胸腺瘤

To date,it has been documented after transfusion of unirradiated blood components to at least 87 patients:in patients with severe combined immunodeficiency,thymic hypoplasia,and Wiskott Aldrich syndrome premature newborns and those with erythroblastosis fetalis; patients with hematologic malignancies including Hodgkin\'s and non-Hodgkin\'s lymphomas,acute myelocytic and lymphoblastic leukemias,chronic lymphocytic leukemia,and aplastic patients with solid tumors including neuroblastomas, glioblastoma,rhabdomyosarcoma,cervical carcinoma,small cell lung cancer,and germ cell tumor;patients after cardiac surgery and cholecystectomp-60;and in an apparently healthy 22-year-old woman.

目前为止，输注未辐照血液成分后，至少引起了87例TA-GVHD的发生，主要见于以下病人：严重的免疫缺陷病人、胸腺发育不全、Wiskott Aldrich综合症、早产儿、胎儿红细胞增多症、何杰金与非何杰金氏淋巴瘤等恶性血液病人、急性粒细胞性和淋巴细胞性白血病、慢性淋巴细胞性白血病、成神经细胞瘤等实体瘤病人、横纹肌赘瘤、宫劲癌、小细胞肺癌、微细胞瘤、心脏和胆囊手术病人。

Methods: Mice bearing in vivo transplanted tumor-H22 hepatic carcinoma were used to evaluate the drug"s activity of anti-tumor and GAPSGF"s efficacy enhancing effect by calculating the ratio of antitumor and q. HE dyeing was applied to observe the tumor"s morphological changes after the anti - tumor drug. It is observed the change of theperipheral white blood cells in serum and the body weight to analyze the GAPSGF"s toxicity reducing effect on the anti - tumor drug-Cytoxan. Applying ELISA method to observe the change of IL-2 in serum ,Applying carbon clearance method to test the function of uninuclear phagocyte,took the weight of the spleen and thoracic gland, analyzed the mechanism — efficacy enhancing and toxicity reducing of GAPSGF.

构建体内动物移植性H_(22)肝癌模型，通过计算抑瘤率与q值来分析药物的体内抗肿瘤活性，判断树舌多糖GF注射液的增效作用；采用瘤组织常规HE染色观察药物作用下的肿瘤细胞形态变化；观察外周血WBC数和体重改变来分析树舌多糖GF注射液对环磷酰胺抗肿瘤的减毒作用；采用ELISA法测定血清IL-2、小鼠碳粒廓清法测定单核吞噬细胞功能、取胸腺与脾脏称重测定脏器指数等以分析树舌多糖GF注射液增效减毒的作用机制。

Compared with control,①the mean tumor weight of H22 of SXKA Granules three dose groups were decreased significantly(P.01,P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 30%;②the mean tumor weight of S180 of SXKA Granules three dose groups were decreased significantly(P.01),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;③the mean tumor weight of EAC of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20 g/kg dose groups were above 38%;④the mean tumor weight of Lewis carcinoma of SXKA Granules three dose groups were decreased significantly(P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10、5 g/kg dose groups were above 36%;⑤the mean tumor weight of W256 of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;⑵Compared with control,SXKA Granules 20、10 g/kg dose groups had extended the survial time of the P388-bearing mice respectively(P.01),and the mean prolong rates of SXKA Granules 20、10 g/kg dose groups were above 50%;⑶Compared with S180-bearing group, SXKA Granules 20、10 g/kg dose groups could increase the weight of thymus and spleen, Spleen index and thymus index were increased, SXKA Granules 5 g/kg dose group could increase thymus index(P.05);⑷As Compared with control group, SXKA Granules 20、10 g/kg dose groups could improve mouse serum half hemolysis value depressed by transplanted tumor dramatically(P.01), which revealed the SXKA granules could improve the mouse humoral immunity system;⑸SXKA Granules 20 g/kg dose group could increase of englobe indexαon S180-bearing mice remarkably(P.01), which indicated the SXKA Granules could improve their cellular immunity system.

