能结合的

Moreover, we have successfully applied this model to predict the relative binding free energies for four binding modes of EGFR/quinazoline. The most favorable binding mode identified by MM/PBSA could also be correctly recognized by MM/SAWSA.

我们把SAWSA替代PBSA计算用于结合自由能的计算，结果表明在计算效率大大提高的情况下，MM／SAWSA计算能得到和MM／PBSA计算可比的结果。

Of the five stages deformation, the exact ages of the (2) and (3) were determined by 40Ar/39Ar method as 290 and 259 Ma respectively.2. New results on the metamorphic belts and associated metamorphism of the Xiaopu metamorphic rocksBased on detailed microtextural observations and occurrence of typical metamorphic minerals, five metamorphic belts in the Xiaopu metamorphic rocks are identified. From the north to the south, they are biotite belt, garnet belt, staurolite belt, andalusite belt, and sillimanite belt. I suggested that the metamorphic belts occurred in the Xiaopu area belongs to the high temperature/low pressure series, may have resulted from the later Permian crust extension at ca. 290 Ma.3. I suggest that there may have been a Carboniferous backarc basin along the southern slope of the Harlik Mountain.Detrital Zircon SHRIMP U-Pb dating indicated that the sedimentary age of the Julideneng formation lithic sandstone must be later than late Devonian, most likely is Carboniferous rather than previously thought Precambrian. Analyses on its geologic setting, location of provenance, and sedimentary environment suggest the Carboniferous strata may form in a lagged backarc basin bounded by backarc uplifts.5. Reconstruction of the post-Paleozoic tectonic evolution history of the Harlik MountainThe tectonic evolution of Harlik mountains since the Paleozoic were reconstructed as followings:(1) arc-affinity magmative activities occurred during the middle-Ordovician to early-Silurian;(2) the middle-Silurian to late-Devonian was a back-arc uplift stage;(3) back-arc extension featured the Carboniferous period;(4) post-collisional extension and/then compression during Permian;(5) at the Mesozoic, differential uplift developed; and (6) the late Cenozoic is the intra-continental re-orogen stage.6. Primary estimation of the crust shortening is madeThe folded pre-Mesozoic strata were used to estimate crust shortening along the Harliknanshankou-Koumenzi, Shichengzi-Baishitou, and Qincheng-Xiaopu sections. Their shortening ratios are 16.2%, 19.8%, and 20.1% respectively corresponding crust shortening are 4.3, 9, and 11.3 km.

根据Ar-Ar热年代学研究，精确测定了早二叠世伸展变形和晚二叠世挤压变形的峰期时代分别为290Ma和259Ma.2、提出了关于哈尔里克山南麓小铺一带变质带和变质作用的新认识根据显微观察资料和特征变质矿物的出现，把小铺一带的变质岩由SW向NE方向依次划分为黑云母带、石榴石带、十字石带、红柱石带和矽线石带等变质带；初步确定该区的变质作用属于中温-低压型，变质作用发生的时代为290Ma左右，是该区早二叠世地壳伸展的产物。3、首次提出哈尔里克山南麓在石炭纪可能发育弧后盆地的新观点根据哈尔里克山南麓原"居里得能组"岩屑砂岩的碎屑锆石SHRIMP U-Pb定年，确认这套地层的沉积不早于晚泥盆世，很可能是石炭纪，而不是前人所说的前寒武纪；结合对其区域地质背景、源区位置和沉积环境分析，推测该区石炭纪可能为滞后弧后盆地和弧后隆起区构造背景。4、进一步证明哈尔里克山不发育与岛弧演化相关的泥盆纪岩浆活动根据对代表性闪长岩和花岗岩的锆石SHRIMP年代学研究获得的新资料，结合该区已有相关资料的综合研究，确定哈尔里克山岩浆岩分别形成于奥陶纪-志留纪和石炭纪晚期-二叠纪，不存在泥盆纪的岩浆岩，进而认为该区泥盆纪不属于岛弧环境。5、重建了哈尔里克山古生代以来的地质演化过程根据区域资料以及本次研究所获得的资料，把哈尔里克山古生代以来的构造演化划分中奥陶世-早志留世为岛弧、中志留世-晚泥盆世为弧后区、石炭纪弧后伸展、二叠纪为后碰撞伸展与挤压、中生代差异隆升和晚新生代陆内再造山过程等构造阶段。6、初步估算了哈尔里克山地壳缩短率和缩短量根据前中生代地层褶皱估算的哈尔里克山南山口-口门子、石城子-白石头和沁城-小铺三条剖面的地壳缩短率分别为16.2%、19.8%和20.1%，相应的地壳缩短量分别为4.3km、9km和11.3km。

