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胶质细胞

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Astrocyte is the most glial cell in the central nervous system.

星形胶质细胞(astrocyte,Ast)是中枢神经系统内最多的胶质细胞

MAIN OUTCOME MEASURE: The changes of the morphologic hippocampal pyramidal cell and GFAP expression of astrocyte.

主要观察指标:观察海马锥体细胞形态学变化及星形胶质细胞胶质纤维酸性蛋白表达的变化。

Results By using optical microscope, the neurocytes of hippocampus in experimental group were observed to denaturalize, tumefy, destroy and disappear.

点燃癫痫鼠海马区损伤越重,胶质细胞GFAP免疫反应性越强,通过检测GFAP可以推测星形胶质细胞与癫痫后脑损伤的程度。

Objective To explore the role of microglia and astrocytes in the pathogenesis and lesion progress in experimental autoimmune encephalomyelitis.

目的 确定小胶质细胞和星形胶质细胞在实验性自身免疫性脑脊髓炎发病及病变发展中的作用。

Expression of islet-1 in spinal cord of adult rat.In grey of the spinal cord of adult rat, the results of both of ISL1 immunohistochemistry and islet-1 mRNA in situ hybridi-zation showed that islet-1 gene expressed predominantly in the nuclei of motoneurons in ventral region and some cell around central canal and dorsal region. In white of spinal cord, the expression of islet-1 located in astroglia in anterior and dorsal funiculus.

在正常成年大鼠脊髓灰质中,ISL-l免疫组化和islet-lmRNA原位分子杂交结果都显示islet-1在腹侧角运动神经元中有相当强度的表达;在中央管周围和背侧角胶状质也有islet-1阳性表达细胞存在;在脊髓白质中,islet-l在腹侧索和背侧索中的星形胶质细胞有表达,外侧索相对较少。

AIM: To culture astrocytes from human donor eyes in order to understand the function of astrocytes in remodelling events in the glaucomatous optic nerve head.

目的:探索人眼视神经乳头星形胶质细胞体外培养的方法,为进一步研究星形胶质细胞在青光眼性视神经病变中的作用打下基础。

Objective To investigate the response of neurons and astrocytesfrom Sprague Dawley rat brain against tert-buty1 hydroperoxide toxicity,both separately and in cooperation, for the purpose of exploring the interrelation of the two kinds of cells.

目的研究混合培养脑神经元与星形神经胶质细胞对活性氧叔丁基脂氢过氧化物的应激性,以探讨神经元与星形神经胶质细胞的相互作用。

PARTⅡCharacteristic of MMP-9 Activation in Microglia and itsCytokines Secretion after HSV-1 infectedObjective: To investigate the characteristic of MMP-9 activation in microglia and itscytokines secretion.Methods: Balb/c mice were injected intracerebrally with herpes simplex virus type 1(HSV-1) to form herpes simplex encephalitis.

第二部分HSV-1感染小胶质细胞后MMP-9及炎性因子分泌特点研究目的:研究单纯疱疹病毒(HSV-1)感染小胶质细胞系BV2后炎性因子的表达特点,探讨BV2细胞可否作为小鼠单纯疱疹病毒性脑炎模型的替代研究对象。

IL-1 is elevated in tissue homogenates of temporal lobe and in cerebrospinal fluid from patients with AD. In Alzheimer patients activated immunoreactive IL-1+microglia are increased sixfold over those presenting in age matched controls and the activated IL-1+ microglia are involved in the evolution of diffuse plaque to the diagnostic neuritic plaque. IL-1 is produced by astrocytes and microglia which are components of senile plaques and induced astroglia proliferation.

AD患者颞叶脑组织及脑脊液中发现IL-1含量增高,并且IL-1免疫反应阳性的小胶质细胞比同龄的对照组高6倍,IL-1免疫反应阳性的小胶质细胞与弥散性淀粉样沉淀斑块发展成为具有诊断意义的神经纤维斑块有关。

Astrocytes constitute nearly half of the cell in brain, but its funtion is a long-standing neurobiological mystery.

星形胶质细胞是脑内数量最多的一类胶质细胞,与神经系统生长发育,功能活动及疾病的形成有密切关系。

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