胺化产物

METHODS 3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol was reducted with lithium and ammonia,then the intermediate was hydrolyzed in oxalic acid and reacted with malonic acid to get 3,3-dimethoxo-7α-methylestra-5(10)-en-17-ol(compound 4),which was oxidated by pyridium bichromate ,reacted with acetylene,and hydrolyzed in oxalic acid again to get the product tibolone.

方法以3-甲氧基-7α-甲基雌甾-1，3，5(10)-三烯-17β-羟基为起始原料经锂胺还原、草酸水解、缩酮化得3，3-二甲氧基-7α-甲基雌甾-5(10)-烯-17β-羟基(化合物4)，然后用温和的氧化剂重铬酸吡啶盐氧化、炔化、再水解得目的产物。

Methods 4-Hydroxybenzonitrile (2) as the starting material was transformed to 4-hydroxy-thiobenzamide (3) via thioformylation. And ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (4), which was synthesized via cyclization from 3, was treated with hexamethylenetetramine to generate the intermediate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate (5). The target compound febuxostat (1) was obtained from 5 by etherification, cyanidation, hydrolysis.

以羟基苯腈为原料，经硫代甲酰化得到对羟基硫代苯甲酰胺(3)，3经环合得到2-（4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(4)，4与乌洛托品反应，得到中间体2-（3-甲酰基－4-羟基苯基）－4-甲基－噻唑－5-羧酸乙酯(5)，之后再经醚化、氰化、水解得到目标产物(1)。

Using ethylenediamine, urea, methanal and formic acid as base material, 1, 3-dimethyl-2-imidazolidinone was prepared via cyclization reaction and methylation.

以乙二胺、尿素、甲醛和甲酸为原料，经过环化和甲基化反应制得目标产物1，3-二甲基－2-咪唑啉酮(1，3-DMI)。

The method is based on a diazotion-coupling reaction between benzidine and hydrochloric acid naphthyl ethylenediamine in a hydrochloric acid medium.

在酸性条件下，亚硝酸盐与联苯胺重氮化，再与盐酸萘乙二胺偶联生成蓝色产物，该产物在578 nm处有最大吸收值，并由此建立了一种简单、快速、灵敏的亚硝酸盐测定方法。

The third part of this thesis is reactive simulating calculation In this section, some well-known auxiliaries are selected to compute in density functional theory B3LYP on Gaussian 03, from which the relationship between reaction active energies of transition states and enantiomeric excess of chiral products homoallylic alcohols isobtained based on relative reactive ratio theory. Using this relationship, calculations on the reaction of more than eight auxiliaries with four other aldehydes are carried out in AMI and MNDO, proving that N,N\'-dibenzyl tartamide has higher enantioselectivity than others in this reaction.

第三部分为计算化学部分，运用密度泛函理论B3LYP方法在Gaussian03软件上对已经报道的几种手性配体参与的醛不对称烯丙基化反应过程进行模拟计算，基于相对反应速率理论找出两种构型过渡态间活化能的差异与产物光学收率之间的关系；并以此为基础，用AM1和MNDO方法对上述合成的几种配体控制的反应过程进行量化计算，从而在理论上证实了N-苄基酒石酸二酰胺配体在醛的不对称烯丙基化反应中具有较高的立体选择性。

In a similar way, using N,N\'-dibenzyl tartamide as auxiliary,-(2-methyl)allyl-2-chloro-phenyl-methyl azide, a vital intermediate of Repaglinide, can be prepared via asymmetric allylation of o-chlorobenzaldehyde in

产物经氧化和碘加成内酯化反应得到阿伐他汀中间体(3R，5S)-3-羟基-5-碘甲基戊内酯(10)；将N-苄基酒石酸二酰胺用于邻氯苯甲醛的不对称烯丙基化反应以较高光学收率得-甲基烯丙基-2-氯苯基-甲基醇

The results indicate that polyborazine precursor prepared at 150℃ for 10 h and propylamine/isopropylamine molar ratio 2:1, could possess nearly linear molecule skeleton and he prone to melt spinnability. When melt at 90℃, the precursor fibers are prepared with average diameter 10-20μm and BC1.27 N1.52 H structure. After curing process and sintered in NH3 at 1200℃, the near-stoichiometric BN fibers was obtained, which proved this precursor is apt for preparation of BN fibers.

结果表明，当正丙胺／异丙胺摩尔比为2：1，聚合温度为150℃，反应时间为10h时，合成产物具有近似线性分子结构，熔点为90℃，具有良好的成丝性，可获得平均直径10~20μm，组成为BC1.27N1.52H的先驱体纤维，先驱体纤维再经不熔化处理及1200℃氨气高温锻烧等工艺可获得近化学计量比的氮化硼纤维。

The invention relates to condensation products comprised of cyclic carboxylic acid anhydrides of dicarboxylic acids, tricarboxylic acid anhydrides or tetracarboxylic acid anhydrides and difunctional polyamines, especially polyoxyalkylene amines.

本发明涉及由二元羧酸的环状羧酸酐、三羧酸酐或四羧酸酐和二官能化多胺，特别是聚氧化烯胺制备的缩合产物。

The products include antioxidants,blowing agents,organic solvents, intermediates for pesticides,drugs and dyestuffs,perfumes,water glass,silicates,molybdenum compounds,graphite series,activated carbon,plasticizers,flame retardant,heat stabilizers,food additives and chemical reagents,etc.

注册商标有&鹿牌&合成樟脑，&桃浦&牌合成樟脑副产物和其他化工产品，&金牛&牌抗氧剂，发泡剂，水合肼，二甲基乙酰胺，二甲基乙醇胺，&海球&牌硅胶系列，&飞铃&牌磷氯，双乙烯酮衍生物，磷酸酯，乙烯利等，&泉字&牌，&水晶&牌各类泡化碱系列，&上胶&牌钼类化合物，石墨类产品系列。

The complexes areneutral as shown by values of molar conductivity in aqueous solution, namely,〓 The crystal structure determinations show that, in complexes, metal ions werecoordinated by four nitrogen atoms and form slightly distorted square planar configuration,relationship between fluorene ring plane and coordination plane is similar to those betweenpeptide planes of β-folding in proteins. The complex molecules linked by hydrogen bonds formone dimension chain or two dimension network structure.

摩尔电导测定表明他们都是二氧四胺中酰胺氮去质子化后形成的产物。X-射线衍射晶体结构测定表明〓的铜、镍配合物的配位多面体都是稍微畸变的平面正方形，配合物分子中芴基平面与配位平面的关系类似于蛋白质β-折叠结构中肽平面之间的关系，配合物分子之间通过氢键连接成一维链状或二维网状结构。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。