胺化

The key step involves reduction-amination of benzamine and -acetonide glycealdehyde 20 synthesized from cheap and available ascorbic acid . The hydrolysis product of 21 condensed with triphosgene to get 6, key intermediates of Linezolid and Eperizolid. After a series of reactions, we got Linezolid and Eperizolid in reasonable yields and purity. The spectrum and 〓 values of compounds 6 and other intermediates were identical with literature reported.

我们以国内非常便宜易得的维生素C为原料合成得到-丙酮保护的甘油醛20，20和取代苯胺经还原胺化反应制备得到二噁烷21，21水解后与三光气缩合成环得到利奈唑酮和埃皮唑酮的关键中间体6.6经一系列的反应合成得到了利奈唑酮和埃皮唑酮。6及一些中间体的〓D值与文献报道的数据相吻合。

In this thesis, a reductive amination was used to prepare compound 16 with the boronic acid moiety. The moiety can provide covalent interaction with sugars.

本论文中，合成化合物16，是将化合物15与2-甲醯苯硼酸用还原胺化法而得到；其含有硼酸部分，可以与醣类分子以共价键键结。

Starting with two reactive methylene compounds, ethyl cyanoacetate and malononitrile, two 5-amino-1H-pyrazoles were prepared through the intermediates ketene dithioacetal.

从两个活泼亚甲基化合物开始，经过乙烯酮二硫代缩醛中间体，合成了两个5-氨基-1H-吡唑，以这个两个化合物为中间体，与芳香族和脂肪族α-溴代酮反应，而后经酸催化亚胺化互变异构后得到含咪唑并[1，2-b]吡唑甲硫醚类化合物6a-6g。

The glucose, as raw material, underwent glycuronic inner ester 109, cyclohexanone 113 and amination reduction important process to afford the target product in 13 steps.

本文通过大量的摸索和实验，由葡萄糖出发经过制备葡萄糖内酯109、制备环己酮113及还原胺化总计13步反应以总收率25.3%制备得到伏格列波糖。

And TM was carefully added to the solution of photo-PAE to form a PSPI solution containing TM. The composite filmcast from PSPI-TM can be developed using NMP. When the content of Ti〓 incomposite film was beyond 3%, a heateddeveloper had to be used for the successful development of the composite film.Compared with corresponding ester-type PSPI, D〓 of PSPI-TM increasedrapidly with the content of TM in the composite.

光刻实验发现这种含TM的PSPI光刻胶膜比相应的酯型PSPI光刻胶膜难显影，一般需NMP这样的强溶解性能的溶剂作为显影液，才能顺利显影，当Ti〓含量大于3％(基于酰亚胺化后PI的量)，必须升高温度才能顺利显影；这种含 Ti的PSPI光刻胶在感光性能上也比相应的酯型PSPI光刻胶低很多倍，形成50％留膜率所需的曝光剂量随TM含量的增加，而大幅度地增加。

Starting with commercial available tosylmethyl isocyanide and but-2-enoic methyl ester, pyrrolo[2,1-f][1,2,4]triazine derivatives was prepared by twelve-steps process in total yiled of 5.0%~8% via pyrrole and pyrrolo [2,1-f] [1,2,4] triazine ring formation, substitution and amination reactions etc.

本文以简单的对甲基苯磺酰甲基乙腈和反-2-丁烯酸为原料，经过形成吡咯，吡咯并[2，1-f][1，2，4] 三嗪环，取代，酰胺化等等12步反应，合成了结构新颖的吡咯并[2，1-f][1，2，4] 三嗪衍生物，总收率达5%～8%。

The appropriate conditions of polyaminating reaction was that oxycellulose chloride in 200mL DMSO was heated to 100℃with stirring,then was dropwised 10mL A2.3 and A3.4 separately,remaining the temperature for 12h,after pH was justed to 4-5,the products were obtained in 46%yield.

确定多胺化反应的较佳条件：在200mL DMSO搅拌加热至100℃，滴加A2.3和A3.4各10mL，维持温度反应12h，在酸性条件(pH：4-5)下生成，产率大约在46%左右。

Compared with theoretical values 49.0%C,7.8%H,17.1%N the elemental analysis results of YXA2.3 that was 45.1%C,4.7%H and 11.1%N showed that oxycellulose chloride were aminated only partially in about 45%yield because of their huge molecular volume.

对YXA2.3进行有机元素分析结果为：C 45.1，H 4.7，N 11.1(理论值为：C 49.0，H 7.8，N 17.1)，其中11.1＜17.1，4.7＜7.8，这是由于大分子的特性，氧化纤维素的氯化物只部分发生的胺化。

The effects of imidization method,coagulation bath and temperature were studied on the structure and separation performance of polyimide membrane,prepared by using pyromellitic dianhidride and 4,4′-oxydianiline as raw materials.

针对以均苯四甲酸二酐和4， 4′-二氨基二苯醚为原料合成聚酰亚胺的过程，研究了亚胺化方法、凝胶浴组成与温度等条件对膜的结构和分离性能的影响。

Ultra-thin freestanding polyimide films of 100 nm thickness were formed by sequential evaporation of 4,4'-diaminodiphenyl ether and pyromellitic dianhydride precursor monomers followed by a thermal treatment of 150 ℃ 1 h and 350 ℃ 2 h.

采用分层蒸镀法，在玻璃基片上依次蒸镀二氨基二苯醚和均苯四甲酸二酐两种单体，然后在空气环境中对样品进行不同温度和时间的热亚胺化处理，使二者在交界面上反应生成聚酰亚胺。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。