胸腺细胞

Thymus and autoimmunity: production of CD4+CD25+ naturally anergic and suppressive T cell as a key funtion of the thymus in maintaining immunologic selftolerance.

在人、大鼠和小鼠中有大约3%-10%的CD4+CD8-单阳性胸腺细胞共表达CD25表面分子，这些细胞能够阻止包括自身免疫性胃炎、自身免疫性小肠炎和自身免疫性糖尿病等在内的多种自身免疫性疾病的形成和发展［8-10］。

Interleukin-2(IL-2) activity by thymocyte (C57BL/6-8 mice) proliferation assay and fibroblast(L929 fibroblasts) cytotoxicity assay has been found in supernatant of mitogen-stimulated splenocyte cultures of grass carp Ctenophaxyngodon idellus, Chinese soft-shelled turtle Trionyx sinensis.

摘 要：用刀豆蛋白A刺激诱导草鱼和中华鳖脾细胞，收集细胞培养上清液，用小鼠胸腺细胞增殖试验和对小鼠L929细胞系杀伤试验检测上清液中白细胞介素-2(简称IL-2)活性。

Glucocorticoids are effective in inducing apoptosis via the uncharacterized mechanisms in many hematological malignancies. GC-induced apoptosis is initiated by, and strictly dependent upon, the interaction of GC with its receptor, the GR.

糖皮质激素(glucocorticoid，GC)通过与其特异性受体-糖皮质激素受体(glucocorticoid receptor，GR)结合，不仅可诱导未成熟胸腺细胞凋亡，而且对急性白血病细胞、淋巴瘤细胞、骨髓瘤细胞等均有促凋亡作用，诱发凋亡正是应用糖皮质激素治疗白血病的分子生物学基础。

The inoculation of MDV in general indued to decrease the production of IL-2、 IFN-γ-Th〓 cytokines in vitro, and there are differences between spleen and Thymus lymphocyte on the production of IL-2 in vitro, only thymus lymphocyte IL-2 prodution increased transient in early time. The cytotoxity TNF induced in thymus and spleen lymphocyte and bone marrow macrophage shown a simillar curve of"V"shape. MDV infection cause cell-mediated immune declines.

MDV接种总体上降低IL-2和IFN-γ-Th〓细胞因子体外诱生，其中IL-2体外诱生在胸腺细胞和脾淋巴细胞有差别，前者有早期短暂增强作用；而对TNF在上述两种细胞和骨髓巨噬细胞的诱生作用呈现类似规律，即呈现&V&形曲线，在接种后早期（1~5天）和25天升高，而在10天开始下降，至第20天降至低谷，MDV感染导致雏鸡细胞免疫水平下降，促进MD发病。

When normal rat thymocytes were cocultured with serum prepared from castrated animals, the proliferative activity of thymocytes was enhanced.

当正常的胸腺细胞以去势动物的血清来培养时，它的增殖活性也增强了。

The rats were killed by cutting theirnecks and physical blood was taken for preparing serum, interleukin 2 (IL-2) was detected by radioimmunoassay ; the spleen was taken for measuring ConA-induced reaction of lympho- cyte proliferation and induced production of IL-2; and the activity of induced production of spleen's IL-2 was determined by the means of cell proliferation of mouse thymus; the skin and trachea were taten for slice with paraffin wax, dyeing with methybenzoamine blue so as to survey mast cells .

将大鼠断头留取躯干血制备血清，用RIA法检测白细胞介素2（IL-2）；取脾脏行ConA诱导的淋巴细胞增殖反应测定和IL-2诱生；并用小鼠胸腺细胞增殖法检测脾IL-2诱生活性；取皮肤和气管做石蜡切片、甲苯胺兰染色检测肥大细胞，结果显示：应激组较对照组脾淋巴细胞增殖降低，cpm分别为9466±3.17和24019±3879（P.001）；MC明显减少，分别为8.6±3.0/HP和25.4±3.7/HP（P.001），前组形态异常较其甚（MC多较小，呈多角或不规则状），且组织中可见分散的崩解颗粒。

RESULTS ① TLSFJM could induce apoptosis of PHA plus IL-2-activated mouse thymo cytes;② TLSFJM could induce apoptosis of alloantigen activated human pe ripheral blood mononuclear cells and hold the cell cycle at G1 phase;③ TLSFJM neither influenced the CD25 expression nor induced apoptosis of PMA activated human PBMC .

结果 TLSFJM 在体外可诱导PHA/IL-2活化的小鼠胸腺细胞的凋亡。 TLSFJM 在体外可诱导alloantigen活化的人外周血单个核细胞的凋亡，且把细胞周期阻遏在G1期。 TLSFJM 对PMA诱导的人PBMC活化抗原CD25的表达无明显影响，也不引起凋亡。

In this work, it was found that MT at the concentrations of 〓 and 〓 mol·〓 could enhance the proliferation in rats and mice thymic lympho- cytes and human PBL as well as enhancing the proliferation in AA rats, 11 months mice and Mor-dependent mice thymic lym- phocytes, and RA patients PBL, and what was more that MT at a lower concontrations had a marked up-regulation on the above decreased lymphocytes proliferation.

结果表明，依赖组小鼠痛阈下降，跳跃次数增加，肛温降低，伴有胸腺细胞增殖能力的低下，Mor依赖小鼠的脑和血浆甲硫氨酸脑啡肽亦明显降低。ig MT（30、90 mg·〓×7d）能明显提高依赖性小鼠的痛阈，减少跳跃次数，恢复其肛温，阻止Mor对淋巴细胞功能的抑制，并能维持脑、血浆Met-Enk接近正常对照水平。

It is the interesting fact reported by Varas and colleagues that interleukin-7 (IL-7) influences the development of thymic dendritic cells.

我们注意到1998年Varas等报道IL-7能诱导胸腺细胞产生树突状细胞。

AIM: To investigate the effect of exogenous nucleotides on the repair of damaged DNA in mouse thymocytes in vitro.

目的：探讨外源核苷酸对受损小鼠胸腺细胞DNA修复的影响。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。