As the complete characteristic curves of reversible pump turbine are often used to calculate the instantaneous parameters, this paper studies the characteristic curve and the wicket closure and opening law in pumped storage plants.Chapter 1 presents the importance and the necessity of this study and reviews the previous related research on hydraulic transient process and valve regulation in pumped storage plants.Chapter 2 analyzes the six collected characteristic curves of reversible pumped turbine and studies their diversification from the point of view of specific speed. The six collected discharge and moment curves with maximum efficiency have been fitted to piecewise continuous curves. This curve-fitting procedure is listed.Chapter 3 takes Liyang Pumped storage plant as an example and analyzes the effect of different characteristic curves on regulation guarantee parameters and the variety of its trochoid during the same operation status.Chapter 4 takes three pumped storage plants with different heads as examples and studies the characteristic of coordinated closure with wicket gate and ball valve and its effect on dynamic pressure in the spiral case, inlet pressure in the draft tube and the rise of rotating speed.Chapter 5 summarizes this paper and point out what should be done in the future research.

由于在过渡过程分析计算中，需要频繁利用可逆式机组的全特性曲线推求机组的瞬时参数，所以本文就特性曲线及关闭规律问题进行了研究，其主要内容如下：第1章，指出本文研究的意义和目的，回顾前人对水力过渡过程、抽水蓄能电站及阀调节的研究成果，在此基础上提出本文的研究内容；第2章，针对收集到的六套特性曲线，从比转速的角度出发来研究可逆式机组特性曲线的变化规律；并对六套曲线的最高效率流量和力矩曲线进行分段拟合，得到各分段函数的具体形式，再通过举例说明最高效率曲线的拟合步骤；第3章，以溧阳抽水蓄能电站为实例，分析讨论不同比转速特性曲线对调保参数造成的影响及对于相同工况其轨迹线的变化；第4章，结合高、中、低三水头段抽水蓄能电站，在导叶直线关闭的基础上，研究导叶与球阀协联关闭规律的特点及对蜗壳动水压力、尾水管进口压力及转速上升造成的影响；第5章，总结全文，提出今后研究的重点和方向。

After 100 h thermal exposure at 1050 ℃, the surface Al2O3 scales are continuous, dense, and only very little amounts of alloy elements diffused from the substrate is detected in the overlayer.

一步法制备能提高含扩散阻挡层多层体系的界面结合强度， DB在恒温和循环氧化过程中能保持很好的抑制元素扩散的能力。

A difference in pattern classification on 3D CT was found between benign and malignant SPN. Conclusion: 3D CT can not only stereoscopically demonstrate the abnormal signs of SPN, but can also provide information concerning the anatomic relationship between SPN and adjacent bronchi, vessels and chest wall. Combined 3D with 2D CT, the diagnosis can be improved.

三维重建技术不仅能三维显示SPN的异常表现，而且能显示结节与支气管、血管和胸壁是的解剖关系及形态学特征。3D CT结合2D CT有助于提高诊断准确性，是鉴别SPN良恶性的有效的影像学检查方法。

But two questions are still harrying the translation teachers: what translation theoretical knowledge should be taught in class? And how to combine the theoretical content with students' translation activities in their teaching? This paper argues that, first of all, a scientific, systematic and practical system of theoretical content to be taught should be specified and brought into the framework...

