胶质

For further understanding the effect of the strain on K-bearing silicate mineral, an experiment with KO2 strain cultured in nitrogen-containing and nitrogen-free medium was conducted. By putting mineral powders into the medium and measuring the concentration of capsular polysaccharides, we concluded that the strain can accelerate the weathering rate of silicate minerals. The results showed that the polysaccharides secreted by the strain in the growth process could help the bacterial to adhere to the mineral surface effectively, and created the bacterium-mineral complex, which formed a mircro-enviorment avail the release of potassium. Another result was that there was higher level of Carbonic Anhydrase activity, which revealed that some exo-protein or enzyme produced by the bacterial had postive impact on the process of releasing potassium ion. We carried out the bacterial fermentation for larger scale production of the bacterial secretion, which was used to sperate, and identify the small molecules related to the mineral-bacterial interaction. After the analysis, it was found that the strain can produce many kinds of small molecules, such as 2-Hydroxybenzoic acid, 4-Hydroxyphenylacetic acid, methyl-4-hydroxybenzoate, etc.

分别将菌株接入含有不同矿粉的培养基中培养，检测其在有氮、无氮培养基中荚膜多糖含量的变化，并在以钾长石和黑云母为矿源的情况下，比较研究了菌株在有氮、无氮培养基中对矿物的风化能力，通过一系列的实验，证实胶质芽孢杆菌在生长过程中所分泌的粘稠胞外聚糖可帮助细菌有效黏附在矿物表面，形成细菌-矿物复合体，并改变及维持该复合体内部的微环境，有助于该菌的解钾作用，而且细菌分泌的胞外蛋白质在该菌对含钾硅酸盐矿物的解钾作用过程中发挥重要作用；将胶质芽孢杆菌接入以钾长石和黑云母为矿源的有氮、无氮培养基中培养，检测到该菌碳酸酐酶活性的变化，并进行批量发酵后小分子酸性分泌产物的提取、分离、纯化与鉴定等方面的研究，结果表明，该菌可产生2-羟基苯甲酸，4-羟基苯乙酸，4-羟基苯甲酸甲酯等小分子物质。

In the experimental study section, the rats were divided into four groups, including the normal control, the model, the Piracetam, the QPC, and copied to AD model. After the treatment, we observed the effects on the AD rats' ability of leaning and memorizing, detecting the TChE activity in whole blood and the expression levels of the related biochemical indicators of As includeing GFAP、NGF and BDNF of the AD rats' brain hippocampus, then compared the QPC with other groups to reveal the mechanism of action of the QPC treating AD to bright.

在动物实验部分，我们通过塑造AD动物模型，设立正常对照组、模型组、脑复康组和强脾益智胶囊组，观察强脾益智胶囊对AD模型大鼠空间学习记忆能力的影响，检测AD大鼠全血、海马匀浆液中乙酰胆碱酯酶活性和通过免疫组化的方法检测胶质纤维酸性蛋白、神经生长因子、和脑源性神经营养因子的表达情况来反映星形胶质细胞的增值情况，以期揭示强脾益智胶囊对AD的治疗作用机理。

Results:Three important MRI feat ures of brain stem gliomas were found:①enlargement of brain stem contour.Using different sequences and planes the precise tumor location could be obtained.Sagittal scan could well display the early stage of brain stem glioma,the tectal glioma and cervicomedullary junction glioma.

结果：MRI表现有以下3个特征：①肿瘤使脑干的外形增大，通过不同序列和断面显示肿瘤的精确部位，矢状面对于显示胶质瘤的早期改变、顶盖部位及延髓颈髓联合部位的胶质瘤具有独特作用。

Results Most OECs were bipolar or tripolar, and the purity was estimated to be over 88.7%. The non-OECs cells consists of astrocytes, neurons, oligodendrocytes and fibroblas.

结果 体外培养的新生小鼠嗅鞘细胞主要为双极或三极细胞，其纯度可以达到88.7%以上，污染细胞中有星形胶质细胞、神经元、少突胶质细胞和成纤维细胞。

Short of seeing relatively large areas (greater than one 100x microscopic field) of glial neoplasm without admixed dysplastic neurons, I usually would not call it a ganglioglioma.

缺乏相对大区域（大于100倍显微镜视野）不混合存在分化不良神经元成分的胶质瘤成分，我通常不诊断为节细胞胶质瘤。

Objective To investigate the expression and its biological significance of 14-3-3 proteins in human gliomas.

目的检测14-3-3蛋白在人脑胶质瘤中的表达情况，探讨其在胶质瘤发生发展中的生物学意义。

Objective To investigate the expression and its biological significance of 14-3-3 proteins in human gliomas.

目的 检测14-3-3蛋白在人脑胶质瘤中的表达情况，探讨其在胶质瘤发生发展中的生物学意义。

NF-κB is an important oncogenic protein and plays an important role in occurrence and development of gliomas.

NF-κB p65是脑胶质瘤相关的一种癌蛋白，在胶质瘤的发生中发挥重要调节作用。

Results In contrast with enzymatic dissociation, the method of mechanical dissociation, breaking up great neurospheres into small spheres with gradually reduced pipette, had advantages of raising cell viability and shortening cell doubling time (P.05). After NSCs being cultured long term in vitro, the number of neurons generated decreased with passaging, whereas the number of astrocytes increased.

体外长期培养条件下，随着培养时间的延长，NSCs分化为神经元的比例逐渐降低，星形胶质细胞的比例逐渐增高；在4~12代NSCs分化为神经元的能力表现出下降的趋势，但仍较为稳定；12代后，神经元的分化比例迅速下降，星形胶质细胞的比例迅速上升。

The molecular basis of chemoresistance is poorly understood, precluding adances in glioma treatment and leaing gliomas among the most lethal tumors.

药物抵抗的分子基础尚未被很好的阐明，排除了对治疗敏感的胶质瘤，而留下的胶质瘤便是最为致命性的。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。