胶质细胞瘤

Results MRI findings of central neurocytoma are specific in 5 cases. The ganglioglioma was found in the tempora and occipital lobe in 7 cases,in the brainstem in 1 case, cystic-solid tumor was observed in 5 cases with extramural nodule in 3 cases, obviously thickened gyri were revealed in 1 cases and central necrosis in 2 cases.The 3 cases of Lhermitte-Duclos disease include the specific molecular layer imaging features.

结果 5例中枢神经细胞瘤有一定的MRI特征，3例诊断正确。8例神经节细胞胶质瘤中，7例位于或主要位于颞、枕叶，1例位于桥脑和延髓，表现为囊实性者5例，实性部分位于囊外的有3例，呈实性表现为局部脑回增厚者1例，囊变坏死明显者2例。3例小脑发育不良性节细胞瘤有特征性的条纹状或分层状表现。

Transduction of TNF-α gene into TIL of human glioma by retroviral vectors and study of its biological activity in vitro. The development of retroviral vectors for TNF-α gene transfer and preparation of carrier cells-TIL have al- lowed transducing marked gene NeoR and purpose gene TNF-α into TIL cells respectively by use of monoclone tilter virus PLC-2 and PLJC-5. Detect the proliferation of TIL, expression of TNF-α and the anti-tumor activity of glio- ma TJ8510 cells in vitro.

在TNF-α逆转录病毒转移系统的建立及运载细胞TIL制备的基础上，利用构建的单克隆高滴度病毒细胞株PLC-2和PLJC-5将标记基因NcoR和目的基因TNF-α分别导入到TIL细胞中；对TNF-α基因转导后的TIL细胞进行细胞的增殖情况、TNF-α表达水平及对人脑胶质瘤TJ8510细胞的体外抗瘤活性的检测。

Therefore, our data show that in cases when clear cell chondrosarcoma and chondroblastoma pose a diagnostic challenge, the presence of type II collagen in the extracellular tumour matrix significantly supports the diagnosis of clear cell chondrosarcoma and aids in distinguishing it from chondroblastoma.

我们的数据表明，在诊断透明细胞软骨肉瘤和成软骨细胞瘤受阻时，细胞外肿瘤基质中II型胶原的存在对于诊断透明细胞软骨肉瘤相当有帮助，并有助于和成软骨细胞瘤间的鉴别。

Results Lactacystin dealed with C6 glioma cells in 24 h, kytoplasm was concentrated and anachomasised, the chromatin of nucleus was concentrated pyknoticly to see under photo-microscope. The microvilli on surface dispeared、nucleus crenated、chromatin aggregated pyknoticly under transmission electron microscope respectively.

结果 Lactacystin处理体外C6胶质瘤细胞24 h后，光镜下见胞浆浓缩深染，胞核染色质致密浓缩，透射电镜下见细胞表面微绒毛消失，核皱缩，染色质致密浓缩、边集。

Finally, when the gliomatous component is very bland and I cannot decide, I would just diagnose it as a grade I~II ganglioglioma.

最后，如果胶质瘤成分細胞分化非常好时，我不能判定Ⅰ或Ⅱ级，就诊断为Ⅰ-Ⅱ级节细胞胶质瘤。

Fig.3 The astrocytes in the area of gliosis around the anaplastic astrocytoma displayed Fas expression.

在多形性胶质母细胞瘤中内增生的血管内皮旦Fas强阳性，瘤细胞变为Fas阳性

Tumor mass could express CD133 and nestin. The karyoplasmic ratio of CD133+ brain glioma stem cells reached 2/3-3/4, and there were a few processes, a few organelles and a plenty of ribosome. These were accorded with the characteristics of stem cells.

肿瘤球能同时表达干细胞标志物CD133和巢蛋白，CD133+脑胶质瘤干细胞核浆比例达2/3~3/4，突起少，胞浆中线粒体等细胞器较少，核糖体丰富，未见胶质丝等分化结构，符合干细胞超微结构特点。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

The level of β-tp was in direct proportional to the proliferation of cell in the oligodendroglioma cell lines (SHG-44, U-251, BT-325), but not in the non-oligodendroglioma cell lines (oophroma, prostate-carcinoma and neuro-oocyte).

但在非胶质瘤细胞株，如卵巢癌细胞，神经母细胞瘤细胞及前列腺癌细胞株等，β-tp的浓度与细胞增殖的趋势相反。

After treatment with the conditional medium of tumor cells, the number of tubules increased in a dose-dependent manner.

结果：血管生成素-2在神经胶质瘤细胞中的表达强度与瘤组织的分级呈正相关(p.05)；肿瘤细胞诱导肿瘤血管形成呈浓度依赖效应（p.05）。

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是，在否定句或疑问句里，这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