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Result:It was found that Polygala fallax Hemsl obviously increased the avoirdupois and thymus gland index of the mice.

结果:黄花倒水莲提取物能显著增加小鼠的体重和显著增加小鼠胸腺重量及胸腺指数。

The thymus is part of the immune system and is a tissue situated in the middle of the chest, behind the breastbone.

胸腺是免疫系统的一部分而且是处于胸腺中间的组织位于,胸骨的后面。

The study of mechanism of its anti-inflammationThis experiment shows that NTL can inhibit the edema of hind paw induced by fresh egg white in adrenalectomized rat, reduce the weight of thymus in rat, increase the content of hepatic glycogen ,but decrease eosinophil of mice through experimentalstudy of effect of NTL on edema of hind paw induced by fresh eggwhite in adrenalectomized rat, weight of thymus in rat, content ofhepatic glycogen and eosinophil of mice. The results indicate that NTL has the analogous function to cortin.

抗炎机理研究通过虎斑游蛇对去肾上腺大鼠蛋清性足跖肿胀、对大鼠胸腺重量和对小鼠肝糖原含量及对小鼠嗜酸性粒细胞数量影响的实验研究,表明虎斑游蛇能够抑制去肾上腺大鼠蛋清性足跖肿胀,使小鼠胸腺的重量减轻,增加小鼠肝糖原的含量而减少嗜酸性粒细胞的数量,提示虎斑游蛇具有肾上腺皮质激素样作用。

The studies on the capacities of immune responses of lymphocytes in peripheral blood and immune organs of Grass Carp (Ctenpharyngoden idellus Cuvier et Valencinnes) to PHA and SPA with incorporation of 〓H-TdR and active reaction of Acid α-Naphthyl Acetate Esterase indicated that there were T and B lymphocytes in peripheral blood of grass carp, but only T lymphocyte and no B lymphocyte in the thymus of grass carp. It was justified that the T lymphocytes in peripheral blood was originated from the thymus, and B lymphocyte could be from the spleen and anterior kidney of grass carp.

运用〓H-TdR掺入法和酸性醋酸萘酯酶活性检测法分别研究了草鱼外周血以及免疫器官中的淋巴细胞对PHA和SPA的免疫应答以及化学标志特征,发现草鱼外周血中存在着类似于哺乳动物的T、B两类不同的淋巴细胞亚群;同时也发现胸腺中只有T淋巴细胞,而无B淋巴细胞,提示了胸腺中淋巴细胞可能是外周血中T细胞的来源,而B淋巴细胞可能来自脾脏或前肾。

After 10 days, 20 days and 30 days for grass carp (Ctenpharyngoden idellus Cuvier et Valencinnes) immunized by being injected Aeromonas hydrophilia, the ANAE (acid α-naphthyl acetate esterase) positive cells ratioes increased, and the same time it was found that the ACP activity increased up too, it showed that the fish bodies were being at immune responding situation and their immnue activities enhanced.

通过对草鱼免疫器官的六种同工酶的分析发现:LDH在血浆、血液细胞、脾脏和胸腺中都表达为5条区带,前肾还额外显示出X酶带,血浆只有3条酶带;ADH除了胸腺为一条带以外,其它的均为3条酶带;MDH和3-GPDH在这些组织中均表达为3条酶带;EST在前肾中为7条酶带,其余的都为6条酶带;POX只在前肾和脾脏中表达为2条酶带。

Objective To study the morphologic changes with age in thymocytes and to explore the effect of luteolin on the aging changes in thymocyte morphology,immunity and anti-oxidation activity in aged mice.

目的 探讨不同年龄胸腺细胞在胸腺内区域性分布的形态学变化,研究木犀草素对衰老大鼠胸腺形态学及免疫功能和抗氧化能力的影响。

The results showed : thymus, Bursa, Harderian gland and spleen weight increase with age, gradually increasing; Thymus index, Bursa index and Harderian gland, the index increased with age gradually and the spleen index increase with age in the first increased and then decreased.

结果表明:胸腺、法氏囊、哈德氏腺和脾脏的重量随日龄的增长,逐渐增大;胸腺指数、法氏囊指数和哈德氏腺指数随日龄的增长逐渐变小,脾脏指数随日龄的增长,先增加后减小。

The results were as follows: Compared with control group, the weight and the relative weight of thymuses, bursas of Fabricius and spleens of experiment group increased significantly(P<0.05) or extremely significantly(P<0.01). In experiment group, the cortex of thymic lobule, bursa nodule and Periarterial Lymphatic Sheaths thicken obviously; the volume of bursa nodule, splenic nodule and ellipsoid augmented, and the germinal center of splenic nodule were obvious; the thymic corpuscle increased; the plica of bursas of Fabricius developed well and the degenerating of it retarded.

结果表明:试验组鸡胸腺、腔上囊、脾的重量和器官指数均高于对照组,差异显著(P<0.05)或极显著(P<0.01);试验组的胸腺小叶皮质增厚,胸腺小体增多;腔上囊皱襞发达,腔上囊小结体积大,皮质较厚,退化延缓;脾的动脉周围淋巴鞘增厚,脾小结体积大,生发中心明显,椭球增大。

The result indicated different expression of CD3,CD4,CD8 on large thymocytes and small thymocytes.

结果表明,胸腺中大胸腺细胞和小胸腺细胞的CD3、CD4及CD8的表达不同,在大胸腺细胞中,CD3的表达比小胸腺细胞的CD3 表达要高出10个百分点。

To study the effects on the body of animals after incorporation of 3H-TdR and its mechanism, the laws of distribution A retention and absorbed dose in blood , thymus, spleen, femur, heart, lung,kidney, liver, brain , spermary , small intestine and muscle were detected by liquid scintillation counter after 3H-TdR was injected into the tail vein of mouse; the process of dynamic incorporation of in the lymphocytic cell nucleus of blood , thymus , spleen and the nucleus of femur was monitored; the absorbed dose in the cell nucleus was estimated; the influence to RNA"s synthesizing and cell"s survival was observed using the technology of CLSM; A segment of Egr-1 gene was cloned with reverse transcriptase- polymerase chained reaction, the influence to the expression of Egr-1 gene in the spleen cells was observed.

为了探讨有机结合氚内污染对生物机体的影响及其作用机理,本课题应用均相液体闪烁测量技术研究了氚标记胸腺嘧啶核苷(~3H-TdR)经尾静脉注入小鼠机体后,在血液、脑、胸腺、心脏、肺脏、肝脏、脾脏、肾脏、小肠、睾丸、肌肉和股骨共12种组织器官的生物动力学分布规律及其吸收剂量;应用纸片法液体闪烁测量技术研究了~3H-TdR内污染在外周血、胸腺和脾脏淋巴细胞及骨髓细胞的动态滞留规律,估算了细胞核的吸收剂量;应用共聚焦显微镜观察了~3H-TdR内污染对脾细胞核酸合成及其存活率的作用,应用反转录PCR技术研究了~3H-TdR内污染对脾细胞早期生长反应基因-1(Egr-1)转录表达的影响。

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