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Rat in Group B was set an air bladder which was empty and not perfused water. Water of 0.6 ml, 0.8 ml, 1.0 ml, 1.2 ml, 1.4 ml and 1.5 ml was perfused respectively into the air bladders which were set in the colon of rats in group C, D, E, F, G and H. Then the changes of ethology of the rats were recorded in interval of an hour.

应用疼痛行为学的观察方法,观察1h各组动物的行为学改变,并采用免疫荧光化学的方法,观察大鼠DCN中神经元被激活的标志c-fos及胶质细胞的胶质原纤维酸性蛋白(glial fibrillary acidic protein, GFAP)和小胶质细胞特异性补体OX42的表达情况,空白对照组是在疼痛高峰点(1.2 ml)处死取材。

Methods The cells were divided into 5 treatment groups(10,25,50,75 and 100 μmol·L-1 QUE), blank control and menstruum control group. The rat C6 cells were cultivated to 1×106·mL-1 in the RPMI 1640 medium, then added into 96 holes board with various doses of QUE by 3 holes per group,and MTT assay was used to observe the proliferation of the cells treated for 24,48 and 72 h. The change of cell cycle was also observed by flow cytometry after the cells were treated with 50 and 100 μmol·L-1 QUE for 48 h. The changes of the protein P53 and Bcl-2 of C6 cells treated with 50 μmol·L-1 QUE for 48 h were detected by immunocytochemical methods.

按QUE浓度分成10、25、50、75及100 μmol·L-15个处理组和空白对照组及溶剂对照组,大鼠脑胶质瘤C6细胞在RPMI 1640培养基中生长达1×106·mL-1后,在96孔板中分别加入上述浓度的QUE继续培养,每组设3复孔,作用24、48及72 h,采用MTT比色法检测QUE对大鼠脑胶质瘤C6细胞的增殖抑制情况,流式细胞术对50及100 μmol·L-1的QUE作用48 h的大鼠脑胶质瘤C6细胞进行周期分析,免疫组化法检测50 μmol·L-1的QUE作用48 h 的p53和bcl-2基因产物。

Gliosis is resulted in TLE. The synapse consists of the presynaptic and postsynaptic terminals, which in many synapses are surrounded by glial cell.

颞叶癫痫可导致神经系统胶质增生,突触后终端与胶质细胞之间形成突触,突触后终端的树突棘的形态学的变化引起突触结构的改变,与胶质细胞之间形成的突触为异位突触,引起海马内环路性质的变化,从而提高致痫性。

At histopathologic analysis, neuronal tumors are usually classified as pure neuronal cell tumors (gangliocytoma, Lhermitte-Duclos disease , central neurocytoma) and mixed neuronal-glial tumors (ganglioglioma, desmoplastic infantile ganglioglioma, dysembryoplastic neuroepithelial tumor, ganglioneuroma).

根据组织病理学的分析,神经元肿瘤通常被分为:单纯的神经元细胞肿瘤(神经节细胞瘤,Lhermitte-Duclos 病〔发育不良性小脑神经节细胞〕瘤),中枢神经细胞瘤)和混合性的神经元-胶质肿瘤(神经节神经胶质瘤,成结缔组织性婴儿节细胞胶质瘤,胚胎发育不良性神经上皮瘤,神经节瘤)。

Neuroglial cells (oligodendrocytes and astrocytes) play a very important role in establishment and maintenance of normal neuronal functions and formation of neurological diseases.

神经胶质细胞(主要是少突胶质细胞和星形胶质细胞)对于正常神经系统功能的建立和维持及神经系统疾病的产生都起着至关重要的作用。传统观念认为大脑功能的唯一发挥者是神经元。

This pattern is characterized by the combination of pro-MMP-2 and membrane type 1 (MT1)-MMP expression, which drie pericellular generation of actie MMP-2 and local degradation of normal lier matrix. In addition there is a marked increase in expression of TIMP-1 leading to a more global inhibition of degradation of fibrillar lier collagens by interstitial collagenases (MMP-1/MMP-13). These pathways play a significant role in the progression of lier fibrosis.

其降解肝正常基质,同时抑制引起肝纤维化的纤维胶原降解,这种情况的特点是前明胶酶A合成和膜型1-MMP表达,使得小叶内细胞激活MMP-2和降解当处的正常肝基质,此外血浆1型组织基质金属蛋白酶抑制剂(TIMP-1)明显升高引起广泛的抑制间隙胶原酶(MMP-1/MMP-13)对纤维肝脏胶原的降解。

A case is made that areas of chronic demyelination arise because of concurrent loss of oligodendrocyte progenitor cells and oligodendrocytes and that because of the slow rate of repopulation that occurs in old individuals the recruited OPCs are not exposed to the acute inflammatory environment required to generate remyelinating oligodendrocytes.

一种说法是慢性脱髓鞘的区域产生系因少突胶质原始细胞和少突胶质细胞并存,而且因老年个体中缓慢的再生率,补充的OPCs没有暴露于产生髓鞘再生少突胶质细胞需要的急性炎症的环境。

By culturing human brain microvascular endothelial cells and glioma cells separatedly and simutaneously ,and then analyzing their pre- and post-cultune FasL levels, we study the effect of the grouth of glioma cells upon FasL level of human brain microvascular endothelial cells.

我们通过将人脑毛细血管内皮细胞与胶质瘤细胞分别培养及共同培养,对培养前后人脑毛细血管内皮细胞与胶质瘤细胞FasL表达水平的分析,来探讨胶质瘤细胞的生长对人脑毛细血管内皮细胞FasL表达的影响。

Reconstruct ion of interstitial collagen in sinuatrial node occur since the rat diabetes has been duplicated for 16 weeks. The unbalance between collagen type Ⅰ and type Ⅲ in sinuatrial node of diabetes rat can be reversed by insulin treatment.

Ⅱ型糖尿病大鼠窦房结16周后出现间质胶原重构,胶原类型比例失衡;Ⅱ型糖尿病大鼠行胰岛素降低血糖后可不同程度下调窦房结间质的沉积,一定程度上逆转胶原类型比例紊乱。

Results: We found that carbachol decreased the number of microglia even in the presence of GM-CSF in dose-dependent manner, with the most effective concentration of 10μM.

结果:我们在培养的小胶质细胞系发现,卡巴胆碱显著减少小胶质细胞的数量,并能有效抑制粒细胞巨噬细胞集落刺激因子诱导的小胶质细胞数量增多,并存在剂量依赖效应,10μ M浓度效果最为显著。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。