclerosis is also absolutely lower than the compare group.

结果：巨大儿组：肥胖率为9.4%，明显高于对照组2.03%（χ2=7.4715，P.01）、超重率为19.4%，高于对照组的3.3%（χ2=18.9434，P﹤0.01）；巨大儿组：血糖、转氨酶、高密度脂蛋白、胰岛素、脂联素方面有显著差异，（P﹤0.05~0.01），结论：巨大儿在青少年期，其体重指数、血糖、胰岛素、转氨酶水平明显高于对照组，对动脉硬化有保护作用的高密度脂蛋白、脂联素明显低于对照组。

III. Studies on the total synthesis of macrophllin type of bicyclo[3, 2, 1] octanoid neolignans ( C-4': endo ) The first total synthetic route of macrophllin type of bicyclo[3, 2, 1]octanoidneolignans ( C-4': endo ) was established based on the rearrangement ofbenzofuranoid and bicyclo[3, 2, 1]octanoid neolignans.

三、Macrophllin型双环[3，2，1]辛烷类新木脂素(C-4'桥环为endo)的全合成研究利用氢化苯骈呋喃类新木脂素和双环[3，2，1]辛烷类新木脂素的重排关系，首次建立了macrophllin型双环[3，2，1]辛烷类新木脂素(C-4'桥环为endo)的全合成路线。

objective the effects of anthocyanin pigment from maize purple plant on resisting lipid peroxidation were investigated.methods the inhibition of anthocanin pigment from maize purple plant was examined in vitro that autcoxudation of lecithin liposome system induced by fe2+.50 mice were randomly divided into 5 groups.vehicle and different dose anthocyanin pigment from maize purple plant were given respectively,and then experimental injury of mice liver was induced to make use of bromobenzene and the content of mda was determined in liver homogenate.results the inhibition rates of anthocyanin pigment from maize purple plant on linoleic acid oxidation was higher that of ascorbic ascorbic acids.the content of mda in homogenate in middle and high dose of pigment were significantly lower than that in low dose and the injured control group.there were no significat differences in the content of mda in homogenate between low dose group and injury control group.conclusion the anthocyanin pigment from maize purple plant have the capability to resist lipid peroxide.

目的 探讨玉米紫色植株色素抗脂质过氧化的作用。方法体外实验测定玉米紫色植株花色苷色素在fe2+引发的卵磷脂脂质体体系中抗氧化活性。体内实验，取50只小鼠随机分成5组，分别给予溶媒和不同剂量的色素，然后采用溴代苯致实验性肝损伤，测定肝匀浆的丙二醛含量。结果在由fe2+引发的卵磷脂脂质体体系中玉米紫色植株色素对脂质过氧化有明显的抑制作用，抑制率随样品的浓度增高而增大，并且明显优于抗坏血酸。在溴代苯致小鼠实验性肝损伤模型实验中，中、高剂量组的丙二醛含量均低于损伤模型组。低剂量组和损伤模型组比较丙二醛含量差异无统计学意义。

Totally 36 male Wister rats were randomly and averagely divided into three groups, and all groups were fed for 6 weeks: control group were fed with basic food; the rats in hyperlipidemia group were fed with hyperlipidemia diet; the rats in hyperlipidemia stress group were given hyperlipidemia diet, and were exposed under the different stressors at the same times, including limit, circumvolve and huddle.

36只Wister雄性大鼠随机平分为3组，均饲养6周，正常对照组喂食普通饲料；高脂组喂食高脂混合饲料；高脂加应激组除喂食高脂混合饲料外，同时给予限制应激、旋转应激、拥挤应激。

A gene sequence of the anthropogenic adiponectin spherical fragment obtained by the invention absolutely accords with a known gene sequence, and compared with the full-length adiponectin, the hydrolyzed anthropogenic adiponectin spherical fragment has stronger biological activity, fast reaction after dosage, good bioavailability and better clinic application prospect, especially when the diabetes patient receives a recanalization treatment after a myocardial infarction, the anemically myocardial damage of the diabetes patients can be eased by the exogenetic dosage.

本发明公开了一种人源性脂联素球状片段用于治疗糖尿病缺血性心脏病药物的应用，本发明所得到的脂联素球状片段的基因序列与已知的基因序列完全相符，与全长的脂联素相比，其水解以后的脂联素球状片段有着更强的生物学活性，而且给药后反应迅速，生物利用度好，有着更好的临床应用前景，特别是对糖尿病患者在发生心肌梗死后接受血管再通治疗时，通过外源性给药，以减轻糖尿病患者缺血心肌损伤。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

It was suggested that the pharmacodynamics and therapeutic function of Qizhi complex prescription to fatty liver were: 1. Adjust lipometabolism: reducing TC and TG; 2. Decreasing fatty degeneration of liver cell; 3. Promoting the convalescence of hepatocellular function; 4. Anti-lipid peroxide: increasing the activation of peroxidase, decreasing the content of products of lipid peroxide. 5. Restraining Kupffer cell function of fatty liver rat; 6. Improving fluidity of hepatocellular microsome and mitochondria.

芪枳合剂治疗脂肪肝的效应及药效学机制为： 1、调整脂质代谢：降低血清甘油三脂和胆固醇； 2、减轻肝细胞脂肪变性； 3、促进肝细胞功能恢复，有效治疗脂肪性肝炎； 4、抗脂质过氧化：提高抗氧化酶活性、降低脂质过氧化产物含量； 5、抑制脂肪肝大鼠Kupffer细胞功能； 6、改善肝细胞微粒体、线粒体膜流动性。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。