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To understand more about the relationship of SOCE with lipid raft,we have studied the influence in cell polarity by mβCD,mβCD can clear the cholesterol of membrane to destroy the integrality of lipid raft.

为了进一步理解SOCE和筏的关系,我们观察了mβCD(甲基-β-环糊精,Methyl-β-cyclodextrin)对中性粒细胞极性的影响。mβCD能够清空中性粒细胞胆固醇,破坏筏完整性,从而可能影响到极性的形成过程。

Methods BALB/c nude mice were subcutaneously transplanted with SCG-7901 tumor cells, then the mice were randomly divided into antisense oligonucleotide group, sense oligonucleotide group and the control group. The HIF-1α ASOND complexed with cationic liposome, HIF-1α SOND complexed with cationic liposome and liposome were injected intra-tumorally in the above groups, respectively.

用人胃癌细胞株SCG-7901建立胃癌裸鼠皮下移植瘤模型,将荷瘤裸鼠随机分为反义寡核苷酸组、正义寡核苷酸组和对照组,瘤体内分别注射阳离子质体包裹的HIF-1αASOND、HIF-1αSOND和空白阳离子质体。

Viral vector mainly contain adenovirus, retrovirus,adeno-associated virus and so on, but it has potential danger of safety; it isrepeled by immune system when it is injected to organism for a greatimmunogenicity. An injection with adenovirus vector with highconcentration, it leads to serious inflammatory reaction of liver. Viralvector such as liposome and polycation are commonly used lately. But,liposome and polycation have low specificness and targetness of genetransfer tissue, have lower transfection efficiency and short period ofgene expression, for they can be phagocytized by endothelial system.

许多的载体,病毒载体和非病毒载体以前已广泛应用,病毒载体主要包括腺病毒,逆转录病毒,腺相关病毒等;但病毒载体在安全性方面存在潜在的危险;免疫原性比较强,注射到机体后很快会被机体的免疫系统排斥,当静脉注射高浓度的腺病毒载体会使肝脏发生严重的炎症反应;非病毒载体目前常用的有质体及多聚阳离子聚合物;但质体和阳离子聚合物介导基因转移缺乏组织的特异性和靶向性,转染效率较低且易被网状内皮系统吞噬,基因表达时间短;因此研制新型的非病毒载体已成为研究的热点,纳米颗粒具有小尺寸效应,表面效应,随着颗粒直径变小,比表面积将会显著增大,故具有很高的化学活性,因而纳米成为了最有应用前景的非病毒载体。

It is suggested that mechanisms protecting epidermis of squamata species from UVB damage may involve in (1) Physical defensive mechanism: the death epidermal layer limited UVB transmitting to the viable cells;(2) Biochemical defensive mechanism: up-regulated CAT may protect skin from reactive oxygen species which may induced by UVB. Moreover, the lipid and proteins in the β-, meso- and α-layer may absorb incident UVB and formed damaged products that were limited in the original site;(3) Cellular defensive mechanism: quick initiating of proliferation of the germinal cells and forming of the new epidermis and shedding out the damaged epidermis shortened the damage process and restricted the damage area.

1物理性防御:角质层和中层阻挡绝大部分UVB透过,最大限度地减轻生发层的损伤;(2)生化性防御:通过上调CAT活性以减轻LVB诱导的活性氧对表皮的损伤,同时角质层蛋白质和中层类可吸收UVB,且形成的有害产物被局限于原位;(3)细胞性防御:通过迅速启动再生修复过程形成新的表皮,及时蜕去积累了类过氧化产物、受损蛋白质和晒斑细胞等的受损表皮,有效防止损伤的持续和蔓延。

Addition of DSPE-PEG-RGDS and Stearyl RGDS in liposomal prescription gives birth to two targetedly thrombolytic liposomes. The former has long circulating function, the latter has no long circularing action but carries two times directing molecules as that carried by the former.

将DSPE-PEG-RGDS和Stearyl RGDS分别掺入膜中制备得到了两种靶向溶栓质体,前者同时具有长循环作用;后者不具长循环功能,但导向分子的携载量为后者的两倍。

Accordingly, the increase in concentration of total adiponectin was primarily caused by a major increase of the HMW subform.

因此,总联素浓度的增高主要是由于高分子量亚型联素浓度的增高所导致。

Levels of total adiponectin and the HMW subform were generally unaffected by nephropathy status defined by urinary albumin excretion rate.

联素和高分子量联素水平均未受肾病分期的影响(以尿蛋白排泄率进行定义

The HDL reduction [HDL-3 subfraction] with the testosterone group was only an average of 9%.

的高密度蛋白减少[高密度蛋白3分支]与睾酮组平均只有9%。

The increased VLDL in hypertriglyceridemic patients is mainly ApoE poor VLDL subfraction.

高甘油三酯血症患者血中升高的极低密度蛋白主要是贫含载蛋白E的亚组份。

SF measurements were taken by Lange calipers (l0g/mm^2 constant pressure) at biceps, triceps, subscapulr and suprailiac sites.

另外,在测量皮厚度时,我们用兰吉测度计(每平方毫米10公克的稳定压力)测量二头肌、三头肌、肩胛下肌以及肠骨上方等四处的皮厚度。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口,替代木托盘,免薰蒸,符合欧盟、北美各国对出口货物包装材料的法令要求;喷涂钢托盘适用于重载上货架之用,托盘表面根据需要制作成平板状、波纹状及间隔形式,满足不同的使用要求。

A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。