要在翻译教学中真正实现理论与实践相结合，首先必须根据翻译理论在翻译教学中的作用和教学对象的实际需要，从认识论的角度确立一个明确的、能体现科学性、系统性和实用性三大原则的翻译理论教学体系；同时，翻译教师必须在教学中将翻译理论的传授与学生的翻译实践紧密地结合起来，用所学的理论知识和技巧去解释和论证学生在翻译实践中遇到的问题和难点，使学生由感性认识发展到理性认识，从而对整个翻译活动获得一个全面完整的认识，树立正确的翻译观

The results showed as:(1)Gegen decreases fasting insulin and insulin resistance index and increases insulin sensitive index of rats of insulin resistance induced by dexamethasone significantly;(2)Gegen can improve glucose tolerance of rats of insulin resistance but not to alloxan indued diabetes mice;(3)Gegen increases glucose intake of 3T3-L1 adipocytes and improves the insulin resistance of 3T3-L1 adipocytes induced by dexamethasone significantly;(4)Gegen can activate peroxisome proliferator- activated receptor gamma, make it bind to PPAR response elements;(5)Gegen can up-regulate mRNA expression of PPAR v ,aP2 and adiponectin.

结果表明：①葛根显著降低地塞米松诱导的胰岛素抵抗大鼠血清胰岛素水平和胰岛素抵抗指数，升高胰岛素敏感指数，改善大鼠的胰岛素抵抗；②葛根显著改善胰岛素抵抗大鼠的糖耐量，但对四氧嘧啶糖尿病小鼠的糖耐量没有明显的作用；③葛根显著增加胰岛素抵抗3T3-L1脂肪细胞对葡萄糖的摄取，改善地塞米松诱导的3T3-L1脂肪细胞的胰岛素抵抗；④葛根能促进HepG2肝癌细胞过氧化物酶体增殖物激活受体γ与靶基因的特异DNA序列结合，对PPARγ及其下游基因的转录具有激活作用；⑤葛根能够促进PPARγ及其下游基因脂肪酸结合蛋白(aP2)、脂联素mRNA的表达。

The authors introduce the geometrical characteristics and topological characteristics describe each junction of ARG,so the algorithm can not only recognize polyhedrons of different shape but also distinguish between polyhedrons that are of the same shape but their sizes and proportions are different.

结合几何特征和拓扑特征表示ARG中的每个结点，不仅能识别不同形状的目标，而且能把拓扑结构相同，但各部分大小、比例不相同的目标区分开。

Strong professional and technical, management class, you will provide the series of industrial brush products, there is steel brush series, Article brush series, roller brush, wire polishing brush series×, all kinds of abrasive wire brushes, industrial-sik brush roller series, bottle brush series, Channel brush, disc brush series, widely used products and food, printing and dyeing, textile, glass, leather, metal smelting, mining, furniture, machinery manufacturing and other industries, in services for Chinese enterprises, we had a lot of success case, Baosteel dust cleaning brush, cleaning the boiler of Shanghai Petrochemical, Jiangsu Pesticide Factory Automation clearance bottles, Qingdao Nissin Food Machinery and other industries, we have a combination of our excellent design ability and practical experience, with our customers in this area be a new perfect combination of technology, designed to make our products better most reasonable application in industry.

专业技术雄厚，管理一流，将为你提供各系列工业刷产品，产品有钢带刷系列、条刷系列、滚筒刷、钢丝打磨抛光轮刷系列、各类磨料丝刷、工业植毛刷辊系列、瓶刷系列、通道刷、圆盘刷系列等，产品广泛应用与食品，印染，纺织，玻璃，皮革，金属冶炼，矿山，家具，机械制造等行业，在为中国企业服务中我们曾有很多成功的案例，宝钢的烟尘刷洁，上海石化的锅炉清洗，江苏农药厂的清瓶自动化，青岛日清食品机械等各行业，我们结合了我们优秀设计能力与实践经验，与我们的客户在这领域加以以新的工艺完美的结合，使我们的设计出来的产品，更能最合理的应用在工业上。

