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胶质细胞

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Nowadays, as more and more attention are paid to glia, which is considered to play an important role in epileptic pathogenesis,In this study, we chose fluoroacetate, a reversible neuroglia metabolic inhibitor as well as a rodenticide that can induce epileptic seizures, to set up a new epileptic animal model by acting on neuroglia to induce seizures.

目前常用的急性化学致痫模型其致痫机制均是作用于神经元,通过对CNS递质的作用来诱发癫痫。虽然,随着胶质细胞在癫痫的发病机制中的作用日益受到关注,但由于缺乏作用于胶质细胞的癫痫模型,使研究胶质细胞在癫痫发病机制中的作用及其与神经元的关系带来了障碍。

The growth speed of the cells with transfected Tob gene got slowly, even to a growth arrest.

结论Tob基因转染后的胶质瘤细胞生长受到明显抑制,出现向正常胶质细胞的分化和凋亡现象,提示Tob基因确实是一胶质瘤细胞增殖抑制基因,值得进一步做功能研究和实验性基因治疗研究。

Objective: To observe the quantitative and morphological changes of astrocytes in nucleus of solitary tract after vagus nerve stimulation.

目的:观察颈部迷走神经千刺激后孤束核内星形胶质细胞数量、形态的改变,同时在电镜水平观察星形胶质细胞与神经元之间突触形态、数量的变化,从胶质细胞的角度阐明VNS治疗神经精神疾病的重要机制。

Astroglia had an apprant change of cell cycle in epileptogenesis, which may be an important mechanism involing gliosis and even development of glial scar.

星形胶质细胞细胞周期的改变是引起星形胶质细胞过度增殖,产生胶质疤痕和形成癫痫的重要机制之一。

Results 1、The CD11b-positive microglia were dyed low brown with small bacilliform cell bodies,ramified morphology,thin and long protuberance in CON and NIC group;In LPS group,the CD11b-positive microglia were dyed chocolate brown with more big roundish cell bodies,thicker and shorter processes;Most CD11b-positive microglia were dyed brown with bacilliform cell bodies,ramified morphology and few cells were dyed deep brown with more big roundish cell bodies,thicker and shorter protuberance in NIC+LPS group.

结果 1、CON组与NIC组CD11b阳性小胶质细胞胞体小,呈杆状,突起细长,染成浅棕色:LPS组小鼠脑内CD11b阳性小胶质细胞胞体增大,呈圆形,突起粗而短,染成棕褐色;NIC+LPS组少量CD11b阳性小胶质细胞胞体增大,圆形,突起变粗变短,染成深棕色,多数呈杆状,突起少、细长,染成浅棕色。

Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mixed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mix ed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

In order to explore the function of glia in the progress the experiment was performed both in presence of glia and in the absence of glia The mouse mesencephalic cells were exposed with MPP+ with different concentration. Iloprost was used to investigate whether it can prevent dopamine neuron from the neurotoxic of MPP~..

为了观察胶质细胞在其中的作用,将细胞分为未抑制胶质细胞胶质细胞抑制组;将不同浓度的MPP~+加入体外培养的中脑多巴胺能神经元培养液中,并加入Iloprost来研究其对MPP~+所导致的神经毒作用是否有保护作用。

Neuroglial cells (oligodendrocytes and astrocytes) play a very important role in establishment and maintenance of normal neuronal functions and formation of neurological diseases.

神经胶质细胞(主要是少突胶质细胞和星形胶质细胞)对于正常神经系统功能的建立和维持及神经系统疾病的产生都起着至关重要的作用。传统观念认为大脑功能的唯一发挥者是神经元。

Objectives: To study the relationship between matrix metalloproteinases and their inhibitors and the invasion and metastasis of human glioma, as well as the relationship between the expression of MMP-2 and TIMP-2 in human primary and recrudescent glioma and the grade of malignancy.

目的:探讨基质金属蛋白酶类与胶质细胞瘤浸润性生长之间的关系及其在胶质瘤复发中的作用,以及基质金属蛋白酶及其抑制因子(MMP-2、TIMP-2)的阳性表达与胶质细胞瘤病理分级及预后的关系。

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