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PremiseN,N-Dimethylformamide, a good organic solven with low noxiousness, is mostly used in extractions, organic synthesises, dyestuffs, fibres, leathers, pharmacies and so on.

前言 二甲基甲酰胺(N,N-dimethylformamide,DMF)作为一种良好的有机溶剂广泛应用于纤维、皮革、染科及制药等工业生产中,属于低毒类物质。

Employing CuI(5 mol%), N,N-dimethylglycine hydrochloride(10 mol%) and K_2CO_3(2 equiv.) in refluxing THF as the optimized reaction conditions,the four-membered 4-alkylidene-2-azatidinones could be efficiently synthesized.

当以3-溴-3-N-苯基-丁烯酰胺为底物,在5 mol%CuI为催化剂,10 mol%N,N-二甲基甘氨酸盐酸盐为配体,2当量K_2CO_3作碱,THF回流的反应条件下,可以高效的合成2-亚甲基-4-氮杂环丁酮类化合物。

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