Of the five stages deformation, the exact ages of the (2) and (3) were determined by 40Ar/39Ar method as 290 and 259 Ma respectively.2. New results on the metamorphic belts and associated metamorphism of the Xiaopu metamorphic rocksBased on detailed microtextural observations and occurrence of typical metamorphic minerals, five metamorphic belts in the Xiaopu metamorphic rocks are identified. From the north to the south, they are biotite belt, garnet belt, staurolite belt, andalusite belt, and sillimanite belt. I suggested that the metamorphic belts occurred in the Xiaopu area belongs to the high temperature/low pressure series, may have resulted from the later Permian crust extension at ca. 290 Ma.3. I suggest that there may have been a Carboniferous backarc basin along the southern slope of the Harlik Mountain.Detrital Zircon SHRIMP U-Pb dating indicated that the sedimentary age of the Julideneng formation lithic sandstone must be later than late Devonian, most likely is Carboniferous rather than previously thought Precambrian. Analyses on its geologic setting, location of provenance, and sedimentary environment suggest the Carboniferous strata may form in a lagged backarc basin bounded by backarc uplifts.5. Reconstruction of the post-Paleozoic tectonic evolution history of the Harlik MountainThe tectonic evolution of Harlik mountains since the Paleozoic were reconstructed as followings:(1) arc-affinity magmative activities occurred during the middle-Ordovician to early-Silurian;(2) the middle-Silurian to late-Devonian was a back-arc uplift stage;(3) back-arc extension featured the Carboniferous period;(4) post-collisional extension and/then compression during Permian;(5) at the Mesozoic, differential uplift developed; and (6) the late Cenozoic is the intra-continental re-orogen stage.6. Primary estimation of the crust shortening is madeThe folded pre-Mesozoic strata were used to estimate crust shortening along the Harliknanshankou-Koumenzi, Shichengzi-Baishitou, and Qincheng-Xiaopu sections. Their shortening ratios are 16.2%, 19.8%, and 20.1% respectively corresponding crust shortening are 4.3, 9, and 11.3 km.

根据Ar-Ar热年代学研究，精确测定了早二叠世伸展变形和晚二叠世挤压变形的峰期时代分别为290Ma和259Ma.2、提出了关于哈尔里克山南麓小铺一带变质带和变质作用的新认识根据显微观察资料和特征变质矿物的出现，把小铺一带的变质岩由SW向NE方向依次划分为黑云母带、石榴石带、十字石带、红柱石带和矽线石带等变质带；初步确定该区的变质作用属于中温-低压型，变质作用发生的时代为290Ma左右，是该区早二叠世地壳伸展的产物。3、首次提出哈尔里克山南麓在石炭纪可能发育弧后盆地的新观点根据哈尔里克山南麓原&居里得能组&岩屑砂岩的碎屑锆石SHRIMP U-Pb定年，确认这套地层的沉积不早于晚泥盆世，很可能是石炭纪，而不是前人所说的前寒武纪；结合对其区域地质背景、源区位置和沉积环境分析，推测该区石炭纪可能为滞后弧后盆地和弧后隆起区构造背景。4、进一步证明哈尔里克山不发育与岛弧演化相关的泥盆纪岩浆活动根据对代表性闪长岩和花岗岩的锆石SHRIMP年代学研究获得的新资料，结合该区已有相关资料的综合研究，确定哈尔里克山岩浆岩分别形成于奥陶纪-志留纪和石炭纪晚期-二叠纪，不存在泥盆纪的岩浆岩，进而认为该区泥盆纪不属于岛弧环境。5、重建了哈尔里克山古生代以来的地质演化过程根据区域资料以及本次研究所获得的资料，把哈尔里克山古生代以来的构造演化划分中奥陶世-早志留世为岛弧、中志留世-晚泥盆世为弧后区、石炭纪弧后伸展、二叠纪为后碰撞伸展与挤压、中生代差异隆升和晚新生代陆内再造山过程等构造阶段。6、初步估算了哈尔里克山地壳缩短率和缩短量根据前中生代地层褶皱估算的哈尔里克山南山口-口门子、石城子-白石头和沁城-小铺三条剖面的地壳缩短率分别为16.2%、19.8%和20.1%，相应的地壳缩短量分别为4.3km、9km和11.3km。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。