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胶质细胞

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Alternative etiologies for the development of this disorder include intrauterine insult (ischemic, metabolic, or viral such as CMV) during the 12th to 24th week of embryologic development. This results in damage to the germinal matrix and radial glial cells. Radial glial cells act as mechanical guides by which neurons are transported to the outer cortex during development.

另一种病因可能是由于第12-24周期间的宫内损伤(缺血、代谢异常、或病毒感染如CMV),其结果导致生发基质和放射状胶质细胞的损伤,在神经元移行至外皮层的过程中,放射状胶质细胞充当着机械性向导的作用。

Northern blot revealed that DAT is expressed weaklt but specificlly in the brain tissue, and in situ hybridization DAT is restrictedly expressed in the adult brain tissues including substantia nigra and striatum, suggesting an important function in the dopaminergic system.

利用cRNA探针的原位杂交组织化学研究,发现DRP在成年大鼠脑组织神经元和胶质细胞均有表达,以胶质细胞广泛表达是其重要特征;而DAT在成年脑组织仅限于少部分核团的有限表达,包括黑质和纹状体。

Results:Expression of elastase mRNA has been found in the endothelial cells,the medial smooth muscle cells and the adventitial fibroblasts of the abdominal aorta,the lymphocytes,monocytes in blood,the tracheal hyaline cartilaginous cells,the glandular cells of the pancreas,the epithelial cells of the parotid gland and submaxillary gland,the hepatoeytes,the endothelial cells of the liver sinusoid wall,the goblet cells of the mucous membrane of the small intestine,the cardiac myocytes,the renal interstitial fibroblasts,the alveolar epithelial cells,the cerebral glial cells,the fibroblasts of the dermis oorium of the skin,the primary spermaocytes,the secondary spermaocytes and sperm in the seminfferous tubule of the testis,the lymphocytes in the spleen and thymus.

结果正常大鼠腹主动脉的内皮细胞、中膜平滑肌细胞以及血管外膜成纤维细胞,血液细胞中的淋巴细胞、单核细胞,气管透明软骨细胞,胰腺的腺细胞、腮腺、颔下腺上皮细胞,肝细胞、肝窦壁的内皮细胞,小肠黏膜杯状细胞,心肌细胞,肾间质的纤维母细胞,肺泡上皮细胞,大脑胶质细胞,皮肤真皮纤维母细胞,睾丸曲精细管内的初级精母细胞、次级精母细胞以及精子,脾脏以及胸腺的淋巴细胞等,均有弹力蛋白酶mRNA的表达。

To determine that the relationship between alteration of cell cycle of astroglia and formation of the epileptic condition.

第四部分通过对在致痫时星形胶质细胞细胞周期的研究,来探讨星形胶质细胞在癫痫形成中的作用机制。

MTT assay and morphological observation were used to evaluate the toxicity of rotenone on astroglia,cell proliferation and the expression of CX43 mRNA were detected by growth curve analysis and RTPCR.

观察染毒星型胶质细胞形态,检测细胞活力,通过生长曲线分析鱼藤酮对星型胶质细胞增殖的影响以及RTPCR检测缝隙连接蛋白(connexin43,CX43)mRNA表达。

MTT assay arid morphological observation were used to evaluate the toxicity of rotenone on astroglia, cell proliferation and the expression of CX43 mRNA were detected by growth curve analysis and RT-PCR.

观察染毒星型胶质细胞形态,检测细胞活力,通过生长曲线分析鱼藤酮对星型胶质细胞增殖的影响以及RT-PCR检测缝隙连接蛋白(connexin43, CX43)mRNA表达。

This experiment further investigated the possibility of differentiation of BMSCs in rats into neural stem cells in vitro, and into neural cells and neuroepithelial cells, so as to provide seed cells for cell transplantation of nervous system disease.

目的:已证实骨髓基质细胞可分化为中胚层组织细胞,实验予进一步探讨体外分离培养的骨髓基质细胞向神经干细胞分化的可能性,以及是否能继续定向分化为神经细胞及神经胶质细胞,为神经系统疾病细胞移植治疗提供种子细胞。

I think WHO grade I dysembryoplastic neuroepithelial tumor is the most likely diagnosis, but one would like to see isolated floating neurons in the microcysts in addition to the small oligodendrocyte-like cells and neuropil-like fibrillary matrix.

我考虑可能是WHOI级的DNT(胚胎发育障碍的神经上皮肿瘤)。但DNT中除了少突胶质细胞样的小细胞和神经毡样胶质纤维基质外,还应该见到微囊中漂浮的神经元。

RESULTS: The neural stem cells isolated from neonatal rat brains had the potential of serial passage and proliferation, besides, they express neuroepithelial stem cell protein and differentiate into neurons, astrocytes and oligodendrocytes.

诱导分化后的细胞能表达神经元细胞、星形胶质细胞、少突胶质细胞的特异性蛋白。

GFAP overexpessed but NOS neuron decreased, distorted and pale. The glia in SM-DB complex of ONR hypertrophied, but NOS neuron no degeneration. The increased GFAP immunoreactivity and the morphometric and cytological changes in SM-DB complex astrocytes may reflect a sustained upregulation of cellular activity with the insults of neurons, resulting in hypertrophy of glial perikarya and cell processes.

老年减退组星形胶质细胞的细胞体密度较老年正常组和青年组明显增加(P 在GFAP免疫细胞化学和NOS组织化学双重染色的切片上,老年减退大鼠SM-DB星形胶质细胞明显肥大,突起粗壮弯曲,GFAP超量表达,而NOS阳性神经元数量减少,胞体变形,突起减少,染色深度下降。

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