胺化

Deamidation has been proposed to serve as a molecular timer, regulating variant cellular responses, including protein turnover, development and cellular aging.

去胺基化被认为是调控细胞反应的分子时钟，包括蛋白质转换率，细胞发育和细胞老化等。

In addition, ectopic expression of deamidation forms of Bcl-xL sensitized the SKOV3-ip1 cells to cisplatin to a level equivalent to that caused by overexpression of E1A.

因此，由实验结果可以推论诱导Bcl-xL去胺基化对於E1A所调控增加卵巢癌细胞SKOV3-ip1对cisplatin的敏感性扮演著一个重要的角色。

Previously study shows that Bcl-xL deamidation is induced in response to cisplatin treatment in the absence of Rb, and Bcl-xL deamidatioon alters its antiapoptosis function.

之前的研究更显示在无Rb的细胞中当Bcl-xL 受到抗癌药物 cisplatin 刺激发生去胺基化后，会失去其原有抗细胞凋亡的功能。

It is known that adenovirus E1A inactivates Rb normal function by directly binding to Rb. Thus, we reason if E1A blocks the normal function of Rb, it may lead to cisplatin-induced deamidation of Bcl-xL and sensitize the p53-null ovarian cancer cell, SKOV3-ip1 cells, to cisplatin.

过去已知腺病毒E1A会藉由与Rb结合而抑制它的正常功能；因此我们推论若E1A抑制Rb的正常功能之下，cisplatin的处理应该可以导致Bcl-xL 的去胺基化并且使没有p53的卵巢癌细胞SKOV3-ip1对cisplatin较敏感。

From in vitro alkaline pH assay and site-directed mutagenesis of Bcl-xL at two potential deamidation sites, where Asn 52 and 66 were replaced by Ala or Asp residues, we concluded that this Bcl-xL modification was due to deamidation.

此外，外送去胺基化Bcl-xL的表现，也会使SKOV3-ip1细胞对cisplatin较为敏感；而其效果是与E1A增加cisplatin之敏感性相等。

When E1A mutant containing CR2 domain deletion expressed in ovarian cancer cells that contain wild type Rb, we detected low E2F activity. Also, Bcl-xL deamidation was suppressed and the cells were survived under cisplatin treatment in E1A mutant transfected cells.

故当E1A mutant (CR2 domain deletion)在含wild type Rb的卵巢癌细胞中表现时，我们侦测到E2F活性较低且Bcl-xL去胺基化现象被抑制，这使得细胞对抗癌药物 cisplatin具有些微抗性，存活率上升。

A hyperbranched macromonomer (3) was synthesized with maleic anhydride,diethanolamine,o-phthalic anhydride by step polymerization,take advantage of the different activities of functional groups.

以顺丁烯二酸酐、二乙醇胺、邻苯二甲酸酐等为原料，利用官能团活性的差异，通过逐步展开的方法合成了含有双键和端羟基的聚型分子结构的超支化大单体(3)。

After analyzing the reaction mechanism through literature, we think the reaction from diethanolamine to iminodiatic salt is composed of two steps—reaction from alcohol to aldehyde and the disproportionation reaction of the aldehyde. The selectivity, conversion, rate of this reaction are mainly attributed to the capability of this catalyst.

通过查阅文献资料，分析了反应机理，认为二乙醇胺脱氢生成酸是由两步反应组成─醇脱氢生成醛与醛的歧化，催化剂的性能是影响反应转化率、选择性及反应速度的主要因素，确定了采用沉淀法制备Cu/ZrO2做催化剂。

And then the intermolecular reductive cyclization reaction of N,N-diethyl-o-nitrobenzenesulfonamide with nitriles promoted by samarium diiodide was studied. 2H-1,2,4-Benzothiadiazine 1,1-Dioxides were prepared in good yields under mild and neutral conditions.

然后研究了二碘化钐促进的邻硝基N，N-二乙基苯磺酰胺与腈发生的分子间交叉还原偶联反应，一步合成了2H-1，2，4-苯并噻二嗪-1，1-二氧化物。

Studing on samarium diiodide promoted asymmetric intramolecular reducing coupling reactions, we have made the resolution of the racemic biaryl dials by using enantiomeric N-tert-butanesulfinamine as the resolving reagent successfully and thus obtained a series of axially chiral biaryl dials with high enantiomeric excess.

中文摘要在二碘化钐促进的分子内不对称还原偶联反应中，我们不仅对联芳基二醛底物的合成路线进行了优化，还发现N-叔丁基亚磺酰胺辅基可以作为手性试剂，成功地对联芳基骨架二醛化合物进行拆分，得到高对映体过量的轴手性二醛类化合物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。