胶质母细胞瘤

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Results: 4 cases were geminoma, 3 cases were teratoma, 1 case was choriocarcinoma, 4 cases were glioma, 2 cases were meningiomas, pineoblstoma, neuroblastoma, dermoid cyst and arachnoid cyst each had one case. It maybe very difficult if we diagnosed only through MR signals. Due to the multitude origin of histology, we can diagnose through some special signals, such as adipose, cystic degeneration, hemorrhage and implant dissemination. We can also combined with clinical examination which is help to differential diagnosis.

结果：生殖细胞瘤4例，畸胎瘤3例，1例绒毛膜癌，胶质瘤4例，脑膜瘤2例，松果体母细胞瘤、神经母细胞瘤、皮样囊肿及蛛网膜囊肿各1例，仅通过MR信号较难诊断，由于肿瘤组织学来源多，可通过一些特殊信号如脂肪、囊变、出血、种植播散等，并结合临床检查来进行鉴别诊断。

Neuroectoderm; neural crest; neural plate; floor plate; neural tube; neuraxis; neurulation; neuroblasts; neural stem cells; neuroprogenitor cells; stem cells; differentiation; ontogeny; morphogenesis; histogenesis; organogenesis; synaptogenesis; gangliogenesis; embryogenesis; axonogenesis; retinogenesis; gliogenesis; glial progenitor cells; oligodendrocyte progenitor cells; retinal progenitor cells; nerve growth factor; neurotrophic factors; trophic factors; growth factors; neural tube defects; anencephaly; spina bifida; neuroblastoma cells; neurogenesis; development; developmental stages

神经外胚层；神经脊；神经板；底板；神经管；轴索；神经胚形成；成神经细胞；神经干细胞；神经母细胞；干细胞；分化；个体发生；形态发生；组织发生；器官发生；突触发生；gangliogenesis；胚胎发生；axonogenesis；retinogenesis；gliogenesis；神经胶质祖细胞；少突神经胶质细胞祖细胞；视网膜祖细胞；神经生长因子；神经营养因子；营养因子；生长因素；神经管故障；无脑；脊柱裂；成神经细胞瘤细胞；神经发生；发展；发展进程

Results The etiology of exophthalmos in children includes two aspects:（1）the outside of ocular diseases,mainly including Langerhans cell histiocytosis,chloroma,neuroblastoma etc.（2）ocu-lar diseases,mainly including retioblastoma,rhabdomyosarcoma of the orbit,glioma of optic nerve and angioma of the orbit and so on.

结果 提示小儿突眼病因主要包括两方面：（1）眼外疾患，主要包括有郎格罕组织细胞增生症、绿色瘤、神经母细胞瘤等；（2）眼部疾患，主要包括视网膜母细胞瘤、眶横纹肌肉瘤、视神经胶质瘤、眶内血管瘤等。

To explore the expression of neuron specific enolaes, S protein(S100) and glial fibrillary acidic protein in retinoblastoma and its clinical significance.

目的探讨神经元特异性烯醇化酶、酸性钙结合蛋白(S100)及胶质纤维酸性蛋白在视网膜母细胞瘤中的表达及临床意义。

I don't think this is clear cell meningioma, chordoma, central neurocytoma, hemangioblastoma, oligodendroglioma, ependymoma or DNET.

我不考虑透明细胞型脑膜瘤、脊索瘤、中枢神经细胞瘤、血管母细胞瘤、少突胶质细胞瘤、室管膜瘤或胚胎发育障碍的神经上皮肿瘤。

The level of β-tp was in direct proportional to the proliferation of cell in the oligodendroglioma cell lines (SHG-44, U-251, BT-325), but not in the non-oligodendroglioma cell lines (oophroma, prostate-carcinoma and neuro-oocyte).

但在非胶质瘤细胞株，如卵巢癌细胞，神经母细胞瘤细胞及前列腺癌细胞株等，β-tp的浓度与细胞增殖的趋势相反。

Some cell dropped into the cavity and became free. Thrombosis or part organization could be seen. The internal elastic layer became thin, disappear or broken. In internal and middle layer existed fibroblasts, fibrocytes and collagen. Some of the wall indicated hyaline change, soomth muscle cell decreased greatly. The massive inflammatory cells invaded the middle and external layer. There were many foam cells in the capsule tissue. Cytoplasm was filled with fatty tissue and cholesterol. some cavities were full of thrombosis. Some thrombosis was fibrosis, the bottom was organization. The surface of the thrombosis existed red blood cell and librae.(2)Elatic fibrila staining: the internal elastic menbrane almost completely disappeared, the intact internal elastic menbran could be seen in the new small vessels.

动脉瘤管壁厚薄明显不均，全层或局部区域显著变薄向外膨出，内皮细胞空泡变性或坏死脱落，部分内皮细胞剥离并突入管腔成游离状，可见血栓形成及部分血栓机化；内弹力板变薄、消失或突然中断；在内膜及中膜部位主要为纤维母细胞、纤维细胞和大片胶原；部分动脉瘤壁呈均质状玻璃样变，平滑肌细胞明显减少；中膜和外膜可见大量的炎性细胞浸润；瘤壁组织有纤维母细胞、纤维细胞、大片胶原成分及较多泡沫细胞，胞浆内充满脂类物质及胆固醇结晶；部分动脉瘤腔内充满血栓，有的血拴已经纤维化，血栓基部机化，血栓表面有红细胞和纤维素。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。