对荷W256大鼠，生兴克癌冲剂20、10、5 g / kg三组的平均瘤重明显低于对照组(P.01，P.05)，生兴克癌冲剂20、10 g / kg组的平均肿瘤抑制率均大于32 %；⑵与空白对照组相比，生兴克癌冲剂20、10 g/ kg能显著地延长移植小鼠白血病P388小鼠的存活天数(P.01)，生兴克癌冲剂20、10 g/ kg对荷白血病P388小鼠生命延长率均在50%以上；⑶与S180荷瘤组相比，生兴克癌冲剂对荷瘤鼠的免疫器官重量、胸腺指数和脾指数有一定的提高趋势，其中生兴克癌冲剂5 g / kg组对荷瘤小鼠的胸腺指数有一定的提高作用(P.05)；⑷与S180荷瘤组相比，生兴克癌冲剂20、10 g /kg组可提高由荷瘤引起的小鼠血清半数溶血素值的降低(P.01)，表明其可提高荷瘤小鼠体液免疫功能；⑸与对照组相比，生兴克癌冲剂20 g /kg组可提高荷S180肉瘤小鼠的免疫吞噬系数α值(P.01)，表明其可提高荷瘤小鼠细胞免疫功能。

MethodsThe transplanted tumor model of the mouse S180 sarcoma was established.Fifty mice were randomly divided into five groups,the control group,the CTX group,the Gecko group.They were treated respectively with oral administration of saline,and intraperitoneal injection of CTX 100 mg/kg only one time,oral administration of Gecko in doses of 13.5,9,4.5 g/kg,one time a day.After 14 days,the anti-tumor activity was evaluated by tumor tissue weighing. The impact on immune organ was detected by accounting thymus index, spleen index and the number of peritoneal macrophage which phagocytose chicken red blood cells.The protein express of vascular endothelin growth factor and basic fibroblast growth factor were detected by SABC immunohistochemistry.

方法建立移植瘤小鼠S180肉瘤模型，将50只雌鼠随机分为对照组、环磷酰胺组、壁虎高组、中组、低组共5组，分别给于生理盐水灌胃1次/d，CTX（100 mg/kg）腹腔注射1次，壁虎高、中、低组（13.5，9，4.5 g/kg），每天灌胃1次。14 d后，称取荷瘤小鼠瘤重、胸腺重、脾脏重，计算抑瘤率、胸腺指数、脾脏指数，观察腹腔巨噬细胞吞噬鸡血红细胞实验指标；用SABC免疫组化法检测血管内皮生长因子、碱性成纤维细胞生长因子的蛋白表达，TUNEL方法检测细胞凋亡率。

Objective: To investigate the relationship among the latest WHO classification of thymoma,myasthenia gravis and clinical stages.

目的探讨胸腺瘤最新WHO病理分型与重症肌无力及临床分期之间的关系。

To evaluate the X-ray and CT diagnostic value of Thymoma.

目的：评价X线平片、CT对胸腺瘤的诊断价值。

Ectopic thymoma is rare, especially when it arises in the pleural cavity.

异位性胸腺瘤是罕见的肿瘤，特别是源自於肋膜腔。

Methods:The MRI findings of 30 cases with surgery and pathology proved thymoma were retrospectively analyzed and correlated with histopathology patterns.

对我院30例经手术及病理证实的胸腺瘤的MR影像特征及其相应的病理学分型作对照回顾性分析。

We found a thymoma.

我们发现了一个胸腺瘤

The tumor-bearing mice received corresponding treatments for 15 consecutive days, after which their thymuses and spleens were isolated and weighed to calculate the thymus and spleen indices. The tumor mass was also weighed and the tumor inhibition rate calculated.

连续用药15d。第15天处死小鼠，计算胸腺指数、脾指数；剥离瘤块称重并计算抑瘤率；用免疫组织化学方法检测各组荷瘤小鼠肿瘤组织的增殖细胞核抗原的表达强度。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。