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Iron in the form of ferritin is highly toxic and may cause neural death and reactive gliosis. Astrocytes and microglia are responsible for uptake of excessive CSF iron in superficial siderosis.

星形胶质细胞和小胶质细胞可摄取脑脊液中过多的铁,而铁蛋白中铁的毒性又可导致神经元坏死和反应性神经胶质增生。

The growth speed of the cells with transfected Tob gene got slowly, even to a growth arrest.

结论Tob基因转染后的胶质瘤细胞生长受到明显抑制,出现向正常胶质细胞的分化和凋亡现象,提示Tob基因确实是一胶质瘤细胞增殖抑制基因,值得进一步做功能研究和实验性基因治疗研究。

Objective: To observe the quantitative and morphological changes of astrocytes in nucleus of solitary tract after vagus nerve stimulation.

目的:观察颈部迷走神经千刺激后孤束核内星形胶质细胞数量、形态的改变,同时在电镜水平观察星形胶质细胞与神经元之间突触形态、数量的变化,从胶质细胞的角度阐明VNS治疗神经精神疾病的重要机制。

Zymogen form (72kD) of MMP-2 was not significant difference among four grades of gioma.

与Ⅰ级胶质瘤相比,Ⅱ、Ⅲ、Ⅳ级胶质瘤组织MMP-2活性形式(62kD)明显升高(P.05),而在4个级别的胶质瘤之间,酶原形式MMP-2(72kD)无明显差别。

Astroglia had an apprant change of cell cycle in epileptogenesis, which may be an important mechanism involing gliosis and even development of glial scar.

星形胶质细胞细胞周期的改变是引起星形胶质细胞过度增殖,产生胶质疤痕和形成癫痫的重要机制之一。

Results 1、The CD11b-positive microglia were dyed low brown with small bacilliform cell bodies,ramified morphology,thin and long protuberance in CON and NIC group;In LPS group,the CD11b-positive microglia were dyed chocolate brown with more big roundish cell bodies,thicker and shorter processes;Most CD11b-positive microglia were dyed brown with bacilliform cell bodies,ramified morphology and few cells were dyed deep brown with more big roundish cell bodies,thicker and shorter protuberance in NIC+LPS group.

结果 1、CON组与NIC组CD11b阳性小胶质细胞胞体小,呈杆状,突起细长,染成浅棕色:LPS组小鼠脑内CD11b阳性小胶质细胞胞体增大,呈圆形,突起粗而短,染成棕褐色;NIC+LPS组少量CD11b阳性小胶质细胞胞体增大,圆形,突起变粗变短,染成深棕色,多数呈杆状,突起少、细长,染成浅棕色。

The antibodies to cathepsin D and glial fibrillary acid protein and immunohistochemical PAP technique were used to observe the changes in microglia and astrocytes in the cerebella from NPC and normal mice of different ages.

应用组织蛋白酶D和胶质原纤维酸性蛋白抗体以及免疫组织化学方法,观察生后不同年龄的NPC和正常小鼠小脑内小胶质细胞和星形胶质细胞的变化。

Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mixed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

Astrocytoma 45 cases, oligodendroglioma 21 cases, colloid female cytoma 25 cases, mix ed gliomas 9 cases.

其中星形细胞瘤45例,少突胶质细胞瘤21例,胶质母细胞瘤25例,混合型胶质瘤9例。

Week. Conclusions The S1 area brain glioma model established by this method in rats had the same characters as human brain glioma. The tumor growth period was short and the subsisting period was stable without extracerebral metastasis and extracranial extension. This model is suitable for laboratory and treatment study of brain gliomas.

该方法建立的S1区脑胶质瘤模型具备与人脑胶质瘤生长相似的特性,肿瘤形成时间短,生存期稳定,且无脑外转移和颅外扩散,适合各种脑胶质瘤实验治疗研究。

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