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胶质母细胞瘤

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Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mixed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mix ed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

Fig.3 The astrocytes in the area of gliosis around the anaplastic astrocytoma displayed Fas expression.

在多形性胶质母细胞瘤中内增生的血管内皮旦Fas强阳性,瘤细胞变为Fas阳性

Materials and Methods: Two cases of brain tumors (one was glioblastoma, the other was central neurocytoma) were performed dynamic enhanced CT and DSC-T2~* MR perfusion imaging before operations.

材料和方法:术前对2例脑肿瘤(1例胶质母细胞瘤,另1例中央神经细胞瘤作为对照)分别行动态对比增强CT灌注和动态T2~*敏感对比增强平面回波(DSC-T2~*)MR灌注成像,分析两种灌注方法的rCBV、CBF结果。

In contrast, 11/15 primary glioblastomas contained a significant CD133 subpopulation that displayed neurosphere-like, nonadherent growth and asymmetrical cell divisions yielding cells expressing markers characteristic for all three neural lineages.

相反,15个原代胶质母细胞瘤中有11个含有明显的CD133阳性亚群,呈神经球样,非附着性生长和非对称性细胞分裂,后者产生表达所有三种神经细胞系的特征标志物的细胞。15

This is a retrospective analysis of 194 patients with primary malignant brain tumor, who registered between January 1, 1970 and December 31, 1979 in cancer registration, Cancer Therapy Center, Veterans General Hospital, Taipei, Taiwan, R.O.C. There were 36 cases of glioblastoma multiforme, 86 cases of malignant astrocytoma (grade Ⅲ and a few grade Ⅱ), 22 of medulloblastoma, 12 of oligodendroglioma, 11 of ependymoma or ependymoblastoma and 27 cases of other types. There were 141 male cases with ages ranging from ito 81 years with a mean of 33.3±19.3 and median of 34 years.

自1970年1月至1979年12月台北荣民总医院癌病治疗中心癌病登记组共登记了194例原发恶性脑瘤其中多形神经胶母细胞瘤有36例,第二级及第三级星细胞瘤有86例,神经管胚细胞瘤有22例,间胶质母细胞瘤有12例,室管膜瘤或室管膜胚细胞瘤(ependy-moblastoma)有11例,其他有27例。

About 48%(90/194) were below 29 years of age. Ninety-nine of 194 cases had either radiotherapy alone or supplementary treatment with radiotherapy following surgery. We analyzed multiple prognostic factors. The factors of importance included postoperative radiotherapy; female in glioblastoma multiforme; the primary tumor dose above 5000 rads and/or whole brain irradiation in malignant astrocytoma and glioblastoma multiforme; the primary tumor dose above 4500 rads in ependymoma, medulloblastoma and oligodendroglioma; and spinal axis irradiation above 2000 rads in ependymoma and medulloblastoma that produced a better prognosis than in other groups.

男与女之比例为2.7比1,年龄分布自1至81岁,平均年龄33.3±19.3岁,中值年龄为34岁,29岁以下占48%(90/194),其中99例单独或手术后辅以放射腺治疗,分析同种脑瘤的预后因素,其中多形神经胶母细胞瘤有手术后放射线治疗或女性,多形神经胶母细胞瘤合并星细胞瘤原发肿瘤剂量5000雷得以上或曾全颅腔照射,神经管胚细胞瘤,间胶质母细胞瘤,及室管膜瘤原发肿瘤剂量4500雷得以上,室管膜瘤及神经管胚细胞瘤有脊轴照射2000雷得以上预后均佳,且统计上有显著的差异。

Methods:Thirty-seven glioma specimens were classified as astrocytoma(25 cases, including 7 fibrillary cases; 6 protoplasmic cases; 12 anaplasfic cases), and glioblastoma( 12 cases,including 4 GBM cases).

37例人脑胶质瘤标本按WHO分类标准(1990)分为:星形细胞瘤(25例,纤维型7例,原浆型6例,间变型12例),胶质母细胞瘤(12例,包括GBM4例)。

Results Tag was found in all of 8 ependymomas, 2 choroid plexus papillomas, 2 human glioma cell lines, 90% of pituitary adenomas (9/10), 73% of astrocytomas (11/15), 70% of meningiomas (7/10), 50% of glioblastomas multiforme (4/8), and 33% of medulloblastomas (2/6). None of the 8 normal brain tissues were positive for Tag, nor were 5 oligodendrogliomas and 1 pineocytoma.

结果 Tag在8例室管膜瘤、2例脉络丛乳头状瘤及2株人脑胶质瘤细胞系中全部表达;垂体腺瘤Tag阳性率为90%(9/10),星形胶质细胞瘤73%(11/15),脑膜瘤70%(7/10),多形性胶质母细胞瘤50%(4/8),髓母细胞瘤33%(2/6);5例少枝胶质细胞瘤、1例松果体瘤及8例正常人脑组织无Tag表达。

Oncolytic adenovirus H101 could replicate and cause oncolysis effects on glioblastoma U251 cells, it shows greater oncolysis effects and much more H101mRNA expression by enhanced virus tite or prolonged time.

1。溶瘤病毒制剂H101对体外培养的人类胶质母细胞瘤U251存在明显的抑制作用,能够在肿瘤细胞内复制,并最终起到溶瘤作用,并且胶质母细胞瘤U251细胞内病毒的产量随时间的延长而增大。2。

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