胶骨

Bone defects around implants were repaired by guided bone regeneration technique with BME-10X medical collagen membrane and Heal-all oral biofilm respectively.

选择种植术区存在骨缺损的患者72例，均为单颗牙缺失，按随机原则分为对照组和试验组，分别采用博特医用胶原膜和海奥口腔修复膜行"引导性骨再生"技术修复骨缺损。

Effects of Adv-hBMP2 gene modify on the bone formation of tissue-engineered bone substitute. BMSCs of canine transferred by Adv-BMP2 gene expressed ALP in vitro and induced ectopic bone formation in nude mice. BMSCs adhered on the surface of FDB after 4hrs, expanded in 24hrs and proliferated in polylayer in 4d. FDB, combined with BMSCs transferred by Adv-BMP2 gene, induced bone formation in the subcutis of nude mice in 6 weeks.

结果：1.BMP-2基因修饰对组织工程化骨成骨的影响 BMSCs经Adv-BMP2基因转染后ALP染色强阳性、并在裸鼠肌肉形成异位骨组织；转基因的BMSCs与冻干骨复合后24小时即完全贴附生长，4天后复层生长并分泌大量胶原，植入裸鼠背部皮下6周后可见大量成骨，很少吸收，而单纯冻干骨或冻干骨复合BMSCs基本不成骨。2。

aim: to evaluate the feasibility of injectable calcium phosphate cement and fibrin sealant as an injectable compound carrier of bone morphogenic protein .

目的： 了解以注射型磷酸钙骨水泥/纤维蛋白胶共同作为骨形态发生蛋白复合载体的注射型骨修复材料在小鼠体内异位成骨的能力，探讨其作为注射性骨替代物的可行性。

The compound of bioglass and bone morphogenic protein possesses much high inductive potentialties and the ability of rebuiding bone defect and can serve as an autograaft substitute material and had an great foreground in clinical trials.

溶胶凝胶生物活性玻璃复合骨形成蛋白人工骨具有高效的诱导成骨能力和良好的生物降解性，可成功的修复大段的骨缺损，是一种骨缺损修复的良好的生物材料，有着广阔的临床应用前景。

Methods BMSCs isolated from rabbit iliac bone marrow were culture-expanded in vitro. The injectable tissue-engineered bone constructed from autologous PRP, FG, and BMSCs was cultured in vitro, and its biological characteristics were observed including the time of gel formation, histological features, seed cell survival and microscopic structures. Results The constructed injectable tissue-engineered bone began gel formation within 20 to 30 s, and after a week-long culture, the gelatine began to degrade, and numerous well viable fusiform cells could be seen to adhere to the bottom of the Petil dish, Scanning electron microscopy identified globular and olivary cells embedded in the fibrin glue, and numerous small particles could be seen around of the cells.

从兔髂骨处抽取骨髓体外培养BMSCs并诱导向成骨细胞分化，抽取兔自体动脉血提取PRP，以FG、BMSCs、PRP共同构建可注射型组织下程骨并体外培养观察其生物学特性如凝胶形成时间，组织学特点、细胞存活情况及其超微结构特征等结果构建的可注射型组织工程骨可在短时间内形成凝胶，体外培养1周时其中细胞生长良好，电镜下见纤维蛋白网格结构致密，种子细胞及血小板颗粒分布广泛。

In order to observe the capacity of composite artificial bone made from collage/Nano tricalcium phosphate conducting subperiosteal bone formation and investigate the possibility applied in reconstruction of astrophy aveolar ridge, the composite artificial bone was implanted into subperiosteum of the cranial bone in rabbits.

将胶原与纳米磷酸三钙复合制成复合人工骨并植入兔颅骨的骨膜下作为实验组，使用显微镜测微尺测量不同时间点新骨自骨表面长入材料内的高度，并和羟基磷灰石组作对照，观察 Co/N- TCP复合人工骨引导成骨能力，探讨其用于萎缩性牙槽嵴重建的可行性。

MATERIALS: Fibrin glue was made by a certain ratio of fibrinogen and thrombin; bovine cancellous bone following defatting and deproteinization was mixed with fibrin glue to establish composite scaffold.

材料：纤维蛋白原与凝血酶按比例制备纤维蛋白胶，牛松质骨经去脂去蛋白等无机化处理后与纤维蛋白胶复合，制成复合骨支架材料。

In the period of 8 to 16 weeks after operation,new bone was formed continuously, artificial bone gradually reconstructed to mature lamellar bone,bone trabeculae and medullary cavity,etc. Conclusion The preparation of CPC is simple.

结果 CPC植入后4周有新生软骨形成及未成熟的骨组织，可见大量的软骨细胞、成骨细胞、胶原组织及较多的小血管。8～16周新骨继续生成，人工骨逐渐改建为成熟的板层骨、骨小梁和髓腔结构。

Results There existed new cartilage and new immature bone tissue in the bone substitute in 4 weeks after operation, as well as mass of cartilageous cells,osteoblasts, collagen tissue and more small vessels were seen. In the period of 8 to 16 weeks after operation,new bone was formed continuously, artificial bone gradually reconstructed to mature lamellar bone,bone trabeculae and medullary cavity,etc.

结果 CPC植入后4周有新生软骨形成及未成熟的骨组织，可见大量的软骨细胞、成骨细胞、胶原组织及较多的小血管。8～16周新骨继续生成，人工骨逐渐改建为成熟的板层骨、骨小梁和髓腔结构。

Changes of liposome encapsulated psoralen and release rate were detected during a 3 week storage at 4 ℃ for evaluating the stability of the liposomal formulation.

以同浓度的补骨脂素凝胶为对照，用透析法检测补骨脂素脂质体凝胶的体外释药模式，并对其在4 ℃下贮存3周的释药稳定性进行研究。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。