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胶质细胞

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Under transmission electron microscope, cellular swelling in brain tissue, nuclear membrane of neuron has incisures, some chromatic agglutination, group A mainly appears endoplasmic reticulum distention and glial cell endocytosis, while group B mainly appears histolysis; cardiac fibrous structure is chaotic, Z line concentrates, mitochondria swelling, nucleus deform; the ecphyma of podocyte becomes thinner and longer like villus, some mix together, plasma membrane infolding of renal cells decreases, mitochondria malformation, cells in lumens.

透射电镜观察显示,试验组动物脑组织细胞肿胀,神经元核膜出现切迹,部分染色质凝集,A组动物出现内质网扩张及胶质细胞吞噬现象,B组动物以组织溶解为主;心肌纤维结构紊乱,Z线聚集,收缩带形成,线粒体肿胀,核变形;肾小球足突细长,绒毛化,并可见足突融合,肾小管上皮细胞质膜内褶减少,线粒体畸形,管腔可见脱落细胞,上述改变均以B组为著。

Neural stem cells are operationally defined as mitotically competent, self-renewing, and multipotent cells able to differentiate along three main cell lineages in the early neurogenesis (i.e., neurons, astrocytes, and oligodendrocytes).

神经干细胞(neural stem cells,NSCs)广泛存在于胚胎脑组织中,也存在于成年哺乳动物的神经系统。NSCs具有自我更新能力,能够定向分化为神经元、星形胶质细胞和少突胶质细胞

BACKGROUND: Bone marrow mesenchymal stem cells can differentiate into osteoblasts, chondrocyte, sarcoblasts, adipocyte, neuroepithelial cells, as well as vascular endothelial cells under different conditions.

背景:骨髓间充质干细胞在不同条件下可以分别分化为成骨细胞、软骨细胞、成肌细胞、脂肪细胞、神经胶质细胞、血管内皮细胞等。

Results There was significant negative correlation between the Nogo-A expression and the morphological change of tumor tissues according to immunohistochemistry. Western-blot analysis also indicated that the gray value of Nogo-A protein band in the oligodendroglioma group was significantly higher than that in the anaplastic oligodendroglioma group.

结果 免疫组织化学结果显示,Nogo-A免疫阳性染色的光密度值与肿瘤细胞核分裂、核异型比例呈明显的负相关,对蛋白印迹试验结果进行光密度分析也发现少突胶质细胞瘤中的Nogo-A蛋白条带灰度值明显高于间变型少突胶质细胞瘤中的灰度值。

To study levels of beta-trace protein in the cerebrospinal fluid with oligodendroglioma patients and in the mediums of incubated rat oligodenderocyte.

蒋雨平 ,蔡振林,任惠民目的:探索神经胶质细胞及人脑胶质瘤细胞是否能分泌β-tp。

RESULTS:Immunogold particles for IRE1 could be identified in RGCs of the retin...

IRE1在RGC与少突胶质细胞内胶体金标记颗粒分布部位距离ER管腔距离增加为特征,在钳夹0.5d内神经干少突胶质细胞以及视网膜RGC内均表现非常明显的距离增加。

Results In contrast with enzymatic dissociation, the method of mechanical dissociation, breaking up great neurospheres into small spheres with gradually reduced pipette, had advantages of raising cell viability and shortening cell doubling time (P.05). After NSCs being cultured long term in vitro, the number of neurons generated decreased with passaging, whereas the number of astrocytes increased.

体外长期培养条件下,随着培养时间的延长,NSCs分化为神经元的比例逐渐降低,星形胶质细胞的比例逐渐增高;在4~12代NSCs分化为神经元的能力表现出下降的趋势,但仍较为稳定;12代后,神经元的分化比例迅速下降,星形胶质细胞的比例迅速上升。

On the other hand, previously differentiated neuron and astrocyte may also re-express nestin, which may indicate the recovery and plasticity of neuron and astrocyte.

另一方面,已分化的神经元和星形胶质细胞再表达胚胎期蛋白nestin,可能有利于神经元和星形胶质细胞修复。

NGF and BDNF reduced differentiation of NSCs into astrocytes, andincreased into oligodendrocytes in co-culture and two-chamber sharedmedium assay.

NGF或BDNF在不同的共培养体系中,可以起到减少神经干细胞向星形胶质细胞分化,增加少突胶质细胞分化的作用,而对神经元的分化没有影响。

GFAP+ astrocytes hhd no changes and there were no VIM+ astrocytes surrounding wounds in postmortem groups.

死后脑干损伤组GFAP+星形胶质细胞无改变,创缘及创周无VIM+星形胶质细胞出现。

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