能混合的

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

You can say i'm selfish, ignorant and that i don't care gotta understand i took your pain away from your own fears putting you through this would shatter your hope and dreams you just don't see it right now till it hits your own scene believe me i care it's just that this world is all about survival dealing with denial it's our own personal issue and trial Chorus 2x Only in deep down dreams i feel your face as i stare off into the lost open space or ratherly pounds of thousands pace concentration gets hard when i'm at work mixed up between dreams and reality, yes it hurts i find myself hiding just so i can feel ya true love, i never achieve it so loneliness still attached to my everyday instinct so many new faces dashing through been searching forever just tryna find the real you ah, imagine you and i at that place, that place that separates pain away from peace in the country field we dash through just ,you and i as we join hands and hands spread your wings and sooth with me to another land over the ocean as we freeze through the breeze these memories will not be put to rest learn to move on and live your life at it's best forward towards another day waking up stunned again damnn, i'm just dreaming away...

你可以说我自私，无知，而且我也不在乎爱是理解我把你的疼痛远离自己的担心让你通过这将打破您的希望和梦想你刚才没有看到它现在直到访问您自己的舞台相信我，我照顾只是，这个世界就是生存处理拒绝这是我们自己的个人问题和审判合唱团2 只有在内心深处的梦想我觉得你的脸我瞪了进入了开放空间或ratherly磅的数千步伐浓度会很难当我在工作混合了梦想与现实之间，是疼我发现自己隐藏，所以我能感觉到亚真正的爱情，我从来没有做到这一点如此孤独仍然附在我的日常本能这么多新的面孔通过破灭一直在寻找永远只是tryna找到真正的你啊，你可以想象，你和我在那个地方，那个地方分离疼痛远离和平在该国的领域，我们通过破折号刚才，你和我，因为我们携起手来，双手展开你的翅膀和抚慰我到另一个陆地的海洋，因为我们通过冻结微风这些记忆将不会平息了解进入你的生活和居住在最好迈进新的一天起床震惊再次damnn ，我只是梦想远离找到了

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。